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    Method of controlled drug delivery from implant device
    1.
    发明授权
    Method of controlled drug delivery from implant device 有权
    从植入装置控制药物递送的方法

    公开(公告)号：US07892221B2

    公开(公告)日：2011-02-22

    申请号：US11041161

    申请日：2005-01-21

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Achim Göpferich

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Achim Göpferich

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： Reservoir-based medical devices are provided. In one embodiment, the medical device comprises a substrate; at least two discrete, microfabricated reservoirs provided in spaced positions across at least one surface of the substrate; discrete reservoir caps covering the at least two reservoirs; and control circuitry for selectively disintegrating the reservoir caps to open the reservoirs. The reservoirs of the device can include a diagnostic reagent or other molecules useful in medical diagnostics. In one embodiment, the reservoir cap comprises an anode and the control circuitry comprises a cathode and a power source for creating an electric potential between the cathode and the anode. Application of the electric potential causes the reservoir cap to disintegrate, thereby opening the reservoir.

    摘要翻译： 提供了基于水库的医疗设备。 在一个实施例中，医疗装置包括基底; 至少两个离散的，微制造的储存器，跨过衬底的至少一个表面设置在间隔位置; 覆盖至少两个储存器的分立贮存器盖; 以及用于选择性地分解储存器盖以打开储存器的控制电路。 装置的储存器可以包括诊断试剂或用于医学诊断的其它分子。 在一个实施例中，储存器盖包括阳极，并且控制电路包括用于在阴极和阳极之间产生电位的阴极和电源。 施加电势会导致储存器盖分解，从而打开储存器。

    Medical device with controlled reservoir opening
    4.
    发明授权
    Medical device with controlled reservoir opening 有权
    具有受控储存器开口的医疗装置

    公开(公告)号：US07918842B2

    公开(公告)日：2011-04-05

    申请号：US10783897

    申请日：2004-02-20

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： Implantable medical devices are provided for controlled release of drugs. In one embodiment, the device comprises a support structure; two or more discrete reservoirs provided in spaced positions across at least one surface of the support structure; and a release system loaded in each of the reservoirs, the release system including drug molecules dispersed in a degradable matrix material, wherein release of the drug molecules from the reservoir is controlled by in vivo disintegration of the matrix material. In another embodiment, the device comprises a support structure; two or more discrete reservoirs provided in spaced positions across at least one surface of the support structure; and a release system loaded in each of the reservoirs, the release system including drug molecules dispersed in a non-degradable matrix material, wherein release of the drug molecules from the reservoir is controlled by in vivo diffusion of the drug molecules from the matrix material.

    摘要翻译： 提供可植入医疗器械用于药物的控制释放。 在一个实施例中，该装置包括支撑结构; 两个或多个离散的储存器设置在跨过支撑结构的至少一个表面的间隔位置; 以及装载在每个储存器中的释放系统，所述释放系统包括分散在可降解基质材料中的药物分子，其中药物分子从储存器的释放通过基质材料的体内分解来控制。 在另一个实施例中，该装置包括支撑结构; 两个或多个离散的储存器设置在跨过支撑结构的至少一个表面的间隔位置; 以及装载在每个储存器中的释放系统，所述释放系统包括分散在不可降解基质材料中的药物分子，其中通过药物分子从基质材料的体内扩散来控制药物分子从储存器的释放。

    Microchip reservoir devices using wireless transmission of power and data
    5.
    发明授权
    Microchip reservoir devices using wireless transmission of power and data 有权
    Microchip库设备使用无线传输电源和数据

    公开(公告)号：US07226442B2

    公开(公告)日：2007-06-05

    申请号：US09975672

    申请日：2001-10-10

    申请人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    发明人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    IPC分类号： A61K9/22

    CPC分类号： A61B1/041 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0051 ,  A61K9/0097 ,  A61M5/14 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2210/0612 ,  A61M2210/1042 ,  G06F19/00

    摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

    摘要翻译： 提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。 在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。 在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

    Medical device with array of electrode-containing reservoirs
    6.
    发明授权
    Medical device with array of electrode-containing reservoirs 有权
    带有电极储存器阵列的医疗器械

    公开(公告)号：US07070592B2

    公开(公告)日：2006-07-04

    申请号：US10886405

    申请日：2004-07-07

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22 ,  A61N1/30

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  Y10T436/25

    摘要： Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.

    摘要翻译： 提供用于医疗诊断的装置，包括基底; 一系列水库; 一个或多个电极至少部分地位于储存器内部; 多个分立储存器盖，覆盖多个储存器中的开口; 用于选择性地将储存器盖分解或渗透在储存器开口上的控制电路; 和任选地，在储存器中的诊断试剂。 还提供了用于受控输送包含基底的分子的装置; 一系列水库; 储存器中的释放系统包括用于释放的分子; 一个或多个电极附着到储存器内的基底或储存器外部的表面，其中电极不是储​​存器盖; 以及用于施加跨过电极的电流或电位的装置，有效地激活分子从储存器的释放。 该装置可适于植入用于体内诊断或药物递送。