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公开(公告)号:US20050131050A1
公开(公告)日:2005-06-16
申请号:US11048037
申请日:2005-01-31
申请人: John Talley , Thomas Penning , Paul Collins , Donald Rogier , James Malecha , Julie Miyashiro , Stephen Bertenshaw , Ish Khanna , Matthew Graneto , Roland Rogers , Jeffery Carter , Stephen Docter , Stella Yu
发明人: John Talley , Thomas Penning , Paul Collins , Donald Rogier , James Malecha , Julie Miyashiro , Stephen Bertenshaw , Ish Khanna , Matthew Graneto , Roland Rogers , Jeffery Carter , Stephen Docter , Stella Yu
IPC分类号: C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/416 , A61K31/4152 , C07D231/10 , C07D45/02
CPC分类号: C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycaronyl, cyano, cyanoalkyl, carboxyl, aminocaronyl, alkylaminocarbonyl, cycloalklaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, amioncarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not arakenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.
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公开(公告)号:US5308140A
公开(公告)日:1994-05-03
申请号:US25878
申请日:1993-03-03
申请人: Stella Yu
发明人: Stella Yu
摘要: A shock-absorbing device includes a saddle support which is to be mounted to a bottom side of a saddle of a bicycle seat. The saddle support is made of metal and has a substantially U-shaped horizontal portion with left and right arms. Each of the left and right arms has a distal upwardly curving end. The saddle support further has a pair of extensions which extend respectively from the upwardly curving end of the left and right arms. The extensions are disposed above and are parallel to a respective one of the left and right arms. Each of the extensions has a distal outwardly bent hook end. The shock-absorbing device further includes an adjustment unit with a pair of cylindrical portions, which are clamped tightly between a respective one of the left and right arms and a respective one of the extensions, and a retaining unit which extends across the left and right arms so as to retain the adjustment unit on the saddle support.
摘要翻译: 减震装置包括将安装到自行车座椅的鞍座的底侧的鞍座支撑件。 鞍座支撑件由金属制成,并且具有大致U形的水平部分,其具有左右臂。 左右臂中的每一个具有远端向上弯曲的端部。 鞍座支撑件还具有分别从左右臂的向上弯曲端延伸的一对延伸部。 延伸部设置在左右臂的相应一个上方并且平行。 每个延伸部具有远端向外弯曲的钩端。 所述减震装置还包括具有一对圆柱形部分的调节单元,所述一对圆柱形部分紧密地夹紧在所述左臂和右臂中的相应一个和所述延伸部中的相应一个之间,以及保持单元,其横跨左右延伸 以便将调节单元保持在鞍座支撑件上。
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公开(公告)号:US09336023B2
公开(公告)日:2016-05-10
申请号:US12642129
申请日:2009-12-18
申请人: Himagiri Mukkamala , Cliff Collins , Stella Yu
发明人: Himagiri Mukkamala , Cliff Collins , Stella Yu
CPC分类号: G06F9/44542 , G06F8/20 , G06F8/30 , G06F8/35 , G06F8/76 , G06F9/445 , G06F9/44536
摘要: Systems, methods and computer program products for mobile device application design are described herein. The method accesses a data model corresponding to a selected mobile platform. The data model is used by a device application designer to generate, model, and debug a mobile application. The data model is used to take into consideration characteristics of the selected platform and a selected mobile device as the application is designed. The application is structured and generated for a selected platform that is independent of the data model, but is cognizant of the selected platform. A simulator models the application user interface (UI) as it will appear on the selected platform. The method performs platform-specific validation and allows for correction of various aspects of a generated application including platform-specific features. The tool generates a graphical image that can guide a developer to either generated code or help files corresponding to framework libraries.
摘要翻译: 本文描述了用于移动设备应用设计的系统,方法和计算机程序产品。 该方法访问与选定的移动平台相对应的数据模型。 数据模型由设备应用程序设计者用于生成,建模和调试移动应用程序。 在设计应用程序时,数据模型用于考虑所选平台的特性和选定的移动设备。 该应用程序是针对独立于数据模型的选定平台进行构造和生成的,但对所选平台的认知。 模拟器将在所选平台上显示应用程序用户界面(UI)。 该方法执行平台特定的验证,并允许修正生成的应用程序的各个方面,包括平台特定的功能。 该工具生成图形图像,可以指导开发人员生成与框架库相对应的代码或帮助文件。
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公开(公告)号:US20110154287A1
公开(公告)日:2011-06-23
申请号:US12642129
申请日:2009-12-18
申请人: Himagiri MUKKAMALA , Cliff Collins , Stella Yu
发明人: Himagiri MUKKAMALA , Cliff Collins , Stella Yu
IPC分类号: G06F9/44
CPC分类号: G06F9/44542 , G06F8/20 , G06F8/30 , G06F8/35 , G06F8/76 , G06F9/445 , G06F9/44536
摘要: Systems, methods and computer program products for mobile device application design are described herein. The method accesses a data model corresponding to a selected mobile platform. The data model is used by a device application designer to generate, model, and debug a mobile application. The data model is used to take into consideration characteristics of the selected platform and a selected mobile device as the application is designed. The application is structured and generated for a selected platform that is independent of the data model, but is cognizant of the selected platform. A simulator models the application user interface (UI) as it will appear on the selected platform. The method performs platform-specific validation and allows for correction of various aspects of a generated application including platform-specific features. The tool generates a graphical image that can guide a developer to either generated code or help files corresponding to framework libraries.
摘要翻译: 本文描述了用于移动设备应用设计的系统,方法和计算机程序产品。 该方法访问与选定的移动平台相对应的数据模型。 数据模型由设备应用程序设计者用于生成,建模和调试移动应用程序。 在设计应用程序时,数据模型用于考虑所选平台的特性和选定的移动设备。 该应用程序是针对独立于数据模型的选定平台进行构造和生成的,但对所选平台的认知。 模拟器将在所选平台上显示应用程序用户界面(UI)。 该方法执行平台特定的验证,并允许修正生成的应用程序的各个方面,包括平台特定的功能。 该工具生成图形图像,可以指导开发人员生成与框架库相对应的代码或帮助文件。
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