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公开(公告)号：US5480449A
公开(公告)日：1996-01-02
申请号：US10133
申请日：1993-01-28
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/36 , A61L27/44 , B29C35/02 , B29C70/86 , A61F2/02 , B23Q9/02
CPC分类号： B29C70/86 , A61F2/30907 , A61F2/30965 , A61L27/443 , B29C35/0272 , A61F2/3094 , A61F2/3662 , A61F2002/30004 , A61F2002/30009 , A61F2002/30014 , A61F2002/30065 , A61F2002/30357 , A61F2002/3038 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2002/3652 , A61F2210/0071 , A61F2220/0033 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2310/00023 , A61F2310/00029 , B29C2035/0211 , B29L2031/7532 , Y10S623/911 , Y10T29/49897
摘要： A process for making a composite stem for a prosthesis by providing a tapered metal core with a predetermined cross section and a composite shell having a tapered cavity having a cross sectional configuration to receive the metal core. Adhesive is applied to the metal core and the core is placed in the cavity and pressure is applied along the axis of the metal core toward the smaller end of the core to force the core against the composite shell and heat is applied with the pressure to bond the composite shell to the metal core.
摘要翻译： 一种用于通过提供具有预定横截面的锥形金属芯制造用于假体的复合杆的方法，以及具有锥形腔体的复合壳体，所述锥形腔体具有用于容纳金属芯的横截面构造。 将粘合剂施加到金属芯上，并且将芯放置在空腔中，并且沿着金属芯的轴线朝向芯的较小端施加压力，以迫使芯抵靠复合壳，并施加压力以粘合 复合外壳到金属芯。
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公开(公告)号：US5314492A
公开(公告)日：1994-05-24
申请号：US881105
申请日：1992-05-11
CPC分类号： B29C70/86 , A61F2/30907 , A61F2/30965 , A61L27/443 , B29C35/0272 , A61F2/3094 , A61F2/3662 , A61F2002/30004 , A61F2002/30009 , A61F2002/30014 , A61F2002/30065 , A61F2002/30357 , A61F2002/3038 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2002/3652 , A61F2210/0071 , A61F2220/0033 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2310/00023 , A61F2310/00029 , B29C2035/0211 , B29L2031/7532 , Y10S623/911 , Y10T29/49897
摘要： A composite stem for a prosthesis, particularly a hip prosthesis, including a metal core and a fiber reinforced composite shell surrounding the core to provide modulus values that are similar to bone. The composite shell is preferably composed of braided fibers and a thermoplastic resin. The stiffness of the prosthesis can be varied along the length of the stem. The metal core contributing between 5 and 25 percent of the total flexural stiffness of the stem.
摘要翻译： 用于假体，特别是髋关节假体的复合杆，包括金属芯和围绕芯的纤维增强复合壳，以提供类似于骨的模数值。 复合外壳优选由编织纤维和热塑性树脂组成。 假体的刚度可以沿茎的长度变化。 金属芯占杆的总弯曲刚度的5％至25％。
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3.发明授权Implantable articles with as-cast macrotextured surface regions and method of manufacturing the same 失效具有铸态宏观结构表面区域的可植入制品及其制造方法
公开(公告)号：US5897592A
公开(公告)日：1999-04-27
申请号：US841199
申请日：1997-04-29
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/34 , A61F2/36 , A61F2/38 , B22C7/02 , B22C9/04 , B29C33/38 , B29C67/00
CPC分类号： B29C67/0081 , A61F2/30771 , B22C7/02 , B22C9/04 , A61F2/28 , A61F2/34 , A61F2/367 , A61F2/3676 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30322 , A61F2002/30682 , A61F2002/30952 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2250/0023 , A61F2250/0026 , A61F2310/00023 , A61F2310/00029 , B29C33/3842 , B29L2031/7532 , Y10S623/901 , Y10S623/923
摘要： An implantable article having on at least a portion of its exterior surface an integral, as-cast macrotextured surface with macropores having undercut edge profiles. A complex macrotextured surface is provided by forming a casting mold so that the mold has complementary macrotextured surface features formed by three-dimensional printing techniques, and casting a molten metal within or in contact with the casting mold to form the implantable article. In a hybrid process, one or more printed surface mold plates are attached by hand, or in a wax molding process, to a simpler wax preform, and an investment is made in which the plates are incorporated into the investment mold. A casting is then made, with each preform yielding one cast article, and the incorporated plate forming the desired surface macrotexture on a region of the cast article. Pore size, porosity and pore shape may be varied across the surface, or varied with depth, to independently enhance different mechanical and physiological factors at the bone-prosthesis interface.
摘要翻译： 一种可植入制品，其外表面的至少一部分具有整体的铸态宏观结构表面，大孔具有底切边缘轮廓。 通过形成铸模来提供复杂的宏观结构表面，使得模具具有由三维印刷技术形成的互补的宏观结构表面特征，以及在熔模内铸造或与铸模接触以形成可植入制品。 在混合过程中，一个或多个印刷的表面模板用手或蜡模制工艺连接到更简单的蜡预成型件上，并且投入了将板结合到投资模具中。 然后制造铸件，其中每个预成型件产生一个铸造制品，并且所合并的板在铸造制品的区域上形成所需的表面宏观纹理。 孔尺寸，孔隙度和孔隙形状可以在整个表面上变化，或随深度而变化，以独立地增强在骨假体界面处的不同的机械和生理因素。
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4.发明授权Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same 失效具有直接铸造宏观表面区域的骨假体及其制造方法
公开(公告)号：US5665118A
公开(公告)日：1997-09-09
申请号：US198607
申请日：1994-02-18
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/34 , A61F2/36 , A61F2/38 , B22C7/02 , B22C9/04 , B22D25/02 , B29C33/38 , B29C67/00
CPC分类号： B29C67/0066 , A61F2/30771 , A61F2/30942 , B22C7/02 , A61F2/28 , A61F2/367 , A61F2/3859 , A61F2/389 , A61F2002/30322 , A61F2002/30682 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/3401 , A61F2250/0026 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , B29C33/3842 , B29L2031/7532
摘要： An implantable article having on at least a portion of its exterior surface an integral, as-cast macrotextured surface having pores with undercut edge profiles is provided. The integral, as-cast macrotextured surface is able to be formed on the implantable articles by a modified casting process. As part of a casting process, positive models of the articles to be cast, or parts thereof, are formed by stereolithographic techniques. Cavities or molds, representing negative images of the articles to be cast, are then formed by encasing one or more models in a refractory material. The positive models are then extracted by heating and thus melting the material from which they are made. Thereafter, molten casting material can be poured into the resulting mold to obtain the implantable articles.
摘要翻译： 提供在其外表面的至少一部分上具有整体的铸态宏观结构表面的可植入制品，所述表面具有具有底切边缘轮廓的孔。 通过改进的铸造工艺能够在可植入物品上形成整体的铸态宏观结构表面。 作为铸造工艺的一部分，通过立体光刻技术形成要铸造的制品的正模型或其部分。 然后通过将一个或多个模型包裹在耐火材料中来形成代表待铸造制品的负像的腔或模具。 然后通过加热提取阳性模型，从而熔化它们制备的材料。 此后，将熔融铸造材料倒入所得模具中以获得可植入制品。
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公开(公告)号：US5716414A
公开(公告)日：1998-02-10
申请号：US798492
申请日：1997-02-10
申请人： Salvatore Caldarise
发明人： Salvatore Caldarise
CPC分类号： A61F2/3609 , A61F2/30965 , A61F2/34 , A61F2/30907 , A61F2/3094 , A61F2/32 , A61F2/3662 , A61F2/367 , A61F2/38 , A61F2002/30004 , A61F2002/30289 , A61F2002/30301 , A61F2002/30322 , A61F2002/30332 , A61F2002/30387 , A61F2002/30602 , A61F2002/30626 , A61F2002/3063 , A61F2002/30934 , A61F2002/30952 , A61F2002/30957 , A61F2002/30973 , A61F2002/3429 , A61F2002/3611 , A61F2002/3613 , A61F2002/3625 , A61F2002/365 , A61F2002/5039 , A61F2002/5041 , A61F2220/0025 , A61F2220/0033 , A61F2230/0091 , A61F2230/0095 , A61F2250/0014 , A61F2250/0026 , A61F2310/00029 , A61F2310/00179 , B29L2031/7532 , Y10T29/49988
摘要： An implantable bone prosthesis includes portions of two different materials which interfit with each other to form a unitary article having hard wear surface portions and strong, stiff portions for structural support. These portions are preferably formed of ceramic and of metal, respectively. The prosthesis is formed by making a multiply connected ceramic wear surface element having openings or passages therethrough, and casting the remainder of the prosthesis extending in the openings to form a mating or dendritic support or a frame interdigitated and interlocked with the ceramic wear surface. The frame may be shaped so that it contracts along a direction of shrinkage, as the casting cools, without binding against the ceramic body. In a spherical shell, such as used for the weight-bearing acetabular shell or ball joint of a hip, this is achieved with short, radially-directed interlock elements. Other connections of the two materials may include tapered bores, dovetail channels, fern-like dendritic structures, or the like. Ball and socket, trunion and other articulations are fabricated with high strength and durable wear properties.
摘要翻译： 可植入骨假体包括彼此相互配合的两种不同材料的部分，以形成具有硬磨损表面部分和用于结构支撑的坚固且坚硬的部分的整体制品。 这些部分优选分别由陶瓷和金属形成。 通过制造具有穿过其中的开口或通道的多重连接的陶瓷磨损表面元件并且将在假体中延伸的开口的其余部分铸造以形成配合或树枝状支撑件或与陶瓷磨损表面互锁并与之互锁的框架来形成假体。 框架可以被成形为使得当铸件冷却时，其沿收缩方向收缩，而不与陶瓷体结合。 在球形外壳中，例如用于髋臼的承重髋臼壳或球窝接头，这是通过短的径向定向互锁元件实现的。 两种材料的其它连接可以包括锥形孔，燕尾形通道，蕨样树突状结构等。 球轴承，钢丝绳和其他铰接件制造具有高强度和耐用的磨损性能。
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6.发明授权Implantable articles with as-cast macrotextured surface regions and method of manufacturing the same 失效具有铸态宏观结构表面区域的可植入制品及其制造方法
公开(公告)号：US5687788A
公开(公告)日：1997-11-18
申请号：US457227
申请日：1995-06-01
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/34 , A61F2/36 , A61F2/38 , B22C7/02 , B22C9/04 , B29C33/38 , B29C67/00 , B27C9/00
CPC分类号： B29C67/0081 , A61F2/30771 , B22C7/02 , B22C9/04 , A61F2/28 , A61F2/34 , A61F2/367 , A61F2/3676 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30322 , A61F2002/30682 , A61F2002/30952 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2250/0023 , A61F2250/0026 , A61F2310/00023 , A61F2310/00029 , B29C33/3842 , B29L2031/7532 , Y10S623/901 , Y10S623/923
摘要： An implantable article having on at least a portion of its exterior surface an integral, as-cast macrotextured surface with macropores having undercut edge profiles. A complex macrotextured surface is provided by forming a casting mold so that the mold has complementary macrotextured surface features formed by three-dimensional printing techniques, and casting a molten metal within or in contact with the casting mold to form the implantable article. In a hybrid process, one or more printed surface mold plates are attached by hand, or in a wax molding process, to a simpler wax preform, and an investment is made in which the plates are incorporated into the investment mold. A casting is then made, with each preform yielding one cast article, and the incorporated plate forming the desired surface macrotexture on a region of the east article. Pore size, porosity and pore shape may be varied across the surface, or varied with depth, to independently enhance different mechanical and physiological factors at the bone-prosthesis interface.
摘要翻译： 一种可植入制品，其外表面的至少一部分具有整体的铸态宏观结构表面，大孔具有底切边缘轮廓。 通过形成铸模来提供复杂的宏观结构表面，使得模具具有由三维印刷技术形成的互补的宏观结构表面特征，以及在熔模内铸造或与铸模接触以形成可植入制品。 在混合过程中，一个或多个印刷的表面模板用手或蜡模制工艺连接到更简单的蜡预成型件上，并且投入了将板结合到投资模具中。 然后制造铸件，其中每个预成型件产生一个铸造制品，并且所形成的板在东部制品的区域上形成所需的表面宏观纹理。 孔尺寸，孔隙度和孔隙形状可以在整个表面上变化，或随深度而变化，以独立地增强在骨假体界面处的不同的机械和生理因素。
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7.发明授权
公开(公告)号：US6008431A
公开(公告)日：1999-12-28
申请号：US713103
申请日：1996-09-16
CPC分类号： A61F2/30771 , A61F2/30767 , A61F2/3094 , A61F2/367 , A61F2/3672 , A61F2/3676 , A61F2002/30135 , A61F2002/30136 , A61F2002/30168 , A61F2002/30177 , A61F2002/30322 , A61F2002/3082 , A61F2002/30823 , A61F2002/30957 , A61F2002/365 , A61F2230/0004 , A61F2230/0043 , A61F2230/0056 , A61F2250/0026 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , B29C67/0051
摘要： A bone prosthesis has a growth enhancement coating recessed in and protected by its surface topography. The topographic features define gaps under a few millimeters which are readily spanned by new bone growth, while the features protect the coating from abrasion or physical damage. The topographic features substantially surround the coated regions, and prevent migration of flakes spalled during implantation or microparticles shed by the coating as it is resorbed or incorporated in new bone over time. In a preferred embodiment, edge features cast in the surface of a metal prosthesis include dovetail, undercut or skewed faces which firmly interlock with newly-growing bone to form a strong and shear-free, substantially rigid attachment. The prosthesis may be cast in a mold having a complex surface interlock texture, and these molds may be mass produced by an iterative three-dimensional printing technique to build each mold up in layers in the form of a suitable casting negative. The prosthesis is then cast of molten metal in the mold, and the mold material is broken away and cleaned off, e.g., by an etch. A growth enhancer such as hydroxyapatite (HA) is plasma-sprayed to selectively deposit on and completely cover the floors of the recesses formed in the casting. Preferably, the upper surfaces about the recesses are polished, and the recess walls are overhung so they are masked from the coating process, causing the HA coating to adhere only in the protected floor regions. The HA floors are at the bottom of pits or macropores, at a depth of under three millimeters, and preferably one-half to two millimeters, so that new bone growth spans the gaps and penetrates into the prosthesis over an extended surface textured region.
摘要翻译： 骨假体具有凹陷并由其表面形貌保护的生长增强涂层。 地形特征定义了几毫米以下的间隙，这些间隙容易被新的骨骼生长所跨越，而特征保护了涂层免受磨损或物理伤害。 地形特征基本上围绕涂覆区域，并且防止在植入期间剥落的片状物的迁移或被涂层脱落的微粒随着时间被吸收或并入新骨中。 在优选实施例中，铸造在金属假体的表面中的边缘特征包括燕尾，底切或倾斜的表面，其牢固地与新生长的骨骼互锁以形成坚固且无剪切的基本上刚性的附件。 假体可以铸造在具有复杂表面互锁纹理的模具中，并且这些模具可以通过迭代的三维印刷技术大量生产，以适当的铸造底片的形式将层压成型。 然后将假体浇铸在模具中的熔融金属，并且例如通过蚀刻将模具材料分离并清除。 等离子体喷涂生长增强剂如羟基磷灰石（HA）以选择性地沉积并完全覆盖铸件中形成的凹陷的地板。 优选地，围绕凹部的上表面被抛光，并且凹陷壁被悬垂，使得它们被涂覆过程掩蔽，使得HA涂层仅粘附在受保护的地板区域中。 HA底部位于凹坑或大孔的底部，深度在三毫米以下，优选为一半至二毫米，使得新的骨生长跨越间隙并在延伸的表面纹理区域上穿透到假体中。
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8.发明授权Implantable articles with as-cast macrotextured surface regions and method of manufacturing same 失效具有铸态宏观结构表面区域的可植入制品及其制造方法
公开(公告)号：US5658334A
公开(公告)日：1997-08-19
申请号：US662170
申请日：1996-07-24
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/34 , A61F2/36 , A61F2/38 , B22C7/02 , B22C9/04 , B29C33/38 , B29C67/00
CPC分类号： B29C67/0081 , A61F2/30771 , B22C7/02 , B22C9/04 , A61F2/28 , A61F2/34 , A61F2/367 , A61F2/3676 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30322 , A61F2002/30682 , A61F2002/30952 , A61F2002/30957 , A61F2002/30958 , A61F2002/30968 , A61F2250/0023 , A61F2250/0026 , A61F2310/00023 , A61F2310/00029 , B29C33/3842 , B29L2031/7532 , Y10S623/901 , Y10S623/923
摘要： An implantable article having on at least a portion of its exterior surface an integral, as-cast macrotextured surface with macropores having undercut edge profiles. A complex macrotextured surface is provided by forming a casting mold so that the mold has complementary macrotextured surface features formed by three-dimensional printing techniques, and casting a molten metal within or in contact with the casting mold to form the implantable article. In a hybrid process, one or more printed surface mold plates are attached by hand, or in a wax molding process, to a simpler wax preform, and an investment is made in which the plates are incorporated into the investment mold. A casting is then made, with each preform yielding one cast article, and the incorporated plate forming the desired surface macrotexture on a region of the cast article. Pore size, porosity and pore shape may be varied across the surface, or varied with depth, to independently enhance different mechanical and physiological factors at the bone-prosthesis interface.
摘要翻译： 一种可植入制品，其外表面的至少一部分具有整体的铸态宏观结构表面，大孔具有底切边缘轮廓。 通过形成铸模来提供复杂的宏观结构表面，使得模具具有由三维印刷技术形成的互补的宏观结构表面特征，以及在熔模内铸造或与铸模接触以形成可植入制品。 在混合过程中，一个或多个印刷的表面模板用手或蜡模制工艺连接到更简单的蜡预成型件上，并且投入了将板结合到投资模具中。 然后制造铸件，其中每个预成型件产生一个铸造制品，并且所合并的板在铸造制品的区域上形成所需的表面宏观纹理。 孔尺寸，孔隙度和孔隙形状可以在整个表面上变化，或随深度而变化，以独立地增强在骨假体界面处的不同的机械和生理因素。
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公开(公告)号：US5549697A
公开(公告)日：1996-08-27
申请号：US310727
申请日：1994-09-22
申请人： Salvatore Caldarise
发明人： Salvatore Caldarise
CPC分类号： A61F2/34 , A61F2/30771 , A61B17/86 , A61F2/3094 , A61F2/32 , A61F2/3662 , A61F2002/30014 , A61F2002/30324 , A61F2002/30563 , A61F2002/30571 , A61F2002/30685 , A61F2002/30795 , A61F2002/30803 , A61F2002/30957 , A61F2002/30973 , A61F2002/3401 , A61F2002/3438 , A61F2002/3472 , A61F2002/3611 , A61F2002/3625 , A61F2250/0018 , A61F2250/0036 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00203 , A61F2310/00215 , A61F2310/00239 , A61F2310/00281 , A61F2310/00317 , Y10S623/901
摘要： An implantable bone prosthesis, such as an acetabular shell, includes a bone engaging region that is made from a cast metal or metal alloy and an articulation surface that is formed of a ceramic material or a metal that is permanently attached to the metal bone engaging region. The bone engaging region of the prosthesis preferably includes a dampening mechanism to absorb some of the loading forces communicated to the acetabular cavity. The bone prosthesis is formed by a casting process from casting molds that are prepared using a three dimensional printing technique.
摘要翻译： 可植入骨假体（例如髋臼壳）包括由铸造金属或金属合金制成的骨接合区域和由陶瓷材料形成的关节表面或永久地附接到金属骨接合区域的金属 。 假体的骨接合区域优选地包括阻尼机构，以吸收与髋臼腔连通的一些负荷力。 骨假体通过使用三维印刷技术制备的铸模的铸造工艺形成。
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公开(公告)号：US5201767A
公开(公告)日：1993-04-13
申请号：US729674
申请日：1991-07-15
CPC分类号： A61F2/30767 , A61F2/367 , A61F2/34 , A61F2002/30879 , A61F2002/3668
摘要： An osteal prosthetic component of a prosthetic joint and a method of implanting an osteal prosthetic component in the medullary canal of a bone are disclosed. The osteal prosthetic component includes a stem for disposition within a medullary canal of a bone and a fluted wedge portion extending from the stem. The fluted wedge has wedge portions which define at least one flute between the wedge portions. An interference fit is formed between the wedge portions and the bone during implantation of the stem into the medullary canal. Movement of the osteal prosthetic component relative to the bone is thereby sufficiently limited to allow tissue growth into a tissue-ingrowth portion at the surface of the stem to substantially prevent micromotion of the stem relative to the bone.
摘要翻译： 公开了一种假体关节的骨修复部件和将骨修复部件植入骨髓腔中的方法。 骨修复组件包括用于置于骨的髓管内的茎和从茎延伸的带槽的楔形部分。 带槽的楔具有楔形部分，其在楔形部分之间限定至少一个凹槽。 在将柄植入髓质管内时，在楔部和骨之间形成过盈配合。 因此骨骼修复部件相对于骨骼的运动被充分地限制，以允许组织生长进入杆的表面的组织向内生长部分，以基本上防止茎相对于骨骼的微动。
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