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    Spinal fluid introduction
    1.
    发明授权
    Spinal fluid introduction 失效
    脊柱液介绍

    公开(公告)号：US07662133B2

    公开(公告)日：2010-02-16

    申请号：US10782900

    申请日：2004-02-23

    申请人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke ,  Peter A. Weissman

    发明人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke ,  Peter A. Weissman

    IPC分类号： A61M37/00 ,  A61B5/103 ,  A61B5/117

    CPC分类号： A61M5/1456 ,  A61B17/3401 ,  A61B17/8822 ,  A61M5/16827 ,  A61M5/16854 ,  A61M2025/0007 ,  A61M2205/3331

    摘要： A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.

    摘要翻译： 流体引入系统包括导引器，其构造成在脊柱内产生至少69kPa的压力，以及操作器，其配置成致动导引器以根据预定流体导入曲线将流体引入脊柱。 该系统可以包括具有用于接收指示流体引入参数的流体引入数据的代码的计算机可读介质，以及用于在与流体引入数据的时间相关的时间接收表示患者的响应的响应数据。 用于引入流体的方法包括将第一导引器定位在脊柱的第一部分中，将第二导引器定位在脊柱的第二不同部分中，并且不移除第一和第二导引器，将流体引入脊柱的第一部分 与第一导引器一起引入流体到第二引导器到脊柱的第二部分。

    Low temperature pressure stabilization of implant component
    2.
    发明授权
    Low temperature pressure stabilization of implant component 有权
    植入物组件的低温压力稳定

    公开(公告)号：US06184265B2

    公开(公告)日：2001-02-06

    申请号：US09362965

    申请日：1999-07-29

    申请人： John V. Hamilton ,  Mary Beth Schmidt ,  Keith Greer

    发明人： John V. Hamilton ,  Mary Beth Schmidt ,  Keith Greer

    IPC分类号： C08F246

    CPC分类号： A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  A61L27/16 ,  C08L23/06 ,  C08L2207/068 ,  C08L2312/06 ,  Y10S422/903 ,  Y10S522/911 ,  Y10S522/912

    摘要： Wear resistance and oxidation resistance of polymer material or a polymer component for bioimplantation are improved by packaging a polymer object in a sealed gas impermeable package substantially free of oxygen, irradiating the package with penetrating radiation to an extent sufficient to effect a desired substantial level of cross-linking within the polymer, and warming the packaged object while maintaining an elevated hydrostatic pressure to cause gases released during irradiation to recombine, stabilizing the material against subsequent oxidative change. The pressure stabilization terminates active sites, substantially eliminating free radicals. When applied to finished parts, the process simultaneously hardens and sterilizes the parts without degrading mechanical properties or dimensions. When applied to bulk material or unfinished parts, the part may be subsequent machined or otherwise finished, and sterilized by any conventional means. The procedure achieves high levels of cross linking without increasing susceptibility to aging or chemical degradation.

    摘要翻译： 聚合物材料或用于生物植入的聚合物组分的耐磨性和抗氧化性通过将聚合物物体包装在基本上不含氧的密封气体不可渗透的包装中，通过将穿透辐射照射到足以实现期望的相当程度的交叉 在聚合物内连接并加热包装物体，同时保持升高的静水压力以引起在照射期间释放的气体重组，使材料稳定化以防止随后的氧化变化。 压力稳定终止活性位点，基本上消除自由基。 当应用于成品时，该工艺同时硬化和消毒零件，而不会降低机械性能或尺寸。 当应用于散装材料或未完成的部件时，可以随后机械加工或以其他方式完成该部件，并且通过任何常规方法进行灭菌。 该程序实现高水平的交联，而不增加对老化或化学降解的易感性。

    Method for improving wear resistance of polymeric bioimplantable components
    10.
    发明授权
    Method for improving wear resistance of polymeric bioimplantable components 失效
    提高聚合物生物可植入组分耐磨性的方法

    公开(公告)号：US5577368A

    公开(公告)日：1996-11-26

    申请号：US415733

    申请日：1995-04-03

    申请人： John V. Hamilton ,  Mark A. Manasas ,  Timothy M. Flynn

    发明人： John V. Hamilton ,  Mark A. Manasas ,  Timothy M. Flynn

    IPC分类号： A61L27/00 ,  A61F2/30 ,  A61L2/08 ,  A61L27/16 ,  B65B31/04 ,  B65B55/08 ,  B65B55/16 ,  B65B31/02

    CPC分类号： A61L2/081 ,  A61L2/08 ,  A61L2/082 ,  A61L2/087 ,  A61L27/16 ,  B65B55/08 ,  B65B55/16 ,  A61L2202/24 ,  B65B31/04

    摘要： Wear resistance and oxidation resistance of bioimplantable polymeric parts is improved by packaging the parts within flexible, gas impermeable containers while subjecting the containers and the parts to a relatively high vacuum force. The containers are heat sealed while subjected to the vacuum force such that, upon sealing, hydrostatic pressure is exerted on the part. Following sealing of the packages, the packages and their contents are irradiated to an extent sufficient to sterilize the parts and to promote crosslinking within the part. Alternatively, the same property enhancements can be imparted to polymeric parts by packaging the part within rigid or flexible containers, minimizing the oxygen content within the containers, pressurizing the containers with an inert gas, or with a mixture of hydrogen and an inert gas, to greater than 1.5 atmospheres, and irradiating the part and the container.

    摘要翻译： 生物可植入聚合物部件的耐磨性和抗氧化性通过将容器包装在柔性不透气容器内，同时使容器和部件受到相对较高的真空力的改善。 容器在受到真空力的同时被热密封，使得在密封时，在该部件上施加静水压力。 在包装密封之后，将包装及其内容物照射到足以消除零件的程度并促进部件内的交联。 或者，可以通过将部件包装在刚性或柔性容器内，使容器内的氧含量最小化，用惰性气体或氢气和惰性气体的混合物对容器加压，或将氢气和惰性气体的混合物加压到 大于1.5个大气压，照射该部件和容器。