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    Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities
    2.
    发明申请
    Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
    具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力

    公开(公告)号：US20090093761A1

    公开(公告)日：2009-04-09

    申请号：US11973052

    申请日：2007-10-05

    申请人： John W. Sliwa ,  Bryan T. Oronsky ,  Herbert L. Berman ,  Neil C. Oronsky ,  Carol A Tosaya ,  George W. Keilman

    发明人： John W. Sliwa ,  Bryan T. Oronsky ,  Herbert L. Berman ,  Neil C. Oronsky ,  Carol A Tosaya ,  George W. Keilman

    IPC分类号： A61M5/32

    CPC分类号： A61M5/427 ,  A61B17/3403 ,  A61B90/30 ,  A61B2090/309 ,  A61B2090/373 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/325 ,  A61N1/36021

    摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.

    摘要翻译： 许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。 本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。 本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。 本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。 最后，还发现减轻疼痛的机制可用于管腔扩张。

    Systems and methods to deal with health-relevant fouling or plugging depositions and growths
    3.
    发明申请
    Systems and methods to deal with health-relevant fouling or plugging depositions and growths 审中-公开
    处理与健康有关的结垢或堵塞沉积和生长的系统和方法

    公开(公告)号：US20100233021A1

    公开(公告)日：2010-09-16

    申请号：US12381423

    申请日：2009-03-11

    申请人： John W. Sliwa ,  George W. Keilman ,  Bryan T. Oronsky ,  Carol A. Tosaya ,  Herbert L. Berman

    发明人： John W. Sliwa ,  George W. Keilman ,  Bryan T. Oronsky ,  Carol A. Tosaya ,  Herbert L. Berman

    IPC分类号： A61L2/10 ,  A61L2/03 ,  A61L2/025 ,  A61N1/32

    CPC分类号： A61M25/0017 ,  A61B90/70 ,  A61M27/00 ,  A61M37/00 ,  A61M2025/0019 ,  A61N1/205 ,  A61N1/32 ,  A61N1/40

    摘要： Disclosed are methods of inhibiting, avoiding or destroying existing, potential or incipient biodeposits, biofilms or pathogens any of (a) in or on a living body including in or on a medical device or implement placed, inserted or insertable in the body, (b) in, on or in contact with an ex vivo bodily tissue or fluid, or (c) in, on or in contact with a medium or matter to be consumed, ingested by or exposed to a living being or entity. Also disclosed are medical devices, implements, and prostheses that can be kept in a safe defouled, pathogen-free or pathogen-reduced condition with the help of an electric field(s). Also disclosed are medical or industrial devices, implements, equipment-articles and storage/handling-entities that can be kept in a safely defouled, pathogen-free or pathogen-reduced condition with the help of a membrane or orifice that has one or more of the antifouling or antipathogenic attributes.

    摘要翻译： 公开了抑制，避免或破坏现有的，潜在的或初期的生物沉积物，生物膜或病原体（a）在生物体内或之上的生物体，包括在放置，插入或插入体内的医疗装置或器具中或之上，（b） ）在离体身体组织或流体接触或接触时，或（c）在要消费的介质或物质中或与其接触或摄入或暴露于活体或实体时。 还公开了医疗装置，器具和假体，其可以在电场的帮助下保持在安全的防污染，无病原体或病原体减少的状态。 还公开了医疗或工业装置，器具，设备制品和储存/处理实体，其可以在具有一个或多个以下的膜或孔的帮助下保持在安全脱钩，无病原体或病原体减少的状态 防污或抗病原性。

    Acoustically-Aided and/or gel-aided delivery of beneficial gaseous, ionic, unstable, metastable, short-lived or reactive species for medical purposes
    4.
    发明申请
    Acoustically-Aided and/or gel-aided delivery of beneficial gaseous, ionic, unstable, metastable, short-lived or reactive species for medical purposes 审中-公开
    用于医疗目的的有利气体，离子，不稳定，亚稳态，短寿命或反应性物质的辅助和/或凝胶辅助递送

    公开(公告)号：US20080140026A1

    公开(公告)日：2008-06-12

    申请号：US12001701

    申请日：2007-12-11

    申请人： John W. Sliwa ,  Herbert L. Berman ,  Bryan T. Oronsky ,  Carol A. Tosaya

    发明人： John W. Sliwa ,  Herbert L. Berman ,  Bryan T. Oronsky ,  Carol A. Tosaya

    IPC分类号： A61M35/00

    CPC分类号： A61M37/0092 ,  A61M35/00

    摘要： An apparatus and method are provided for delivering to a patient's first bodily site and allowing bodily transport therefrom to one or more second bodily sites of a medically, physiologically, neurologically or other health-beneficial species, the at least one species or species precursor which would normally be one or more of volatile, gaseous, vaporous, sublimating, reactive, unacceptably degradable, toxic, hazardous, metastable or unstable if stored in unprotected ambient atmospheric conditions

    摘要翻译： 提供了一种装置和方法，用于递送给患者的第一身体部位，并允许从身体转运到医疗，生理学，神经学或其他健康有益物种的一个或多个第二身体部位，所述至少一种物种或物质前体将 通常是一种或多种挥发性，气态，气态，升华，反应性，不可接受的降解，有毒，危险，亚稳或不稳定，如果储存在无保护的环境大气条件

    Buoyant-capable beverage and food content-sensor
    5.
    发明申请
    Buoyant-capable beverage and food content-sensor 审中-公开
    具有浮力的饮料和食物含量传感器

    公开(公告)号：US20090266290A1

    公开(公告)日：2009-10-29

    申请号：US12150505

    申请日：2008-04-28

    申请人： John W. Sliwa ,  Bryan T. Oronsky ,  Herbert L. Berman ,  Neil C. Oronsky

    发明人： John W. Sliwa ,  Bryan T. Oronsky ,  Herbert L. Berman ,  Neil C. Oronsky

    IPC分类号： G01N33/00

    CPC分类号： G01N33/14 ,  G01N21/78 ,  G01N33/02

    摘要： A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).

    摘要翻译： 公开了一种可浮动的传感器系统装置，用于单独使用或在诸如秸秆，搅拌器，混合器，棒或器具的装置上使用，该装置检测饮料或液体食物如汤中是否存在一种或多种物质， 与饮料或食物直接或间接接触的感测元件和浮力传感器体，以确保感测元件的用户可视性。

    Organonitro thioether compounds and medical uses thereof
    6.
    发明授权
    Organonitro thioether compounds and medical uses thereof 有权
    有机硝基硫醚化合物及其医疗用途

    公开(公告)号：US09139519B2

    公开(公告)日：2015-09-22

    申请号：US14349004

    申请日：2012-05-18

    申请人： Jan Scicinski ,  Bryan T. Oronsky

    发明人： Jan Scicinski ,  Bryan T. Oronsky

    IPC分类号： A61K31/397 ,  C07D205/04 ,  A61K31/19 ,  A61K31/198 ,  A61K31/215 ,  A61K31/337 ,  A61K45/06 ,  A61N5/10

    CPC分类号： A61K31/397 ,  A61K31/19 ,  A61K31/198 ,  A61K31/215 ,  A61K31/337 ,  A61K38/05 ,  A61K45/06 ,  A61N5/10 ,  C07D205/04

    摘要： The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.

    摘要翻译： 本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。 本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。 本发明的另一方面提供了药物组合物，其包含本文所述的药学上可接受的载体和有机硫醚化合物，例如式I或II的化合物。 本发明的另一方面提供了一种治疗患者癌症的方法。 该方法包括向有需要的患者施用治疗有效量的本文所述的有机硝基硫醚化合物，例如式I或II的化合物，以治疗癌症。

    Formulation for decreasing tobacco, alcohol, drug or food consumption
    7.
    发明授权
    Formulation for decreasing tobacco, alcohol, drug or food consumption 失效
    减少烟草，酒精，药物或食物消费的配方

    公开(公告)号：US08784872B2

    公开(公告)日：2014-07-22

    申请号：US11942414

    申请日：2007-11-19

    申请人： Bryan T. Oronsky ,  Neil C. Oronsky ,  Arnold L. Oronsky

    发明人： Bryan T. Oronsky ,  Neil C. Oronsky ,  Arnold L. Oronsky

    IPC分类号： A61K9/00 ,  A61K47/00 ,  A61K9/68 ,  A61K36/00 ,  A61K31/4168 ,  A61K9/12 ,  A61K9/70

    CPC分类号： A61K47/34 ,  A24B15/16 ,  A61K9/0056 ,  A61K9/08 ,  A61K47/02 ,  A61K47/32 ,  A61K47/36

    摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick “highs”. The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.

    摘要翻译： 已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。 代表性的行为包括吸烟，过度酒精或食物摄入，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速“高”。 这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。 制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。 制剂含有亲水性聚合物，例如单独使用或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

    ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF
    9.
    发明申请
    ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF 有权
    ORGANONITRO THIOETHER化合物及其医疗用途

    公开(公告)号：US20140349988A1

    公开(公告)日：2014-11-27

    申请号：US14349004

    申请日：2012-05-18

    申请人： Jan Scicinski ,  Bryan T. Oronsky

    发明人： Jan Scicinski ,  Bryan T. Oronsky

    IPC分类号： C07D205/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/397

    CPC分类号： A61K31/397 ,  A61K31/19 ,  A61K31/198 ,  A61K31/215 ,  A61K31/337 ,  A61K38/05 ,  A61K45/06 ,  A61N5/10 ,  C07D205/04

    摘要： The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.

    摘要翻译： 本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。 本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。 本发明的另一方面提供了药物组合物，其包含本文所述的药学上可接受的载体和有机硫醚化合物，例如式I或II的化合物。 本发明的另一方面提供了一种治疗患者癌症的方法。 该方法包括向有需要的患者施用治疗有效量的本文所述的有机硝基硫醚化合物，例如式I或II的化合物，以治疗癌症。