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1.发明授权公开(公告)号：US09790534B2
公开(公告)日：2017-10-17
申请号：US14146367
申请日：2014-01-02
申请人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
发明人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
CPC分类号： C12Q1/04 , G01N33/6848 , H01J49/00
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements.
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2.发明申请公开(公告)号：US20140186879A1
公开(公告)日：2014-07-03
申请号：US14146367
申请日：2014-01-02
申请人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
发明人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , G01N33/6848 , H01J49/00
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements.
摘要翻译： 本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。 本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。 该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。 本发明还提供分离的微生物样品的光谱询问以产生微生物的测量，并使用所述光谱测量来表征和/或鉴定样品中的微生物。
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3.发明申请Method for separation, characterization and/or identification of microorganisms using raman spectroscopy 审中-公开使用拉曼光谱法分离，表征和/或鉴定微生物的方法公开(公告)号：US20100136609A1
公开(公告)日：2010-06-03
申请号：US12589976
申请日：2009-10-30
申请人： Bradford Clay , Jones Hyman , John Walsh , Thurman Thorpe , Christopher Ronsick
发明人： Bradford Clay , Jones Hyman , John Walsh , Thurman Thorpe , Christopher Ronsick
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for Raman spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said Raman spectroscopic measurements.
摘要翻译： 本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。 本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。 该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。 本发明进一步提供分离的微生物样品的拉曼光谱询问以产生微生物的测量，并使用所述拉曼光谱测量来表征和/或鉴定样品中的微生物。
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4.发明授权公开(公告)号：US10435733B2
公开(公告)日：2019-10-08
申请号：US14200662
申请日：2014-03-07
申请人： John Walsh , Jones Hyman , Bradford Clay , Thurman Thorpe
发明人： John Walsh , Jones Hyman , Bradford Clay , Thurman Thorpe
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle, that may be present in the sample.
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5.发明申请公开(公告)号：US20100120085A1
公开(公告)日：2010-05-13
申请号：US12589936
申请日：2009-10-30
申请人： Jones Hyman , Bradford Clay , John Walsh , Thurman Thorpe
发明人： Jones Hyman , Bradford Clay , John Walsh , Thurman Thorpe
CPC分类号： C12Q1/04 , G01N33/6848 , H01J49/00
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for interrogation of the separated microorganism sample by mass spectrometry to produce a mass spectrum of the microorganism and characterizing and/or identifying the microorganism in the sample using the mass spectrum obtained.
摘要翻译： 本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。 本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。 该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。 本发明还提供了通过质谱法对分离的微生物样品进行询问以产生微生物的质谱，并使用所获得的质谱来表征和/或鉴定样品中的微生物。
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公开(公告)号：US10415075B2
公开(公告)日：2019-09-17
申请号：US12589936
申请日：2009-10-30
申请人： Jones Hyman , Bradford Clay , John Walsh , Thurman Thorpe
发明人： Jones Hyman , Bradford Clay , John Walsh , Thurman Thorpe
摘要： A method is described to separate, characterize and/or identify microorganisms in a test sample. Said method comprises the steps of (i) lysing non-microorganism cells that might be present in the sample, (ii) separating the microorganisms as a pellet in the sample post-lysing non-microorganism cells, (iii) interrogating the pellet containing microorganisms by mass spectrometry to produce mass spectra of microorganisms, and (iv) characterizing and/or identifying microorganisms in the sample. The method may be used in characterizing/identifying microorganisms in complex samples, e.g., blood containing culture media.
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7.发明申请Method and System for Detection and/or Characterization of a Biological Particle in a Sample 审中-公开用于样品中生物颗粒检测和/或表征的方法和系统公开(公告)号：US20140186881A1
公开(公告)日：2014-07-03
申请号：US14200662
申请日：2014-03-07
申请人： John Walsh , Jones Hyman , Bradford Clay , Thurman Thorpe
发明人： John Walsh , Jones Hyman , Bradford Clay , Thurman Thorpe
CPC分类号： C12Q1/04 , C12Q1/10 , G01N21/31 , G01N21/47 , G01N21/64 , G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle, that may be present in the sample.
摘要翻译： 本发明提供了一种用于监测，检测和/或表征可能存在于样品中的生物颗粒的方法和系统，其中所述方法可以非侵入地通过利用时间依赖的光谱技术来获得至少两个测量 的生长组合物，其包含样品并将所述测量结果与可能存在于样品中的生物颗粒的检测和/或表征相关联。
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8.发明授权Methods for the characterization of microorganisms on solid or semi-solid media 有权在固体或半固体培养基上表征微生物的方法公开(公告)号：US08795983B2
公开(公告)日：2014-08-05
申请号：US13959802
申请日：2013-08-06
申请人： Jones Hyman , John Walsh , Thurman Thorpe
发明人： Jones Hyman , John Walsh , Thurman Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.
摘要翻译： 本发明涉及使用固有荧光（IF）测量在固体或半固体培养基上扫描，检测和监测微生物的方法和系统。 所述方法进一步涉及使用所述微生物特征的固有荧光（IF）测量法在固体或半固体培养基上检测，表征和/或鉴定微生物。
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公开(公告)号：US08748122B2
公开(公告)日：2014-06-10
申请号：US12653527
申请日：2009-12-15
申请人： Jones Hyman , John Walsh , Thurman Thorpe
发明人： Jones Hyman , John Walsh , Thurman Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.
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10.发明申请Methods for the Characterization of Microorganisms on Solid or Semi-Solid Media 有权固体或半固体培养基上微生物表征的方法公开(公告)号：US20130323718A1
公开(公告)日：2013-12-05
申请号：US13959802
申请日：2013-08-06
申请人： Jones Hyman , John Walsh , Thurman Thorpe
发明人： Jones Hyman , John Walsh , Thurman Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.
摘要翻译： 本发明涉及使用固有荧光（IF）测量在固体或半固体培养基上扫描，检测和监测微生物的方法和系统。 所述方法进一步涉及使用所述微生物特征的固有荧光（IF）测量法在固体或半固体培养基上检测，表征和/或鉴定微生物。
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