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    Assay Device and Method
    4.
    发明申请
    Assay Device and Method 审中-公开
    测定装置和方法

    公开(公告)号：US20100015728A1

    公开(公告)日：2010-01-21

    申请号：US12518389

    申请日：2007-12-19

    申请人： John William Dilleen ,  Phillip Lowe ,  Andrew Gill

    发明人： John William Dilleen ,  Phillip Lowe ,  Andrew Gill

    IPC分类号： G01N33/536 ,  B05D5/12 ,  B01J8/00 ,  G01N27/26

    CPC分类号： G01N33/54326 ,  G01N33/54366 ,  G01N33/84 ,  G01N2333/765 ,  G01N2800/2871 ,  G01N2800/32

    摘要： A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separating a portion of analyte-bound second reagent from excess second reagent. After the magnetic separation, the interaction of the analyte and the second reagent can be disrupted to produce a detectable form of the second reagent, which can be detected. A device and system suited to performing the method are also described.

    摘要翻译： 用于检测分析物的方法可以包括将分析物与与磁性颗粒相关联的第一试剂结合，允许分析物与能够与分析物相互作用的过量的第二试剂相互作用，以及磁分离一部分分析物 - 结合第二试剂从过量的第二试剂。 在磁分离之后，分析物和第二试剂的相互作用可能被破坏以产生可检测形式的第二试剂，其可被检测。 还描述了适于执行该方法的设备和系统。

    Analytical test strip with minimal fill-error sample viewing window
    5.
    发明授权
    Analytical test strip with minimal fill-error sample viewing window 有权
    具有最小填充误差样本查看窗口的分析测试条

    公开(公告)号：US08012428B2

    公开(公告)日：2011-09-06

    申请号：US12261293

    申请日：2008-10-30

    申请人： John William Dilleen ,  Lynsey Whyte ,  Robert Hamish MacLeod ,  Ramsay Raymond Donald Darling

    发明人： John William Dilleen ,  Lynsey Whyte ,  Robert Hamish MacLeod ,  Ramsay Raymond Donald Darling

    IPC分类号： G01N21/75 ,  G01N27/327

    CPC分类号： G01N27/3272 ,  C12Q1/005 ,  C12Q1/006

    摘要： An electrochemical-based analytical test strip includes an electrically-insulating substrate, a patterned conductive layer disposed over the electrically-insulating substrate, a patterned insulating layer disposed over the patterned conductive layer, an enzymatic reagent layer disposed over the patterned conductive layer, a patterned adhesive layer disposed above the enzymatic reagent layer and a top layer disposed over the enzymatic reagent layer. In addition, the test strip has a sample-receiving chamber defined by the electrically-insulating substrate, the patterned conductive layer, the patterned insulating layer, the enzymatic reagent layer, the patterned adhesive layer and the top layer. The sample receiving chamber of the test strip has a working portion and a non-working portion and the top layer has a first portion and an opaque second portion. The first portion is configured such that a user can view the working portion of the sample-receiving chamber through the first portion of the top layer, while the opaque second portion is configured to preclude a user from viewing the non-working portion of the sample-receiving chamber.

    摘要翻译： 基于电化学的分析测试条包括电绝缘衬底，设置在电绝缘衬底上的图案化导电层，设置在图案化导电层上的图案化绝缘层，设置在图案化导电层上的酶试剂层， 设置在酶试剂层上方的粘合剂层和设置在酶试剂层上的顶层。 此外，测试条具有由电绝缘基板，图案化导电层，图案化绝缘层，酶试剂层，图案化粘合剂层和顶层限定的样品接收室。 测试条的样品接收室具有工作部分和非工作部分，顶层具有第一部分和不透明的第二部分。 第一部分被配置成使得用户可以通过顶层的第一部分来观察样品接收室的工作部分，而不透明的第二部分被配置为阻止使用者观察样品的非工作部分 接收室

    Assays
    6.
    发明申请
    Assays 审中-公开
    测定

    公开(公告)号：US20100291611A1

    公开(公告)日：2010-11-18

    申请号：US12278883

    申请日：2007-02-15

    申请人： John Anthony Bolbot ,  John William Dilleen ,  Christopher John Slevin

    发明人： John Anthony Bolbot ,  John William Dilleen ,  Christopher John Slevin

    IPC分类号： C12Q1/02 ,  C12M1/00 ,  G01N33/48 ,  G01N33/20

    CPC分类号： G01N33/6803 ,  G01N33/02 ,  G01N33/18 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/54386 ,  G01N33/683 ,  G01N2333/765 ,  G01N2800/325

    摘要： A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the first detection zone and second electrodes arc in communication with the second detection zone. The device is configured to receive a blood derived sample introduced to the inlet, partition the blood sample into first and second blood sample portions, form a first mixture including at least some of the first blood sample portion and at least some of the cobalt reagent, and form a second mixture including at least some of the second blood sample portion, at least some of the cobalt reagent and at least some of the nickel reagent.

    摘要翻译： 一种装置包括至少部分地限定微流体网络的基底，该微流体网络包括与第一检测区域和第二检测区域连通的入口。 钴试剂和镍试剂置于微流体网络内。 第一电极与第一检测区域连通，第二电极与第二检测区域连通。 该装置被配置为接收引入到入口的血液衍生的样品，将血液样品分隔成​​第一和第二血液样本部分，形成包括第一血液样本部分和至少一些钴试剂中的至少一些的第一混合物， 并形成第二混合物，其包括至少一些第二血液样品部分，至少一些钴试剂和至少一些镍试剂。