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公开(公告)号：US07335762B2
公开(公告)日：2008-02-26
申请号：US10222592
申请日：2002-08-15
申请人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo , Michael P. Weiner
发明人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo , Michael P. Weiner
CPC分类号： G01N21/6452 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0893 , B82Y15/00 , B82Y30/00 , C12P19/34 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , G01N21/0303 , G01N21/7703 , C12Q2565/519 , C12Q2533/101 , C12Q2531/125 , C12Q2535/101 , C12Q2565/301 , C12Q2565/107 , C12Q2525/307
摘要： Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
摘要翻译： 本文公开了用于测序核酸的方法和装置。 这些方法允许非常大量的独立测序反应并行排列，允许非常大数量（> 10,000）不同寡核苷酸的同时测序。
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公开(公告)号：US07264929B2
公开(公告)日：2007-09-04
申请号：US10299180
申请日：2002-11-19
申请人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
发明人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
CPC分类号： G01N21/6452 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0893 , B82Y15/00 , B82Y30/00 , C12P19/34 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , G01N21/0303 , G01N21/7703 , C12Q2565/519 , C12Q2533/101 , C12Q2531/125 , C12Q2535/101 , C12Q2565/301 , C12Q2565/107 , C12Q2525/307
摘要： Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
摘要翻译： 本文公开了用于测序核酸的方法和装置。 这些方法允许非常大量的独立测序反应并行排列，允许非常大数量（> 10,000）不同寡核苷酸的同时测序。
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公开(公告)号：US07244559B2
公开(公告)日：2007-07-17
申请号：US09814338
申请日：2001-03-21
申请人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
发明人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
CPC分类号： G01N21/6452 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0893 , B82Y15/00 , B82Y30/00 , C12P19/34 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , G01N21/0303 , G01N21/7703 , C12Q2565/519 , C12Q2533/101 , C12Q2531/125 , C12Q2535/101 , C12Q2565/301 , C12Q2565/107 , C12Q2525/307
摘要： Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
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公开(公告)号：US07211390B2
公开(公告)日：2007-05-01
申请号：US10788529
申请日：2004-02-26
申请人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
发明人： Jonathan M. Rothberg , Joel S. Bader , Scott B. Dewell , Keith McDade , John W. Simpson , Jan Berka , Christopher M. Colangelo
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B82Y30/00 , C12Q1/6827 , C12Q1/6869 , C12Q1/6874 , G01N21/6452 , G01N2201/08 , G01N2201/0846 , C12Q2531/125 , C12Q2535/101 , C12Q2565/301 , C12Q2565/107 , C12Q2525/307
摘要： Disclosed herein are methods and apparatuses for sequencing a nucleic acid. In one aspect, the method includes annealing a population of circular nucleic acid molecules to a plurality of anchor primers linked to a solid support, and amplifying those members of the population of circular nucleic acid molecules which anneal to the target nucleic acid, and then sequencing the amplified molecules by detecting the presence of a sequence byproduct such as pyrophosphate.
摘要翻译： 本文公开了用于测序核酸的方法和装置。 一方面，该方法包括将多个环状核酸分子退火至与固体支持物连接的多个锚定引物，并扩增与靶核酸退火的环状核酸分子群体的那些成员，然后测序 通过检测序列副产物如焦磷酸盐的存在来扩增分子。
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