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32 条记录 (耗时 0.066 秒)

    Magnetoresistive flux focusing eddy current flaw detection
    2.
    发明授权
    Magnetoresistive flux focusing eddy current flaw detection 失效
    磁阻通量聚焦涡流探伤

    公开(公告)号：US06888346B2

    公开(公告)日：2005-05-03

    申请号：US10021683

    申请日：2001-11-28

    申请人： Russell A. Wincheski ,  Min Namkung ,  John W. Simpson

    发明人： Russell A. Wincheski ,  Min Namkung ,  John W. Simpson

    IPC分类号： G01N27/90 ,  G01N27/82

    CPC分类号： G01N27/9033

    摘要： A giant magnetoresistive flux focusing eddy current device effectively detects deep flaws in thick multilayer conductive materials. The probe uses an excitation coil to induce eddy currents in conducting material perpendicularly oriented to the coil's longitudinal axis. A giant magnetoresistive (GMR) sensor, surrounded by the excitation coil, is used to detect generated fields. Between the excitation coil and GMR sensor is a highly permeable flux focusing lens which magnetically separates the GMR sensor and excitation coil and produces high flux density at the outer edge of the GMR sensor. The use of feedback inside the flux focusing lens enables complete cancellation of the leakage fields at the GMR sensor location and biasing of the GMR sensor to a location of high magnetic field sensitivity. In an alternate embodiment, a permanent magnet is positioned adjacent to the GMR sensor to accomplish the biasing. Experimental results have demonstrated identification of flaws up to 1 cm deep in aluminum alloy structures. To detect deep flaws about circular fasteners or inhomogeneities in thick multilayer conductive materials, the device is mounted in a hand-held rotating probe assembly that is connected to a computer for system control, data acquisition, processing and storage.

    摘要翻译： 巨大的磁阻通量聚焦涡流装置有效地检测了厚层多层导电材料的深层缺陷。 探头使用激励线圈来引导垂直于线圈纵向轴线的材料中的涡流。 由激磁线圈包围的巨磁阻（GMR）传感器用于检测产生的场。 在励磁线圈和GMR传感器之间是一个高度透过的磁通聚焦透镜，它将GMR传感器和励磁线圈磁分离，并在GMR传感器的外缘产生高磁通密度。 使用通量聚焦透镜内的反馈能够完全消除GMR传感器位置处的泄漏场，并将GMR传感器偏置到高磁场灵敏度的位置。 在替代实施例中，永磁体被定位成与GMR传感器相邻以完成偏置。 实验结果表明，鉴定出铝合金结构深达1厘米深的缺陷。 为了检测厚多层导电材料中的圆形紧固件或不均匀性的深度缺陷，该装置安装在手持旋转探针组件中，该组件连接到计算机以进行系统控制，数据采集，处理和存储。

    Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
    4.
    发明授权
    Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing 失效
    用于鉴定，分类或定量样品中DNA序列的方法和设备，无需测序

    公开(公告)号：US06418382B2

    公开(公告)日：2002-07-09

    申请号：US09751561

    申请日：2000-12-29

    申请人： Jonathan Marc Rothberg ,  Michael W. Deem ,  John W. Simpson

    发明人： Jonathan Marc Rothberg ,  Michael W. Deem ,  John W. Simpson

    IPC分类号： G01N1506

    CPC分类号： G06F19/24 ,  C12N15/10 ,  C12Q1/68 ,  C12Q1/6809 ,  C12Q1/6855 ,  G06F19/22 ,  Y10S707/99936

    摘要： This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information.

    摘要翻译： 本发明提供了可以确定和分类混合样品或排列单序列克隆中的生物衍生DNA序列而不进行测序的方法。 这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库 在样品中确定样品序列。 优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。 然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。 聚合酶链反应（PCR）是优选的扩增方法。 本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。 提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息。

    Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
    6.
    发明授权
    Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing 失效
    用于鉴定，分类或定量样品中DNA序列而不进行测序的装置

    公开(公告)号：US5972693A

    公开(公告)日：1999-10-26

    申请号：US663823

    申请日：1996-06-14

    申请人： Jonathan Marc Rothberg ,  Michael W. Deem ,  John W. Simpson

    发明人： Jonathan Marc Rothberg ,  Michael W. Deem ,  John W. Simpson

    IPC分类号： G01N33/50 ,  C12M1/34 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/68 ,  G06F17/30 ,  G06F19/22 ,  C12M1/00 ,  G01N1/28 ,  H01L21/20

    CPC分类号： C12Q1/6855 ,  C12N15/10 ,  C12N15/1034 ,  C12Q1/68 ,  C12Q1/6809 ,  G06F19/24 ,  G06F19/22 ,  Y10S977/728 ,  Y10S977/924 ,  Y10T436/143333

    摘要： This invention provides methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Several alternative embodiments are described which capable of increased discrimination and which use TypeIIS restriction endonucleases, various capture moieties, or samples of specially synthesized cDNA. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information.

    摘要翻译： 本发明提供了可以确定和分类混合样品或排列单序列克隆中的生物衍生DNA序列而不进行测序的方法。 这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库 在样品中确定样品序列。 优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。 然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。 聚合酶链反应（PCR）是优选的扩增方法。 描述了能够增加鉴别和使用TypeIIS限制性内切核酸酶，各种捕获部分或特别合成的cDNA的样品的几种备选实施方案。 本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。 提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息。

    Radially focused eddy current sensor for detection of longitudinal flaws in metallic tubes
    7.
    发明授权
    Radially focused eddy current sensor for detection of longitudinal flaws in metallic tubes 失效
    用于检测金属管纵向缺陷的径向聚焦涡流传感器

    公开(公告)号：US5942894A

    公开(公告)日：1999-08-24

    申请号：US527741

    申请日：1995-09-13

    申请人： Russell A. Wincheski ,  John W. Simpson ,  James P. Fulton ,  Shridhar C. Nath ,  Ronald G. Todhunter ,  Min Namkung

    发明人： Russell A. Wincheski ,  John W. Simpson ,  James P. Fulton ,  Shridhar C. Nath ,  Ronald G. Todhunter ,  Min Namkung

    IPC分类号： G01N27/90 ,  G01N27/72 ,  G01R33/12

    CPC分类号： G01N27/902

    摘要： A radially focused eddy current sensor detects longitudinal flaws in a metal tube. A drive coil induces eddy currents within the wall of the metal tube. A pick-up coil is spaced apart from the drive coil along the length of the metal tube. The pick-up coil is positioned with one end thereof lying adjacent the wall of the metal tube such that the pick-up coil's longitudinal axis is perpendicular to the wall of the metal tube. To isolate the pick-up coil from the magnetic flux of the drive coil and the flux from the induced eddy currents, except the eddy currents diverted by a longitudinal flaw, an electrically conducting material high in magnetic permeability surrounds all of the pick-up coil except its one end that is adjacent the walls of the metal tube. The electrically conducting material can extend into and through the drive coil in a coaxial relationship therewith.

    摘要翻译： 径向聚焦的涡流传感器检测金属管中的纵向缺陷。 驱动线圈在金属管的壁内引起涡流。 拾取线圈沿着金属管的长度与驱动线圈间隔开。 拾取线圈的一端位于金属管的壁附近，使得拾取线圈的纵轴垂直于金属管的壁。 为了将拾取线圈与驱动线圈的磁通和来自感应涡流的磁通隔离，除了由纵向缺陷转移的涡流之外，导磁体的磁导率高，围绕着所有的拾取线圈 除了其与金属管的壁相邻的一端。 导电材料可以以与其同轴的关系延伸进入并穿过驱动线圈。

    Eddy Current Probe for Surface and Sub-Surface Inspection
    9.
    发明申请
    Eddy Current Probe for Surface and Sub-Surface Inspection 有权
    用于表面和子表面检测的涡流探头

    公开(公告)号：US20120274319A1

    公开(公告)日：2012-11-01

    申请号：US13457687

    申请日：2012-04-27

    申请人： Russell A. Wincheski ,  John W. Simpson

    发明人： Russell A. Wincheski ,  John W. Simpson

    IPC分类号： G01R33/12

    CPC分类号： G01R33/091 ,  G01R33/12

    摘要： An eddy current probe includes an excitation coil for coupling to a low-frequency alternating current (AC) source. A magnetoresistive sensor is centrally disposed within and at one end of the excitation coil to thereby define a sensing end of the probe. A tubular flux-focusing lens is disposed between the excitation coil and the magnetoresistive sensor. An excitation wire is spaced apart from the magnetoresistive sensor in a plane that is perpendicular to the sensor's axis of sensitivity and such that, when the sensing end of the eddy current probe is positioned adjacent to the surface of a structure, the excitation wire is disposed between the magnetoresistive sensor and the surface of the structure. The excitation wire is coupled to a high-frequency AC source. The excitation coil and flux-focusing lens can be omitted when only surface inspection is required.

    摘要翻译： 涡流探头包括用于耦合到低频交流（AC）源的激励线圈。 磁阻传感器居中设置在励磁线圈的一端内并在其一端，从而限定探头的感测端。 管状磁通聚焦透镜设置在励磁线圈和磁阻传感器之间。 励磁线在垂直于传感器的灵敏度轴的平面中与磁阻传感器间隔开，并且当涡流探针的感测端位于结构的表面附近时，激励线被布置 在磁阻传感器和结构的表面之间。 励磁线耦合到高频AC电源。 当仅需要表面检查时，可以省略励磁线圈和磁通聚焦透镜。

    Eddy Current System and Method for Crack Detection
    10.
    发明申请
    Eddy Current System and Method for Crack Detection 有权
    涡流系统和裂纹检测方法

    公开(公告)号：US20100079157A1

    公开(公告)日：2010-04-01

    申请号：US12493573

    申请日：2009-06-29

    申请人： Russell A. Wincheski ,  John W. Simpson

    发明人： Russell A. Wincheski ,  John W. Simpson

    IPC分类号： G01R27/08 ,  G01R33/18

    CPC分类号： G01N27/902 ,  G01N27/904

    摘要： An eddy current system and method enables detection of sub-surface damage in a cylindrical object. The invention incorporates a dual frequency, orthogonally wound eddy current probe mounted on a stepper motor-controlled scanning system. The system is designed to inspect for outer surface damage from the interior of the cylindrical object.

    摘要翻译： 涡流系统和方法能够检测圆柱形物体中的亚表面损伤。 本发明包括安装在步进电机控制扫描系统上的双频正交卷绕涡流探头。 该系统设计用于检查圆柱形物体内部的外表面损伤。