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公开(公告)号：US06765092B2
公开(公告)日：2004-07-20
申请号：US10011121
申请日：2001-12-07
IPC分类号： C07D48722
CPC分类号： C07D487/22 , B82Y10/00 , C07D519/00 , C09B47/00 , C09B69/109 , H01G9/2059 , H01G9/209 , H01L51/0077 , H01L51/009 , H01L51/0595 , Y02E10/542 , Y02P70/521
摘要： A method of making an oxochlorin comprises the steps of oxidizing a chlorin to produce a mixture of hydroxychlorin and oxochlorin, and then oxidizing the hydroxychlorin in said mixture, preferably with DDQ, to produce a mixture consisting essentially of oxochlorin. The step of oxidizing a chlorin is carried out by exposing the chlorin to alumina, typically in the presence of an oxidizing agent such as air or alumina. The oxidizing steps may be carried out in an organic solvent such as toluene. The chlorin is preferably a C-methylated chlorin, and is preferably metalated.
摘要翻译： 一种制备含氧色素的方法包括以下步骤：氧化二氢卟酚以产生羟基黄嘌呤和氧代二氢卟酚的混合物，然后氧化所述混合物中的羟基氯化物，优选用DDQ，以产生基本上由氧代黄嘌呤组成的混合物。 氧化二氢卟酚的步骤通过将二氢卟酚暴露于氧化铝，通常在氧化剂如空气或氧化铝的存在下进行。 氧化步骤可以在有机溶剂如甲苯中进行。 二氢卟酚优选为C-甲基化二氢卟酚，优选为金属化。
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公开(公告)号：US07408058B2
公开(公告)日：2008-08-05
申请号：US10760968
申请日：2004-01-20
IPC分类号： C07B47/00 , C07D345/00 , C07D517/00
CPC分类号： C07D487/22 , B82Y10/00 , C07D519/00 , C09B47/00 , C09B69/109 , H01G9/2059 , H01G9/209 , H01L51/0077 , H01L51/009 , H01L51/0595 , Y02E10/542 , Y02P70/521
摘要： A method of making an oxochlorin comprises the steps of oxidizing a chlorin to produce a mixture of hydronchlorin and oxochlorin, and then oxidizing the hydroxychlorin in said mixture, preferably with DDQ, to produce a mixture consisting essentially of oxochlorin. The step of oxidizing a chlorin is carried out by exposing the chlorin to alumina, typically in the presence of an oxidizing agent such as air or alumina. The oxidizing steps may be carried out in an organic solvent such as toluene. The chlorin is preferably a C-methylated chlorin, and is preferably metalated.
摘要翻译： 一种制备含氧色素的方法包括以下步骤：氧化二氢卟酚以产生羟基黄嘌呤和氧代二氢卟酚的混合物，然后氧化所述混合物中的羟基氯化物，优选用DDQ，以产生基本上由氧代黄嘌呤组成的混合物。 氧化二氢卟酚的步骤通过将二氢卟酚暴露于氧化铝，通常在氧化剂如空气或氧化铝的存在下进行。 氧化步骤可以在有机溶剂如甲苯中进行。 二氢卟酚优选为C-甲基化二氢卟酚，优选为金属化。
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公开(公告)号：US07534807B2
公开(公告)日：2009-05-19
申请号：US11357833
申请日：2006-02-17
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译： 通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。 缩合可以在有机溶剂中进行，优选在酸的存在下进行。 细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。
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公开(公告)号：US20090226467A1
公开(公告)日：2009-09-10
申请号：US12413903
申请日：2009-03-30
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A61K39/395 , A61K31/40 , A61K38/00 , A61K31/7088
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
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公开(公告)号：US08664260B2
公开(公告)日：2014-03-04
申请号：US13443085
申请日：2012-04-10
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A01N43/38 , A61K31/40 , C07B47/00 , C07D487/22
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译： 通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。 缩合可以在有机溶剂中进行，优选在酸的存在下进行。 细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。
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公开(公告)号：US08173691B2
公开(公告)日：2012-05-08
申请号：US12412770
申请日：2009-03-27
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A01N43/38 , A61K31/40 , C07D271/10 , C07D271/12 , C07D413/00 , C07D498/00
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译： 通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。 缩合可以在有机溶剂中进行，优选在酸的存在下进行。 细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。
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公开(公告)号：US20090191130A1
公开(公告)日：2009-07-30
申请号：US12412770
申请日：2009-03-27
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A61K49/00 , C07D487/22 , C07K16/00 , C07K17/00 , C07H21/00 , A61K31/409 , A61P35/00
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译： 通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。 缩合可以在有机溶剂中进行，优选在酸的存在下进行。 细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。
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公开(公告)号：US20120232463A1
公开(公告)日：2012-09-13
申请号：US13443085
申请日：2012-04-10
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A61M37/00 , C07D403/06 , C07K16/00 , C07K2/00 , C07K14/00 , C07H21/00 , C07F15/00 , C07F3/02 , C07F3/06 , C07F5/06 , C07F5/00 , C07F7/22 , C07F1/08 , C07F15/04 , C07F1/12 , A61K31/409 , A61K49/00 , G01N21/64 , A61P35/00 , A61P9/00 , A61P37/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/02 , A61P39/02 , C07D487/22
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译： 通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。 缩合可以在有机溶剂中进行，优选在酸的存在下进行。 细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。
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公开(公告)号：US08173692B2
公开(公告)日：2012-05-08
申请号：US12413903
申请日：2009-03-30
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
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公开(公告)号：US20140094462A1
公开(公告)日：2014-04-03
申请号：US13781000
申请日：2013-02-28
申请人： Sara Buhrlage , Chris Dockendorff , Mike Foley , Han-Je Kim , Andrew Germain , Lawrence MacPherson , Partha Nag , Stuart Schreiber , Amal Ting , Michel Weiwer , Willmen Youngsaye
发明人： Sara Buhrlage , Chris Dockendorff , Mike Foley , Han-Je Kim , Andrew Germain , Lawrence MacPherson , Partha Nag , Stuart Schreiber , Amal Ting , Michel Weiwer , Willmen Youngsaye
IPC分类号： C07D498/04 , C07D413/04 , C07D273/01
CPC分类号： C07D273/01 , C07D273/02 , C07D413/04 , C07D413/12 , C07D498/04 , C07D498/08
摘要： Sonic Hedgehog modulators and methods of use thereof are provided for.
摘要翻译： 提供了声刺猬调节剂及其使用方法。
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