公开(公告)号：US20060229686A1

公开(公告)日：2006-10-12

申请号：US11095306

申请日：2005-03-31

申请人： Jonathon Giftakis ,  Jonathan Werder ,  Paul Stypulkowski

发明人： Jonathon Giftakis ,  Jonathan Werder ,  Paul Stypulkowski

IPC分类号： A61N1/36

CPC分类号： A61N1/0539 ,  A61B5/4094 ,  A61B5/6864 ,  A61B2018/00434 ,  A61N1/0534 ,  A61N1/3605 ,  A61N1/36082 ,  A61N1/3752

摘要： An assembly for sensing physiologic signals and delivering monopolar stimulation therapy includes a pulse generator, a lead body that is coupled to the pulse generator and includes a first lead, at least one stimulating electrode coupled to the first lead and adapted to receive stimulating pulses from the pulse generator, and a remote electrode that is coupled to the pulse generator and positioned away from the pulse generator.

摘要翻译： 用于感测生理信号和递送单极刺激治疗的组件包括脉冲发生器，引线体，其连接到所述脉冲发生器并且包括第一引线，耦合到所述第一引线的至少一个刺激电极，并适于接收来自所述第一引线的刺激脉冲 脉冲发生器以及耦合到脉冲发生器并远离脉冲发生器定位的远程电极。

公开(公告)号：US20060224067A1

公开(公告)日：2006-10-05

申请号：US11380462

申请日：2006-04-27

申请人： Jonathon Giftakis ,  Jonathan Werder ,  Nina Graves ,  Eric Panken ,  David Carlson

发明人： Jonathon Giftakis ,  Jonathan Werder ,  Nina Graves ,  Eric Panken ,  David Carlson

IPC分类号： A61B5/02

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/3611 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a brain event time period by evaluation of the brain signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the brain event time period.

摘要翻译： 一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。 处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。 处理器还被配置为通过评估脑信号来确定大脑事件时间段的至少一个参考点。 处理器还基于大脑事件时间段的至少一个参考点识别心脏信号的第一部分。

公开(公告)号：US20070260286A1

公开(公告)日：2007-11-08

申请号：US11796575

申请日：2007-04-27

申请人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

发明人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

IPC分类号： A61N1/05

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61N1/365 ,  A61N1/37288

摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

公开(公告)号：US20060195039A1

公开(公告)日：2006-08-31

申请号：US11411712

申请日：2006-04-26

申请人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

发明人： Touby Drew ,  Jonathan Werder ,  Jonathon Giftakis ,  Eric Panken

IPC分类号： A61B5/04

CPC分类号： A61B5/04 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/37252 ,  A61N1/37282 ,  A61N1/3925 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

摘要： Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.

摘要翻译： 公开了生成扩展簇的方法。 产生包括表示表示异常生理症状的第一信号的数据的第一群集。 检测到第二信号表示第二异常生理症状，第二异常生理症状在第一异常生理症状终止后继续。 产生包括来自第一信号和第二信号的数据的扩展簇，其从第一异常生理症状发生时到第二异常生理症状结束时延伸。 第一和扩展簇可以包括簇的整个周期的第一和第二信号的数据。 如果需要，可以从植入患者脑组织的传感器提供第一信号或第二信号。

公开(公告)号：US20070265677A1

公开(公告)日：2007-11-15

申请号：US11796577

申请日：2007-04-27

申请人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

发明人： Jonathon Giftakis ,  Nina Graves ,  Jonathan Werder ,  Eric Panken

IPC分类号： A61N1/05

CPC分类号： A61B5/0402 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37288 ,  A61N1/3962

摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

摘要翻译： 使用脑状态信息调节或调节心脏治疗的系统。 调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是 调节心脏的治疗输出。

公开(公告)号：US20080033490A1

公开(公告)日：2008-02-07

申请号：US11741109

申请日：2007-04-27

申请人： Jonathon Giftakis ,  Nina Graves ,  David Thompson

发明人： Jonathon Giftakis ,  Nina Graves ,  David Thompson

IPC分类号： A61M31/00 ,  A61B5/08 ,  A61N1/00

CPC分类号： A61B5/0476 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/0478 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/05 ,  A61N1/3601 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/362 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system includes a housing, the housing at least partially supporting a therapy module and a processor, and a respiratory monitoring element coupled to the processor. The processor is configured to activate the therapy module upon detection of a respiratory event in a respiratory signal. In some embodiments, the system may further comprise a brain monitoring element, and the processor may be configured to monitor a brain signal and change the therapeutic output based upon the brain signal.

摘要翻译： 医疗装置系统包括壳体，壳体至少部分地支撑治疗模块和处理器，以及耦合到处理器的呼吸监测元件。 处理器被配置为在检测到呼吸信号中的呼吸事件时激活治疗模块。 在一些实施例中，系统还可以包括脑监测元件，并且处理器可以被配置为监视脑信号并且基于脑信号来改变治疗输出。

公开(公告)号：US20060235489A1

公开(公告)日：2006-10-19

申请号：US11412230

申请日：2006-04-26

申请人： Touby Drew ,  Jonathon Giftakis ,  Nina Graves

发明人： Touby Drew ,  Jonathon Giftakis ,  Nina Graves

IPC分类号： A61N1/36

CPC分类号： A61B5/04 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/4094 ,  A61B5/7232 ,  A61N1/36132 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/37252 ,  A61N1/37282 ,  A61N1/3925 ,  G06F19/00 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

摘要： Methods for receiving a patient mark in an implanted device. A patient may experience symptoms that indicative of a neurological event or are common precursors to more severe clinical symptoms. The patient may activate a patient activator. Activation of the patient activator can cause the patient activator to transmit the patient mark to an implanted device. The implanted device may adjust physiological data being stored in response to the patient mark, including data before and after the patient mark. The patient mark may be used to fine tune the detection algorithms and otherwise tune the detection capability of the implanted device and may also be used as an aid in statistical analysis of the stored physiological data.

摘要翻译： 用于在植入装置中接收患者标记的方法。 患者可能会出现指示神经系统事件的症状，或者是更严重临床症状的常见前兆。 患者可能激活患者激活剂。 患者激活剂的激活可导致患者活化剂将患者标记传递到植入装置。 植入装置可以响应于患者标记调整存储的生理数据，包括患者标记之前和之后的数据。 患者标记可以用于微调检测算法，否则调整植入装置的检测能力，并且也可以用作对存储的生理数据的统计分析的辅助。

公开(公告)号：US20060195144A1

公开(公告)日：2006-08-31

申请号：US11311043

申请日：2005-12-19

申请人： Jonathon Giftakis ,  Nina Graves

发明人： Jonathon Giftakis ,  Nina Graves

IPC分类号： A61N1/00 ,  A61M31/00 ,  A61B5/08

CPC分类号： A61B5/0476 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/0478 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/05 ,  A61N1/3601 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/362 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system includes a brain monitoring element, cardiopulmonary monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiopulmonary event in the cardiopulmonary signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiopulmonary triggered therapeutic output to the brain based upon the brain monitoring. Methods of treating a person with a neurological disorder are also provided.

摘要翻译： 医疗装置系统包括脑监测元件，心肺监测元件，治疗模块和处理器。 处理器被配置为在心肺信号中检测到心肺事件时激活治疗模块。 处理器进一步被配置为基于大脑监测来监测大脑信号并与治疗模块通信，以将心肺触发的治疗输出改变到大脑。 还提供了治疗患有神经障碍的人的方法。

公开(公告)号：US20060136006A1

公开(公告)日：2006-06-22

申请号：US11311200

申请日：2005-12-19

申请人： Jonathon Giftakis ,  Nina Graves

发明人： Jonathon Giftakis ,  Nina Graves

IPC分类号： A61N1/32

CPC分类号： A61B5/0476 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0245 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/0478 ,  A61B5/053 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/1135 ,  A61B5/4094 ,  A61N1/05 ,  A61N1/3601 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/362 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/37 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/37288 ,  A61N1/3962

摘要： A medical device system includes a brain monitoring element, cardiac monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiac event in the cardiac signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiac triggered therapeutic output to the brain based upon the brain monitoring. A method of treating a person with a neurological disorder is also provided.

摘要翻译： 医疗设备系统包括脑监测元件，心脏监测元件，治疗模块和处理器。 处理器被配置为在心脏信号中检测到心脏事件时激活治疗模块。 所述处理器进一步被配置为基于所述大脑监测来监测所述大脑信号并与所述治疗模块通信，以将所述心脏触发的治疗输出改变为大脑。 还提供了治疗患有神经障碍的人的方法。

公开(公告)号：US20080033508A1

公开(公告)日：2008-02-07

申请号：US11837994

申请日：2007-08-13

申请人： Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

发明人： Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

IPC分类号： A61N1/36

CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.