公开(公告)号：US08090435B2

公开(公告)日：2012-01-03

申请号：US12360826

申请日：2009-01-27

申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

IPC分类号： A61B5/0402

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

公开(公告)号：US07627366B1

公开(公告)日：2009-12-01

申请号：US11123300

申请日：2005-05-06

申请人： Annapurna Karicherla ,  Xiaoyi Min ,  Xiaozheng Zhang ,  Jong Gill

发明人： Annapurna Karicherla ,  Xiaoyi Min ,  Xiaozheng Zhang ,  Jong Gill

IPC分类号： A61N1/37

CPC分类号： A61N1/36507

摘要： An exemplary method includes providing a first value indicative of electrode polarization, delivering a cardiac stimulus and determining a second value indicative of electrode polarization associated with the cardiac stimulus, comparing the second value to the first value to determine whether a change in cardiac condition has occurred and, based at least in part on the comparing, deciding whether to adjust a cardiac stimulation therapy.

摘要翻译： 示例性方法包括提供指示电极极化的第一值，递送心脏刺激并确定指示与心脏刺激相关联的电极极化的第二值，将第二值与第一值进行比较，以确定心脏状态的变化是否已发生 并且至少部分地基于比较，决定是否调整心脏刺激疗法。

公开(公告)号：US20090177105A1

公开(公告)日：2009-07-09

申请号：US12360826

申请日：2009-01-27

申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

IPC分类号： A61B5/04

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

公开(公告)号：US20070027489A1

公开(公告)日：2007-02-01

申请号：US11192538

申请日：2005-07-28

申请人： Jong Gill ,  Xiaoyi Min

发明人： Jong Gill ,  Xiaoyi Min

IPC分类号： A61N1/00

CPC分类号： A61N1/365 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/0452 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and device for evaluating the progression of a patient's condition, which in certain applications can include heart failure, on an ongoing manner which reduces the need for immediate attention from skilled clinicians or expensive diagnostic equipment. The method and device analyze relative timing between electrical and mechanical properties of the heart. Detection of an elongated delay between corresponding electrical and mechanical activity is interpreted as indicating a worsening heart failure condition. The analysis and data corresponding thereto can be stored for further analysis and/or telemetrically communicated to an external device. Therapy provided by the device can be altered based on the evaluation of the patient's condition.

摘要翻译： 一种用于评估患者状况进展的方法和装置，其在某些应用中可以包括心力衰竭，以持续的方式减少熟练临床医生或昂贵诊断设备立即关注的需要。 该方法和装置分析心脏的电气和机械性质之间的相对时间。 在对应的电和机械活动之间的延长延迟的检测被解释为指示恶化的心力衰竭状况。 可以存储对应于其的分析和数据用于进一步分析和/或遥测地传送到外部设备。 可以根据对患者状况的评估来改变设备提供的治疗。

公开(公告)号：US07917216B1

公开(公告)日：2011-03-29

申请号：US11458649

申请日：2006-07-19

申请人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

发明人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

IPC分类号： A61N1/18

CPC分类号： A61N1/3622 ,  A61N1/0587 ,  A61N1/3686

摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.

摘要翻译： 通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。 电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。 电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。 或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

公开(公告)号：US07850616B1

公开(公告)日：2010-12-14

申请号：US11154064

申请日：2005-06-15

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Falkenberg Eric

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin ,  Falkenberg Eric

IPC分类号： A61B5/021 ,  A61B5/0225

CPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/0464 ,  A61B5/053 ,  A61B7/00 ,  A61N1/36578

摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于 至少部分地基于时间差，决定是否存在舒张异常。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07437192B2

公开(公告)日：2008-10-14

申请号：US11100008

申请日：2005-04-05

申请人： Jong Gill ,  Xiaoyi Min

发明人： Jong Gill ,  Xiaoyi Min

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61N1/3627 ,  A61N1/36521

摘要： Techniques are provided for detecting left ventricular end diastolic pressure (LV EDP) using a pressure sensor implanted within the heart of a patient and for detecting and evaluating heart failure and pulmonary edema based on LV EDP. Briefly, the peak of the R-wave of an intracardiac electrogram (IEGM) is used to trigger the measurement of a pressure value within the left ventricle. This pressure value is deemed to be representative of LV EDP. In this manner, LV EDP is easily detected merely by measuring pressure at one point within the heartbeat—thereby eliminating any need to track ventricular pressure throughout the heartbeat. Techniques for detecting and evaluating heart failure and pulmonary edema based on the R-wave triggered LV EDP measurements are also set forth herein.

摘要翻译： 提供了使用植入患者心脏内的压力传感器来检测左心室舒张压（LV EDP）的技术，并且用于基于LV EDP检测和评估心脏衰竭和肺水肿。 简而言之，使用心内电描记图（IEGM）的R波的峰值来触发左心室内的压力值的测量。 该压力值被认为是LV EDP的代表。 以这种方式，仅通过测量心跳内的一点的压力来容易地检测LV EDP，从而消除了跟踪整个心跳期间的心室压力的任何需要。 本文还介绍了基于R波触发的LV EDP测量来检测和评估心脏衰竭和肺水肿的技术。

公开(公告)号：US20080086177A1

公开(公告)日：2008-04-10

申请号：US11539824

申请日：2006-10-09

申请人： Xiaoyi Min ,  Paul A. Levine ,  Jong Gill

发明人： Xiaoyi Min ,  Paul A. Levine ,  Jong Gill

IPC分类号： A61N1/365

CPC分类号： A61N1/37 ,  A61B5/0452 ,  A61B5/0809 ,  A61B5/091 ,  A61B5/11 ,  A61N1/3621 ,  A61N1/3627

摘要： A system and related methods for monitoring cardiac disease. The system includes an implantable medical device having a microcontroller that is configured to measure a pacing latency value for a region of a heart, compare the measured pacing latency value to a previously measured pacing latency value for the region of the heart, and determine a change in an amount of cardiac disease in the region of the heart based on the comparison of the measured pacing latency values.

摘要翻译： 用于监测心脏病的系统和相关方法。 该系统包括具有微控制器的可植入医疗装置，微控制器被配置为测量心脏区域的起搏延迟值，将测量的起搏延迟值与心脏区域的先前测量的起搏延迟值进行比较，并确定改变 基于测量的起搏延迟值的比较，在心脏区域中的心脏病的量。

公开(公告)号：US07648464B1

公开(公告)日：2010-01-19

申请号：US11458617

申请日：2006-07-19

申请人： Jong Gill ,  Peter Boileau ,  Gene A. Bornzin ,  Joseph J. Florio ,  Xiaoyi Min

发明人： Jong Gill ,  Peter Boileau ,  Gene A. Bornzin ,  Joseph J. Florio ,  Xiaoyi Min

IPC分类号： A61B5/021

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/042 ,  A61B5/7239 ,  A61N1/36564

摘要： Methods and systems are presented for using an ICD to detect myocardial ischemia. In one embodiment, a method includes sensing a signal indicative of cardiac pressure, measuring a height of the sensed signal at a peak amplitude of the sensed signal, and measuring a duration of the sensed signal. The method further includes indicating an ischemia based on a comparison of a ratio of the height to the duration with a predetermined value. In another embodiment, a method includes sensing a signal indicative of cardiac pressure, determining a derivative signal that is a first derivative of the sensed signal, measuring a maximum positive value of the derivative signal, and measuring a maximum negative value of the derivative signal. The method further includes indicating an ischemia based on a comparison of a ratio of the maximum positive value to the maximum negative value with a predetermined value.

摘要翻译： 提出了使用ICD检测心肌缺血的方法和系统。 在一个实施例中，一种方法包括感测指示心脏压力的信号，以感测信号的峰值幅度测量感测信号的高度，以及测量感测信号的持续时间。 该方法还包括基于将高度与持续时间的比率与预定值的比较来指示缺血。 在另一个实施例中，一种方法包括感测指示心脏压力的信号，确定作为感测信号的一阶导数的导数信号，测量导数信号的最大正值，以及测量导数信号的最大负值。 该方法还包括基于将最大正值与最大负值的比率与预定值进行比较来指示缺血。

公开(公告)号：US07526338B1

公开(公告)日：2009-04-28

申请号：US11136268

申请日：2005-05-23

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61B5/0215 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/36564 ,  G06F19/3481 ,  G16H50/50

摘要： An implantable cardiac device is used to measure one or more parameters relating to cardiac activity of a patient's heart, from which diastolic heart failure (“DHF”) may be monitored and/or detected. These parameters are used to calculate ventricular isovolumetric relaxation time or a related time value. Heart conditions possibly having an influence on the ventricular isovolumetric relaxation time, other than heart conditions due to reduced compliance, may be detected and used to prevent an incorrect calculation of the ventricular isovolumetric relaxation time. The parameters may be measured and the relaxation time calculated multiple times over a period of time, which enables monitoring of the progression of change in the relaxation time. The relaxation time and the progression of change therein are indicators of DHF.

摘要翻译： 可植入心脏装置用于测量与患者心脏的心脏活动相关的一个或多个参数，可以从该心脏的心脏监测和/或检测舒张性心力衰竭（“DHF”）。 这些参数用于计算心室等容弛豫时间或相关时间值。 可能检测并用于可能对心室等容舒张时间（由于依从性降低而导致的心脏状况）影响的心脏状况，以防止心室等容性弛豫时间的错误计算。 可以测量参数并且在一段时间内多次计算松弛时间，这可以监测松弛时间的变化进展。 舒缓时间及其变化的进展情况是DHF的指标。