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公开(公告)号：US20180051028A1
公开(公告)日：2018-02-22
申请号：US15557197
申请日：2016-03-07
申请人： JONGWON LIM , MICHAEL D. ALTMAN , JASON D. BRUBAKER , CRAIG R. GIBEAU , MERCK SHARP & DOHME CORP.
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K31/551 , C07D519/00 , A61K31/55 , A61K31/553
CPC分类号： C07D487/04 , A61K31/519 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , A61P29/00 , C07D519/00
摘要： The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051035A1
公开(公告)日：2018-02-22
申请号：US15557206
申请日：2016-03-07
发明人： JONGWON LIM , MICHAEL D. ALTMAN , CRAIG R. GIBEAU
IPC分类号： C07D495/04 , A61K31/4985 , A61K45/06 , A61K31/551 , C07D519/00 , A61K31/55
CPC分类号： C07D495/04 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/55 , A61K31/551 , A61K45/06 , A61P29/00 , C07D519/00 , A61K2300/00
摘要： The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051030A1
公开(公告)日：2018-02-22
申请号：US15557203
申请日：2016-03-07
IPC分类号： C07D487/04 , C07D403/14 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , A61P29/00 , C07D403/14 , A61K2300/00
摘要： The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051027A1
公开(公告)日：2018-02-22
申请号：US15557195
申请日：2016-03-07
申请人： JONGWON LIM , MICHAEL D. ALTMAN , MATTHEW L. CHILDERS , CRAIG R. GIBEAU , GINNY DAI HO , HONCHUNG TSUI , MERCK SHARP & DOHME CORP.
发明人： JONGWON LIM , MICHAEL D. ALTMAN , MATTHEW L. CHILDERS , CRAIG R. GIBEAU , GINNY DAI HO , HONCHUNG TSUI
IPC分类号： C07D487/04 , A61K45/06 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D495/04 , A61K31/4985 , A61K31/53
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/635 , A61K45/06 , C07D495/04
摘要： The present invention relates to carboxamide inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20180051029A1
公开(公告)日：2018-02-22
申请号：US15557201
申请日：2016-03-07
申请人： JONGWON LIM , MICHAEL D. ALTMAN , JASON D. BRUBAKER , CRAIG R. GIBEAU , MERCK SHARP & DOHME CORP.
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5025 , C07D519/00 , A61K31/551 , A61K31/55
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/55 , A61K31/551 , A61K45/06 , C07D519/00
摘要： The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20170217981A1
公开(公告)日：2017-08-03
申请号：US15515377
申请日：2015-09-25
申请人： Craig R. GIBEAU , Solomon D. KATTAR , Charles A. KATTAR , Jongwon LIM , John K. MACLEAN , Umar F. MANSOOR , Alan B. NORTHRUP , John M. SANDERS , Graham F. SMITH , MERCK SHARP & DOHME CORP.
发明人： MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
IPC分类号： C07D491/08 , A61K31/517 , A61K45/06 , C07D239/88 , A61K31/5377 , C07D403/12 , C07D401/12 , C07D413/12 , A61K31/538 , C07D491/052 , A61K31/5386 , C07D491/048 , A61K31/55 , C07D405/12 , C07D239/94
CPC分类号： C07D491/08 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/55 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D491/048 , C07D491/052 , C07D498/08 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibutors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20170275297A1
公开(公告)日：2017-09-28
申请号：US15515383
申请日：2015-09-25
申请人： Michael D. ALTMAN , Brian M. ANDRESEN , Jason D. BRUBAKER , Matthew L. CHILDERS , Anthony DONOFRIO , Thierry FISCHMANN , Craig R. GIBEAU , Solomon D. KATTAR , Charles A. LESBURG , Jongwon LIM , John K.F. MACLEAN , Umar F. MANSOOR , Alan B. NORTHRUP , John SANDERS , Graham F. SMITH , Luis TORRES
发明人： MICHAEL D. ALTMAN , BRIAN M. ANDRESEN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , LUIS TORRES
IPC分类号： C07D498/04 , A61K31/517 , C07D403/04 , C07D239/94 , C07D401/04 , A61K31/5377 , C07D405/14 , C07D401/14 , C07D413/04 , C07D405/04 , C07D471/04 , A61K31/5383 , C07D491/048 , C07D417/04 , C07D409/04 , A61K45/06
CPC分类号： C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P37/00 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/048 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20170247388A1
公开(公告)日：2017-08-31
申请号：US15515396
申请日：2015-09-25
申请人： MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
发明人： MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
IPC分类号： C07D491/107 , C07D239/94 , A61K31/5377 , C07D417/12 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/541 , A61K31/517 , C07D403/12
CPC分类号： C07D491/107 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , A61P19/00 , A61P29/00 , A61P35/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：US20170209446A1
公开(公告)日：2017-07-27
申请号：US15515388
申请日：2015-09-25
发明人： MICHAEL D. ALTMAN , BRIAN M. ANDRESEN , JASON D. BRUBAKER , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH , LUIS TORRES
IPC分类号： A61K31/517 , C07D239/94 , C07D405/04 , A61K45/06
CPC分类号： A61K31/517 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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