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公开(公告)号:US20170247388A1
公开(公告)日:2017-08-31
申请号:US15515396
申请日:2015-09-25
申请人: MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
发明人: MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
IPC分类号: C07D491/107 , C07D239/94 , A61K31/5377 , C07D417/12 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/541 , A61K31/517 , C07D403/12
CPC分类号: C07D491/107 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , A61P19/00 , A61P29/00 , A61P35/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K2300/00
摘要: The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号:US20170275297A1
公开(公告)日:2017-09-28
申请号:US15515383
申请日:2015-09-25
申请人: Michael D. ALTMAN , Brian M. ANDRESEN , Jason D. BRUBAKER , Matthew L. CHILDERS , Anthony DONOFRIO , Thierry FISCHMANN , Craig R. GIBEAU , Solomon D. KATTAR , Charles A. LESBURG , Jongwon LIM , John K.F. MACLEAN , Umar F. MANSOOR , Alan B. NORTHRUP , John SANDERS , Graham F. SMITH , Luis TORRES
发明人: MICHAEL D. ALTMAN , BRIAN M. ANDRESEN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , LUIS TORRES
IPC分类号: C07D498/04 , A61K31/517 , C07D403/04 , C07D239/94 , C07D401/04 , A61K31/5377 , C07D405/14 , C07D401/14 , C07D413/04 , C07D405/04 , C07D471/04 , A61K31/5383 , C07D491/048 , C07D417/04 , C07D409/04 , A61K45/06
CPC分类号: C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P37/00 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/048 , A61K2300/00
摘要: The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号:US20170217981A1
公开(公告)日:2017-08-03
申请号:US15515377
申请日:2015-09-25
申请人: Craig R. GIBEAU , Solomon D. KATTAR , Charles A. KATTAR , Jongwon LIM , John K. MACLEAN , Umar F. MANSOOR , Alan B. NORTHRUP , John M. SANDERS , Graham F. SMITH , MERCK SHARP & DOHME CORP.
发明人: MICHAEL D. ALTMAN , JASON D. BRUBAKER , MATTHEW L. CHILDERS , ANTHONY DONOFRIO , THIERRY FISCHMANN , CRAIG R. GIBEAU , SOLOMON D. KATTAR , CHARLES A. LESBURG , JONGWON LIM , JOHN K.F. MACLEAN , UMAR F. MANSOOR , ALAN B. NORTHRUP , JOHN M. SANDERS , GRAHAM F. SMITH
IPC分类号: C07D491/08 , A61K31/517 , A61K45/06 , C07D239/88 , A61K31/5377 , C07D403/12 , C07D401/12 , C07D413/12 , A61K31/538 , C07D491/052 , A61K31/5386 , C07D491/048 , A61K31/55 , C07D405/12 , C07D239/94
CPC分类号: C07D491/08 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/55 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D491/048 , C07D491/052 , C07D498/08 , A61K2300/00
摘要: The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibutors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号:US20180079752A1
公开(公告)日:2018-03-22
申请号:US15578775
申请日:2016-05-31
申请人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
发明人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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