公开(公告)号：US6069194A

公开(公告)日：2000-05-30

申请号：US990012

申请日：1997-12-12

申请人： Michael R. Franzen ,  Donn R. Vermilion ,  David C. Trumbore ,  Richard T. Janicki ,  Jeffrey W. Smith ,  Jay W. Keating ,  Jorge A. Marzari ,  Thomas C. Bitsky ,  Ron S. Bliss

发明人： Michael R. Franzen ,  Donn R. Vermilion ,  David C. Trumbore ,  Richard T. Janicki ,  Jeffrey W. Smith ,  Jay W. Keating ,  Jorge A. Marzari ,  Thomas C. Bitsky ,  Ron S. Bliss

IPC分类号： B65D85/84 ,  C08L57/00 ,  C08L91/06 ,  C08L95/00

CPC分类号： C08L95/00

摘要： A method and apparatus for packaging a low-fuming meltable asphalt composition which includes the introduction of pellets comprising one or more polymeric materials into molten asphalt flowed into a conventional container or carton.

摘要翻译： 一种用于包装低发泡可熔沥青组合物的方法和装置，其包括将包含一种或多种聚合物材料的粒料引入流入常规容器或纸箱的熔融沥青中。

公开(公告)号：US5611910A

公开(公告)日：1997-03-18

申请号：US599773

申请日：1996-02-12

申请人： Jorge A. Marzari ,  Michael R. Franzen ,  Jeffrey W. Smith

发明人： Jorge A. Marzari ,  Michael R. Franzen ,  Jeffrey W. Smith

IPC分类号： B01D53/50 ,  C10C3/02 ,  C10C3/04 ,  C10C1/20

CPC分类号： C10C3/04 ,  B01D53/501 ,  B01D53/507 ,  C10C3/023

摘要： In a method for reducing emissions from an asphalt blowing process, an emission reducing additive is added to the asphalt prior to blowing, or early in the blowing process. The emission reducing additive is added in an amount sufficient to reduce the SO.sub.x emissions from the blowing process by at least 25 percent by weight when compared with the same process without the emission reducing additive. The emission reducing additive includes at least two compounds selected from metal hydroxides, metal oxides, metal carbonates and metal bicarbonates, where the metal is selected from sodium, potassium, calcium, magnesium, zinc, copper and aluminum.

摘要翻译： 在减少沥青吹制过程的排放的方法中，在吹制之前或在吹制过程的早期，将沥青添加到沥青中。 当与不含减排添加剂的相同方法相比时，减少排放添加剂的量足以将来自吹制过程的SO x排放量减少至少25重量％。 减排添加剂包括选自金属氢氧化物，金属氧化物，金属碳酸盐和金属碳酸氢盐中的至少两种化合物，其中金属选自钠，钾，钙，镁，锌，铜和铝。

公开(公告)号：US08563248B2

公开(公告)日：2013-10-22

申请号：US12959349

申请日：2010-12-02

申请人： Jeffrey W. Smith ,  Changming Fang

发明人： Jeffrey W. Smith ,  Changming Fang

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

公开(公告)号：US08119653B2

公开(公告)日：2012-02-21

申请号：US11775154

申请日：2007-07-09

申请人： Daniel Romo ,  Sung Wook Cho ,  Jeffrey W. Smith ,  Robyn D. Richardson

发明人： Daniel Romo ,  Sung Wook Cho ,  Jeffrey W. Smith ,  Robyn D. Richardson

IPC分类号： A61K31/436 ,  C07D221/18

CPC分类号： C07D407/12 ,  C07D305/12

摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.

摘要翻译： 披露了双乳糖蛋白衍生物及其合成。 在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。 通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。 在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。 还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

公开(公告)号：US07799826B2

公开(公告)日：2010-09-21

申请号：US10418513

申请日：2003-04-16

申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

IPC分类号： A61K31/335

CPC分类号： A61K31/337 ,  A61K31/335 ,  A61K31/336 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis.

摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。

公开(公告)号：US20100069120A1

公开(公告)日：2010-03-18

申请号：US12622956

申请日：2009-11-20

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04B1/38 ,  H04B1/713

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.

摘要翻译： 提供了一种用于校准跳频自适应基站的射频路径的方法。 校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。 无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。 校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。 校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数 或更多的频率。 还提供了自校准跳频自适应基站收发台。

公开(公告)号：US06487187B1

公开(公告)日：2002-11-26

申请号：US09198808

申请日：1998-11-24

申请人： Thomas R. Schmutz ,  Michael A. Komara ,  Roger L. Overton ,  Jeffrey W. Smith ,  David D. Coons ,  Jeffrey R. Nuckols

发明人： Thomas R. Schmutz ,  Michael A. Komara ,  Roger L. Overton ,  Jeffrey W. Smith ,  David D. Coons ,  Jeffrey R. Nuckols

IPC分类号： H04B7212

CPC分类号： H04B7/2656 ,  H04W16/26 ,  H04W52/325

摘要： In a conventional Time Division Multiple Access (TDMA) wireless system, the specified distance between a mobile unit and the base transceiver system (BTS) cannot exceed predetermined distances because of time slot synchronization constraints. Furthermore, the varying distances between mobile units and the BTS create timing differences in the random access control channel (RACCH) bursts in the initial uplink signal from the mobile stations. In this approach to extending TDMA system coverage, in-band translator components are located in the center of remote cells which would normally contain a base transceiver system. The in-band translators include a loop back circuit that permits a host BTS to measure the backhaul propagation time delay by sending test access signals between the host BTS and the distant in-band translators. After backhaul timing delay is compensated in the BTS, then the in-band translator uses downlink time slot recovery to synchronize slot-by-slot uplink diversity selection and automatic level control. Recovery of timing bursts on downlink from the BTS allows for determination of burst, frame, and multiframe timing for downlink and uplink in the in-band translator. Processing allows for pre-determination of which uplink time slots that the RAACH signal can appear from the mobile unit. This method allows for automatic level control during RAACH bursts in addition to normal uplink bursts.

摘要翻译： 在传统的时分多址（TDMA）无线系统中，由于时隙同步约束，移动单元与基站收发器系统（BTS）之间的指定距离不能超过预定距离。 此外，移动单元和BTS之间的变化的距离在来自移动台的初始上行链路信号中在随机接入控制信道（RACCH）突发中产生定时差。 在这种扩展TDMA系统覆盖的方法中，带内转换器组件位于通常包含基站收发器系统的远程小区的中心。 带内转换器包括回送电路，其允许主机BTS通过在主机BTS和远端带内转换器之间发送测试接入信号来测量回程传播时间延迟。在BTS中补偿回程定时延迟后， 带内转换器使用下行链路时隙恢复来同步逐个时隙上行链路分集选择和自动电平控制。来自BTS的下行链路上的定时突发的恢复允许确定下行链路和上行链路的突发，帧和多帧定时 带内翻译器。 处理允许预先确定RAACH信号可以从移动单元出现哪些上行链路时隙。 该方法允许除了正常的上行链路突发之外的RAACH突发期间的自动电平控制。

公开(公告)号：US5477586A

公开(公告)日：1995-12-26

申请号：US276932

申请日：1994-07-19

申请人： Scott Jacobs ,  Joyce Thomas ,  Jeffrey W. Smith

发明人： Scott Jacobs ,  Joyce Thomas ,  Jeffrey W. Smith

IPC分类号： A47L5/32

CPC分类号： A47L5/32

摘要： A socket is provided on the upright portion of a vacuum cleaner for the insertion of the wand on the distal end of the accessory hose. The wand, which is normally inserted into the socket when the accessories are not being used, engages a linkage mechanism within the socket. The linkage mechanism closes a valve door within the suction stream when the wand is removed to close the suction passageway from the vacuum source to the base and open the suction passageway to the hose. The linkage mechanism opens the valve door when the wand is replaced to close the suction passageway to the hose and open the suction passageway to the base. The present invention automatically closes the suction passage from the floor engaging portion whenever the accessories are being used and assures that the suction connections are always in the proper position for floor cleaning or above-floor cleaning.

摘要翻译： 在真空吸尘器的直立部分上设置插座，用于将棒插入附件软管的远端。 当配件未使用时，通常插入插座的魔杖与插座内的连杆机构相接合。 当移除魔杖以将吸入通道从真空源关闭到基座并且将抽吸通道打开到软管时，联动机构关闭吸入流内的阀门。 当更换棒时，连接机构打开阀门，以将抽吸通道关闭到软管，并将吸入通道打开到基座。 每当使用附件时，本发明自动地从地板接合部分关闭吸入通道，并且确保吸入连接始终处于用于地板清洁或地板上清洁的适当位置。

公开(公告)号：US08712475B2

公开(公告)日：2014-04-29

申请号：US13350489

申请日：2012-01-13

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04B1/38

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A base transceiver station including a transceiver unit is provided. A method of calibration uses a transceiver unit to receive an RF signal, measure a calibration value, and transmit the measured value. The calibration value is used to determine weighting parameters to compensate for relative RF path phase delay and amplitude variation.

摘要翻译： 提供了包括收发器单元的基站收发器。 校准方法使用收发器单元来接收RF信号，测量校准值并传输测量值。 校准值用于确定加权参数以补偿相对RF路径相位延迟和幅度变化。

公开(公告)号：US07935785B2

公开(公告)日：2011-05-03

申请号：US12252160

申请日：2008-10-15

申请人： Jeffrey W. Smith ,  Emily I. Chen ,  Steven J. Kridel

发明人： Jeffrey W. Smith ,  Emily I. Chen ,  Steven J. Kridel

IPC分类号： C07K5/00 ,  C07K14/00

CPC分类号： A61K49/0021 ,  A61K47/64 ,  A61K49/0056 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0821 ,  C07K5/0823 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/37

摘要： The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.

摘要翻译： 本发明提供分离的MMP-2，MMP-9和MT1-MMP选择性底物多肽或功能肽模拟物。 选择性底物多肽包含以下序列：MMP-2选择性底物多肽含有SEQ ID NO：1-27，含有SEQ ID NO：28-35的MMP-9选择性底物多肽，并且含有SEQ ID NOS的MT1-MMP选择性底物多肽 ：36-40。 此外，本发明提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：45-47的分离的MMP-2选择性底物多肽来优先将部分定向到MMP-2活性位点的方法 。 还提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：44的分离的MMP-9选择性底物多肽，优先将一部分连接至部分MMP-9活性部位的方法， 通过向受试者施用有效量的与部分连接的含有SEQ ID NO：36-40的分离的MT1-MMP选择性底物多肽，从而部分到MT1-MMP活性的位点。