-
公开(公告)号:US20050282874A1
公开(公告)日:2005-12-22
申请号:US11094241
申请日:2005-03-31
申请人: Joseph Barbosa , Cynthia Fink , Spencer Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok Tunoori
发明人: Joseph Barbosa , Cynthia Fink , Spencer Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok Tunoori
IPC分类号: A61K31/429 , C07D513/02 , C07D513/04
CPC分类号: C07D513/04
摘要: This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
摘要翻译: 本发明涉及新型噻唑并吡唑化合物及其组合物。 使用这些化合物治疗,预防和治疗各种疾病和病症的方法也包括在本发明中。
-
公开(公告)号:US07300949B2
公开(公告)日:2007-11-27
申请号:US11094241
申请日:2005-03-31
申请人: Joseph Barbosa , Cynthia A. Fink , Spencer D. Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok R. Tunoori
发明人: Joseph Barbosa , Cynthia A. Fink , Spencer D. Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok R. Tunoori
IPC分类号: C07D513/02 , A61K31/429
CPC分类号: C07D513/04
摘要: This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
摘要翻译: 本发明涉及新型噻唑并吡唑化合物及其组合物。 使用这些化合物治疗,预防和治疗各种疾病和病症的方法也包括在本发明中。
-
公开(公告)号:US08629156B2
公开(公告)日:2014-01-14
申请号:US13290261
申请日:2011-11-07
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12 , A61K31/505 , A61P1/00
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
-
公开(公告)号:US20100280054A1
公开(公告)日:2010-11-04
申请号:US12750278
申请日:2010-03-30
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: A61K31/505 , C07D239/47 , A61P1/00
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
-
公开(公告)号:US07723345B2
公开(公告)日:2010-05-25
申请号:US11638677
申请日:2006-12-12
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/505 , C07D239/02
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
-
公开(公告)号:US20100087433A1
公开(公告)日:2010-04-08
申请号:US12571912
申请日:2009-10-01
申请人: Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
发明人: Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
IPC分类号: A61K31/5377 , A61K31/4418 , A61K31/444 , A61P25/00
CPC分类号: C07D401/06 , C07D213/74 , C07D213/89 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/14
摘要: Compounds, compositions and methods of treating serotonin-mediated diseases and disorders are disclosed.
摘要翻译: 公开了治疗5-羟色胺介导的疾病和病症的化合物,组合物和方法。
-
公开(公告)号:US20070191370A1
公开(公告)日:2007-08-16
申请号:US11638677
申请日:2006-12-12
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: A61K31/53 , A61K31/506 , A61K31/501 , A61K31/4965 , A61K31/497 , A61K31/4439 , C07D403/02
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
-
8.4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US08772482B2
公开(公告)日:2014-07-08
申请号:US13162989
申请日:2011-06-17
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D403/12 , A61K31/506 , A61P1/04 , A61P1/06 , A61K31/4152
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
-
9.Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds 有权
标题翻译: 使用4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物的方法公开(公告)号:US07968559B2
公开(公告)日:2011-06-28
申请号:US12754341
申请日:2010-04-05
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , A61P35/00 , A61P1/00 , C07D403/12
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
-
10.Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds 有权
标题翻译: 使用4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物的方法公开(公告)号:US20100311764A1
公开(公告)日:2010-12-09
申请号:US12754341
申请日:2010-04-05
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , A61P1/00 , A61P35/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
-
-
-
-
-
-
-
-
-