公开(公告)号：US4840911A

公开(公告)日：1989-06-20

申请号：US55811

申请日：1987-05-28

Applicant: Joseph Epstein ,  John A. Parsons ,  Frank Block

Inventor： Joseph Epstein ,  John A. Parsons ,  Frank Block

IPC: G01N27/62

CPC classification number: G01N27/626 ,  Y10T436/10 ,  Y10T436/100833

Abstract: A method of simulating a positive response by volatile organophosphorus ers to an ionization detector system which comprises forwarding to the ionization detector system a gaseous stream comprising water vapor and a di(lower alkyl) sulfoxide or a cyclic sulfoxide represented by the formula I: ##STR1## wherein R is hydrogen or a lower alkyl group, in an amount sufficient to elicit a positive response by the ionization detector system.

Abstract translation: 一种通过挥发性有机磷酯向电离检测器系统模拟正响应的方法，其包括向电离检测器系统转移包含水蒸气和二（低级烷基）亚砜或由式I表示的环状亚砜的气流：其中R为氢或低级烷基，其量足以引起电离检测器系统的阳性反应。

公开(公告)号：USH346H

公开(公告)日：1987-10-06

申请号：US798268

申请日：1969-02-05

Applicant: Joseph Epstein ,  Harry O. Michel ,  Robert E. Plapinger ,  Joseph H. Fleisher ,  John J. Callahan ,  Bernard J. Jandorf

Inventor： Joseph Epstein ,  Harry O. Michel ,  Robert E. Plapinger ,  Joseph H. Fleisher ,  John J. Callahan ,  Bernard J. Jandorf

IPC: C07F9/40

CPC classification number: C07F9/4075

Abstract: The compounds of S-(2-dialkylaminoalkyl) alkyl phosphonothioic acids and hod of preparing said compounds possessing anticholinesterase activity comprising an aqueous solution which comprises dialkylaminoalkyl chloride salts which are converted to their corresponding dialkylmonoalkyl ammonium ions and alkylphosphonothioic acids forming a reaction mixture. The latter mixture is placed on a cation exchange resin with subsequent addition of water as an eluting agent giving rise to fractions containing the desired compounds.

公开(公告)号：US08284191B1

公开(公告)日：2012-10-09

申请号：US12418292

申请日：2009-04-03

Applicant: Joseph Epstein

Inventor： Joseph Epstein

IPC: G06T15/00

CPC classification number: G06T19/00 ,  G06T2219/2012 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/0022 ,  H04L1/20

Abstract: The invention provides techniques, including methods and systems, capable of displaying wireless network information regarding various wireless parameters in a three-dimensional (3D) virtual reality environment. The methods and systems provide graphical information to permit a network administrator to view and alter the wireless network virtually at one or more remote locations without being physically present at the remote location.

Abstract translation: 本发明提供了能够在三维（3D）虚拟现实环境中显示关于各种无线参数的无线网络信息的技术，包括方法和系统。 方法和系统提供图形信息，以允许网络管理员在一个或多个远程位置上虚拟地查看和改变无线网络，而不会物理地存在于远程位置。

公开(公告)号：US20070082939A1

公开(公告)日：2007-04-12

申请号：US11492608

申请日：2006-07-24

Applicant: Arnold Lippa ,  Phil Skolnick ,  Anthony Basile ,  Zhengming Chen ,  Joseph Epstein

Inventor： Arnold Lippa ,  Phil Skolnick ,  Anthony Basile ,  Zhengming Chen ,  Joseph Epstein

IPC: A61K31/403

CPC classification number: A61K31/403

Abstract: The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.

Abstract translation: 本发明提供了使用1-芳基-3-氮杂双环[3.1.0]己烷治疗与神经性疾病相关的症状的新颖的组合物和方法，所述神经性疾病例如痛觉过敏，异常性疼痛和副症状。 本发明还涉及1-芳基-3-氮杂双环[3.1.0]己烷在用于治疗哺乳动物神经病症和相关症状的药物组合物和方法中的用途。 根据本发明治疗的患者包括患有糖尿病性神经病，疱疹后神经痛，三叉神经痛，慢性下背痛，坐骨神经痛，特发性和创伤后神经病变，HIV相关神经性疼痛等许多其他神经病变和相关的患者 症状

公开(公告)号：US4108746A

公开(公告)日：1978-08-22

申请号：US831564

申请日：1977-09-08

Applicant: Theodore Mill ,  Constance W. Gould ,  Joseph Epstein ,  Leon J. Schiff

Inventor： Theodore Mill ,  Constance W. Gould ,  Joseph Epstein ,  Leon J. Schiff

IPC: B01J19/12 ,  C01B25/18 ,  C01B32/50 ,  C01G28/00 ,  B01J1/10

CPC classification number: C01B25/18 ,  B01J19/123 ,  C01B31/20 ,  C01G28/005 ,  C01P2002/86 ,  Y10S204/903

Abstract: A method for oxidatively degrading organophosphorous esters to phosphoric id, carbon dioxide and water through the use of a source of free hydroxy radicals, saturation of the resulting solution with oxygen and subsequent irradiation with UV radiation between 220 and 280 nm.

Abstract translation: 通过使用游离羟基自由基氧化降解有机磷酯至磷酸，二氧化碳和水的方法，所得溶液用氧饱和并随后用220-280nm的紫外线辐射照射。

公开(公告)号：US08472359B2

公开(公告)日：2013-06-25

申请号：US12964735

申请日：2010-12-09

Applicant: Vaduvur Bharghavan ,  Sung-Wook Han ,  Joseph Epstein ,  Berend Dunsbergen ,  Saravanan Balasubramanian

Inventor： Vaduvur Bharghavan ,  Sung-Wook Han ,  Joseph Epstein ,  Berend Dunsbergen ,  Saravanan Balasubramanian

IPC: H04B7/00 ,  H04W4/00 ,  H04L12/28

CPC classification number: H04W36/18 ,  H04W8/087 ,  H04W8/26 ,  H04W28/08 ,  H04W36/38 ,  H04W76/11 ,  H04W88/08

Abstract: AP's associated with a communication network and any wireless devices desiring contact, operated according to a protocol in which each wireless device selects AP's with which to communicate. A system coordinator causes the AP's to operate so as to guide each wireless device to an AP selected by the system coordinator. This has the effect that, notwithstanding that the protocol involves having the wireless device make the selection of AP, functionally, the AP's make the selection for it. In a 1st technique, multiple AP's share an identifier, with the system coordinator directing one particular AP to respond to the wireless device, thus appearing to wireless devices as a “personal cell”. In a 2nd technique, AP's each maintain identifiers substantially unique to each wireless device, with the system coordinator directing only one particular AP to maintain any particular wireless device's identifier, thus appearing to wireless devices as a “personal AP”.

Abstract translation: 与通信网络相关联的AP以及期望接触的任何无线设备，根据其中每个无线设备选择与之进行通信的AP的协议来操作。 系统协调器使AP操作，以便将每个无线设备引导到由系统协调器选择的AP。 这具有这样的效果，尽管协议涉及使无线设备进行AP的选择，但在功能上，AP对其进行选择。 在第一种技术中，多个AP共享标识符，系统协调器指示一个特定的AP对无线设备做出响应，从而将无线设备看作“个人小区”。 在第二种技术中，AP每个保持对每个无线设备基本唯一的标识符，系统协调器仅指示一个特定的AP来维护任何特定的无线设备的标识符，从而将无线设备看作“个人AP”。

公开(公告)号：US20080096733A1

公开(公告)日：2008-04-24

申请号：US11874005

申请日：2007-10-17

Applicant: Joseph Epstein

Inventor： Joseph Epstein

IPC: A63B69/34

CPC classification number: A63B69/201 ,  A63B2210/50 ,  A63B2244/102

Abstract: A liquid-fillable heavy training bag includes a cylindrical flexible outer shell having top and bottom walls to form a generally closed cylindrical inner surface. Suitable support is provided for suspending the cylindrical outer shell from an upper support member, such as a ceiling. A generally cylindrical liquid-impermeable flexible liner is provided within the outer shell for receiving and containing a liquid medium such as water. The liner is configured and dimensioned to generally conform to the shape of the inner surface of the outer shell when the liner is fully expanded, such as when filled with water. An intermediate layer is provided made of compressible material and arranged between and contacting the outer shell and the liner when the liner is filled with liquid. The intermediate layer forms a cushion for absorbing external impacts to the outer shell and absorbs and attenuates shock waves imparted to the liquid medium within the liner to protect the liner and better simulate the feel of a conventional, non-liquid filled heavy bag.

Abstract translation: 可充液的重型训练袋包括具有顶壁和底壁的圆柱形柔性外壳，以形成大致封闭的圆柱形内表面。 提供合适的支撑件用于将圆柱形外壳从诸如天花板的上支撑构件悬挂。 在外壳内设置一个大体圆柱形的液体不可渗透的柔性衬垫，用于接收和容纳诸如水的液体介质。 当衬垫完全膨胀时，例如当充满水时，衬套的构造和尺寸被设计成大致符合外壳的内表面的形状。 中间层由可压缩材料制成，并且当衬垫充满液体时，设置在外壳和衬套之间并与外套接触。 中间层形成用于吸收对外壳的外部冲击的衬垫，并吸收和减弱衬垫内的液体介质的冲击波，以保护衬垫并更好地模拟传统的非液体填充的重袋的感觉。

公开(公告)号：US07127712B1

公开(公告)日：2006-10-24

申请号：US10073669

申请日：2002-02-11

Applicant: Kenton E. Noble ,  Richard J. Lotero ,  Subash Chadalavada ,  William Greene ,  Keith Swartz ,  Joseph H. Kent ,  Joseph Epstein

Inventor： Kenton E. Noble ,  Richard J. Lotero ,  Subash Chadalavada ,  William Greene ,  Keith Swartz ,  Joseph H. Kent ,  Joseph Epstein

IPC: G06F9/44

CPC classification number: G06F8/65

Abstract: A system and method for providing a code release infrastructure with granular code patching is described. Code patches, each including at least one resource unit are provided. Each resource unit includes metadata and file components. Code libraries, each including at least one resource unit, are patched. The metadata for each resource unit in the code patches is compared to the metadata for each such corresponding resource unit in the code libraries. Each resource unit in the code patches is merged into the code libraries for each such corresponding resource unit that is out-of-date as defined by merge rules. Archive files, as defined by archive file definitions, are created or updated using the resource units from the code libraries, or, optionally, are deleted. The archive files are digitally signed also as required. The system and method enables source and derived code and third party code to be patched granularly.

Abstract translation: 描述了一种用于提供具有粒度代码补丁的代码释放基础设施的系统和方法。 提供了每个包括至少一个资源单元的代码补丁。 每个资源单元包括元数据和文件组件。 每个包含至少一个资源单元的代码库被修补。 代码块中每个资源单元的元数据与代码库中每个这样的相应资源单元的元数据进行比较。 代码补丁中的每个资源单元被合并到代码库中，用于每个由合并规则定义的过时的相应资源单元。 使用归档文件定义定义的归档文件将使用代码库中的资源单元创建或更新，或者，可选地，被删除。 归档文件也按照需要进行数字签名。 系统和方法使得源代码和派生代码和第三方代码能够被精细地修补。

公开(公告)号：US20050245517A1

公开(公告)日：2005-11-03

申请号：US11118111

申请日：2005-04-29

Applicant: Phil Skolnick ,  Joseph Epstein

Inventor： Phil Skolnick ,  Joseph Epstein

IPC: A61K31/519 ,  A61K31/5377 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides novel 2-pyridinyl[7(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones with at least one substituent on both the 2- and 4-pyridinyl ring having the chemical structure of formula I: The invention further provides compositions and methods employing the novel 2-pyridinyl[7-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones of formula I to modulate GABA and GABAA receptor physiology to elicit therapeutic responses in mammalian subjects to alleviate neurological or psychiatric disorders, including stroke, head trauma, epilepsy, pain, migraine, mood disorders, anxiety, post traumatic stress disorder, obsessive compulsive disorders, mania, bipolar disorders, schizophrenia, seizures, convulsions, tinnitus, neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease, Huntington's chorea, depression, bipolar disorders, mania, trigeminal and other neuralgia, neuropathic pain, hypertension, cerebral ischemia, cardiac arrhythmia, myotonia, substance abuse, myoclonus, essential tremor, dyskinesia and other movement disorders, neonatal cerebral hemorrhage, and spasticity, as well as other psychiatric and neurological disorders mediated by GABA and/or GABAA receptors.

Abstract translation: 本发明提供了具有至少一个取代基的2-吡啶基[7（吡啶-4-基）吡唑并[1,5-a]嘧啶-3-基]甲酮，其具有化学 式I的结构：本发明还提供了使用式I的新颖2-吡啶基[7-（吡啶-4-基）吡唑并[1,5-a]嘧啶-3-基]甲酮调节GABA的组合物和方法，以及 受体生理学在哺乳动物受试者中引发治疗反应以减轻神经或精神疾病，包括中风，头部创伤，癫痫，疼痛，偏头痛，情绪障碍，焦虑，创伤后应激障碍，强迫症 ，躁狂症，双相性精神障碍，精神分裂症，惊厥，抽搐，耳鸣，包括阿尔茨海默氏病，肌萎缩性侧索硬化和帕金森病，亨廷顿氏舞蹈病，抑郁症，双相情感障碍，躁狂症，三叉神经痛和其他神经痛，神经性疼痛，高血压，脑部神经退行性疾病 局部缺血，心律失常，肌强直，物质滥用，肌阵挛，原发性震颤，运动障碍和其他运动障碍，新生儿脑出血和痉挛状态，以及由GABA和/或GABA介导的其他精神和神经障碍。 SUB>受体。

公开(公告)号：US08787309B1

公开(公告)日：2014-07-22

申请号：US12913584

申请日：2010-10-27

Applicant: Vaduvur Bharghavan ,  Sung-Wook Han ,  Joseph Epstein ,  Berend Dunsbergen ,  Saravanan Balasubramanian

Inventor： Vaduvur Bharghavan ,  Sung-Wook Han ,  Joseph Epstein ,  Berend Dunsbergen ,  Saravanan Balasubramanian

IPC: H04W4/00

CPC classification number: H04W36/18 ,  H04W8/02 ,  H04W8/26 ,  H04W28/0226 ,  H04W28/08 ,  H04W60/00 ,  H04W84/105

Abstract: AP's associated with a communication network and any wireless devices desiring contact, operated according to a protocol in which each wireless device selects AP's with which to communicate. A system coordinator causes the AP's to operate so as to guide each wireless device to an AP selected by the system coordinator. This has the effect that, notwithstanding that the protocol involves having the wireless device make the selection of AP, functionally, the AP's make the selection for it. In a 1st technique, multiple AP's share an identifier, with the system coordinator directing one particular AP to respond to the wireless device, thus appearing to wireless devices as a “personal cell”. In a 2nd technique, AP's each maintain identifiers substantially unique to each wireless device, with the system coordinator directing only one particular AP to maintain any particular wireless device's identifier, thus appearing to wireless devices as a “personal AP”.

Abstract translation: 与通信网络相关联的AP以及期望接触的任何无线设备，根据其中每个无线设备选择与之进行通信的AP的协议来操作。 系统协调器使AP操作，以便将每个无线设备引导到由系统协调器选择的AP。 这具有这样的效果，尽管协议涉及使无线设备进行AP的选择，但在功能上，AP对其进行选择。 在第一种技术中，多个AP共享标识符，系统协调器指示一个特定的AP对无线设备做出响应，从而将无线设备看作“个人小区”。 在第二种技术中，AP每个保持对每个无线设备基本唯一的标识符，系统协调器仅指示一个特定的AP来维护任何特定的无线设备的标识符，从而将无线设备看作“个人AP”。