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公开(公告)号：US06696465B2
公开(公告)日：2004-02-24
申请号：US10322262
申请日：2002-12-17
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Byron A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Byron A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06720334B2
公开(公告)日：2004-04-13
申请号：US10358017
申请日：2003-02-04
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US06720333B2
公开(公告)日：2004-04-13
申请号：US10357995
申请日：2003-02-04
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06545017B1
公开(公告)日：2003-04-08
申请号：US10165453
申请日：2002-06-07
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06545016B1
公开(公告)日：2003-04-08
申请号：US10165229
申请日：2002-06-07
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06525064B1
公开(公告)日：2003-02-25
申请号：US10165002
申请日：2002-06-07
申请人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
发明人： Joseph F. Dellaria , Chad A. Haraldson , Philip D. Heppner , Kyle J. Lindstrom , Bryon A. Merrill
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US07897597B2
公开(公告)日：2011-03-01
申请号：US10595103
申请日：2004-08-27
申请人： Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
发明人： Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号：US08871782B2
公开(公告)日：2014-10-28
申请号：US10595230
申请日：2004-10-01
申请人： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah C. Johannessen
发明人： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah C. Johannessen
IPC分类号： A61K31/437 , C07D471/06 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
摘要： Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
摘要翻译： 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。
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公开(公告)号：US08263594B2
公开(公告)日：2012-09-11
申请号：US13008453
申请日：2011-01-18
申请人： Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Philip D. Heppner , Shri Niwas , Matthew R. Radmer
发明人： Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Philip D. Heppner , Shri Niwas , Matthew R. Radmer
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/497 , C07D471/04 , C07D413/14 , A61P31/12 , A61P35/00
CPC分类号： C07D471/04
摘要： Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 含有芳香氧基或芳基亚烷氧基取代基的6,7,8或9位的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US06720422B2
公开(公告)日：2004-04-13
申请号：US10357733
申请日：2003-02-04
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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