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公开(公告)号：US20120035209A1
公开(公告)日：2012-02-09
申请号：US13277619
申请日：2011-10-20
IPC分类号： A61K31/437 , A61P35/00 , A61P31/12 , C07D471/04
CPC分类号： C07D471/04
摘要： Hydroxy substituted 1H-imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 在2-位羟基取代的1H-咪唑并[4,5-c]吡啶-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和这些化合物的使用方法如 公开了用于在动物中诱导细胞因子生物合成和用于治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。
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公开(公告)号：US07939526B2
公开(公告)日：2011-05-10
申请号：US10596117
申请日：2004-12-03
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 咪唑环化合物（例如，咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和6,7,8,9-四氢咪唑并萘啶）与1-位硫醚基，亚磺酰基或磺酰基醚取代基 公开了含有化合物的药物组合物，中间体，制备该化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US20100152230A1
公开(公告)日：2010-06-17
申请号：US12065490
申请日：2006-09-01
IPC分类号： A61K31/437 , C07D471/04 , A61P31/12 , A61P35/00
CPC分类号： C07D471/04
摘要： Hydroxy substituted 1H-imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 在2-位羟基取代的1H-咪唑并[4,5-c]吡啶-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和这些化合物的使用方法如 公开了用于在动物中诱导细胞因子生物合成和用于治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。
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4.发明授权Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines 有权酰胺取代的咪唑并吡啶，咪唑并喹啉和咪唑并吡啶公开(公告)号：US08697873B2
公开(公告)日：2014-04-15
申请号：US10599159
申请日：2005-03-24
申请人： Larry R. Krepski , Joseph F. Dellaria, Jr. , Daniel E. Duffy , David T. Amos , Bernhard M. Zimmermann , William H. Moser
发明人： Larry R. Krepski , Joseph F. Dellaria, Jr. , Daniel E. Duffy , David T. Amos , Bernhard M. Zimmermann , William H. Moser
IPC分类号： C07D401/02 , A61K31/437
CPC分类号： C07D471/04 , C07D413/14 , C07D471/02 , C07D471/12 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US07544697B2
公开(公告)日：2009-06-09
申请号：US11097715
申请日：2005-04-01
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 吡唑并吡啶-4-胺，吡唑并喹啉-4-胺，吡唑啉酮-4-胺和6,7,8,9-四氢吡唑并喹啉-4-胺，含有化合物，中间体，制备方法和使用方法的药物组合物 这些化合物作为用于在动物中诱导或抑制细胞因子生物合成以及治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。
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公开(公告)号：US20120121651A1
公开(公告)日：2012-05-17
申请号：US13359213
申请日：2012-01-26
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： A61K31/4745 , C07D471/14 , A61K31/4375 , A61K31/496 , A61P37/02 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/635 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , C07D401/14 , C07D471/14 , C07D495/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 吡唑并吡啶-4-胺，吡唑啉-4-胺，吡唑啉-4-基胺，6,7,8,9-四氢吡唑并喹啉-4-胺及其前药，含有这些化合物的药物组合物，中间体，制备方法和方法 这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US08168802B2
公开(公告)日：2012-05-01
申请号：US11887525
申请日：2006-03-31
申请人： David S. Hays , Sonja S. Mackey , William H. Moser , Doris D. Stoermer , Matthew R. Radmer , Shri Niwas
发明人： David S. Hays , Sonja S. Mackey , William H. Moser , Doris D. Stoermer , Matthew R. Radmer , Shri Niwas
IPC分类号： C07D233/70 , C07D233/66 , C07D471/00
CPC分类号： C07D471/04 , C07D233/90 , C07D471/14
摘要： Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:
摘要翻译： 可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：
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公开(公告)号：US09145410B2
公开(公告)日：2015-09-29
申请号：US13359213
申请日：2012-01-26
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： C07D471/04 , C07D471/14 , C07D401/14 , C07D495/14
CPC分类号： C07D471/04 , C07D401/14 , C07D471/14 , C07D495/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 吡唑并吡啶-4-胺，吡唑啉-4-胺，吡唑啉-4-基胺，6,7,8,9-四氢吡唑并喹啉-4-胺及其前药，含有这些化合物的药物组合物，中间体，制备方法和方法 这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US07879849B2
公开(公告)日：2011-02-01
申请号：US12480471
申请日：2009-06-08
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： A61K31/5377 , A61K31/437 , A61P37/04 , C07D413/14 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 吡唑并吡啶-4-胺，吡唑并喹啉-4-胺，吡唑啉酮-4-胺和6,7,8,9-四氢吡唑并喹啉-4-胺，含有化合物，中间体，制备方法和使用方法的药物组合物 这些化合物作为用于在动物中诱导或抑制细胞因子生物合成以及治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。
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公开(公告)号：US07125890B2
公开(公告)日：2006-10-24
申请号：US10916125
申请日：2004-08-11
申请人： Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Daniel E. Duffy , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer , Bernhard M. Zimmermann
发明人： Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Daniel E. Duffy , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer , Bernhard M. Zimmermann
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译： 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。
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