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公开(公告)号:US09776963B2
公开(公告)日:2017-10-03
申请号:US13128549
申请日:2009-11-10
申请人: Joseph G. Sodroski , Navid Madani , Arne Schön , Judith M. LaLonde , Joel R. Courter , Takahiro Soeta , Danny Ng , Ernesto Freire , Amos B. Smith, III , Amy M. Princiotto , Matthew Le-Khac , Wayne A. Hendrickson
发明人: Joseph G. Sodroski , Navid Madani , Arne Schön , Judith M. LaLonde , Joel R. Courter , Takahiro Soeta , Danny Ng , Ernesto Freire , Amos B. Smith, III , Amy M. Princiotto , Matthew Le-Khac , Wayne A. Hendrickson
IPC分类号: A61K31/397 , C07D211/58 , C07D205/04 , C07D207/09 , C07D207/16 , C07D207/22 , C07D211/26 , C07D211/44 , C07D211/56 , C07D217/14 , C07D223/04 , C07D231/56 , C07D233/64 , C07D235/02 , C07D235/14 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/90 , C07D249/08 , C07D265/36 , C07D295/13 , C07D307/52 , C07D317/28 , C07D333/20 , C07D333/48 , C07D401/04 , C07D401/06 , C07D405/06 , C07D409/14 , C07D455/02 , C07D471/08 , C07D473/18 , C07D487/04 , C07D495/04
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/16 , C07D207/22 , C07D211/26 , C07D211/44 , C07D211/56 , C07D217/14 , C07D223/04 , C07D231/56 , C07D233/64 , C07D235/02 , C07D235/14 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/90 , C07D249/08 , C07D265/36 , C07D295/13 , C07D307/52 , C07D317/28 , C07D333/20 , C07D333/48 , C07D401/04 , C07D401/06 , C07D405/06 , C07D409/14 , C07D455/02 , C07D471/08 , C07D473/18 , C07D487/04 , C07D495/04
摘要: The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted; (ii) OH, ORc, NH2, NHRc, NRcRc, SH, S(O)mRc; or (iii) RA and RB together form C(O); W is absent, C(O), C(O)O, C(O)NRcRc, O, S(O)m, or NRcRc; Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRXRY; wherein Rx and Ry are each independently H, alkyl or aryl; X1 is selected from the group consisting of halogen, methyl, and hydroxyl; X2 is a halogen; each Rc is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted; m is O, 1, or 2; and n is 1, 2, 3, 4, 5, or 6; and pharmaceutically acceptable salts thereof.
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公开(公告)号:US20120122834A1
公开(公告)日:2012-05-17
申请号:US13128549
申请日:2009-11-10
申请人: Joseph Sodroski , Navid Madani , Arne Schon , Judith M. La Londe , Joel R. Courter , Takahiro Soeta , Danny Ng , Ernesto Freire , Amos B. Smith, III
发明人: Joseph Sodroski , Navid Madani , Arne Schon , Judith M. La Londe , Joel R. Courter , Takahiro Soeta , Danny Ng , Ernesto Freire , Amos B. Smith, III
IPC分类号: A61K31/397
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/16 , C07D207/22 , C07D211/26 , C07D211/44 , C07D211/56 , C07D217/14 , C07D223/04 , C07D231/56 , C07D233/64 , C07D235/02 , C07D235/14 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/90 , C07D249/08 , C07D265/36 , C07D295/13 , C07D307/52 , C07D317/28 , C07D333/20 , C07D333/48 , C07D401/04 , C07D401/06 , C07D405/06 , C07D409/14 , C07D455/02 , C07D471/08 , C07D473/18 , C07D487/04 , C07D495/04
摘要: The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted; (ii) OH, ORc, NH2, NHL, NRcRc, SH, S(O)mRc; or (iii) RA and RB together form C(O); W is absent, C(O), C(O)O, C(O)NRcRc, O, S(O)m, or NRcRc; Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRXRY; wherein Rx and Ry are each independently H, alkyl or aryl; X1 is selected from the group consisting of halogen, methyl, and hydroxyl; X2 is a halogen; each Rc is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted; m is O, 1, or 2; and n is 1, 2, 3, 4, 5, or 6; and pharmaceutically acceptable salts thereof.
摘要翻译: 本发明提供式I化合物:其中Z不存在或(CRARB)nW; 每个RA和RB独立地为(i)H,烷基,烯基,炔基,环烷基,杂环烷基,芳基,杂芳基,芳烷基,杂芳烷基,卤代烷基,其各自可以任选被取代; (ii)OH,ORc,NH 2,NHL,NRcRc,SH,S(O)mRc; 或(iii)RA和RB一起形成C(O); W不存在,C(O),C(O)O,C(O)NRcRc,O,S(O)m或NRcRc; Y是任选取代的杂环,任选取代的杂芳基,任选取代的环烷基,任选取代的芳基或NRXRY; 其中Rx和Ry各自独立地为H,烷基或芳基; X1选自卤素,甲基和羟基; X2是卤素; 每个R c独立地为烷基,环烷基,杂环烷基,芳基,杂芳基,芳烷基或杂芳烷基,其各自可以任选被取代; m为O,1或2; n为1,2,3,4,5或6; 及其药学上可接受的盐。
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