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公开(公告)号：US6120538A
公开(公告)日：2000-09-19
申请号：US74196
申请日：1998-05-07
CPC分类号： A61F2/1635 , A61F2/1613 , A61F9/08 , G02B3/14 , A61N1/36046
摘要： Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.
摘要翻译： 动态功能性眼内假体。 假体包括可植入的眼内透镜和安装在透镜上的微电子部件。 一个实施例是用于调节可植入透镜的焦距的可变焦距可植入眼内透镜系统。 在一个实施例中，微型电动机改变围绕可变形透镜的周边部分的带的张力，改变其形状以改变其焦距。 另一个实施方案是人造眼内透镜，其用作形成假体的一部分的微电子部件的保持基底，以刺激眼睛的神经元件以恢复对视网膜疾病失明的患者的视力。
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公开(公告)号：US5575813A
公开(公告)日：1996-11-19
申请号：US394719
申请日：1995-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5476494A
公开(公告)日：1995-12-19
申请号：US234725
申请日：1994-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5411540A
公开(公告)日：1995-05-02
申请号：US72320
申请日：1993-06-03
CPC分类号： A61N1/0543 , A61N1/0551
摘要： The invention provides a method for preferentially stimulating neural somas over neural axons located around the somas but not integral with the somas. In the invention, a positive electrical pulse is applied to a region of neural tissue consisting of one or more neural somas to be stimulated and neural axons, and due to the physiology of the somas, they are preferentially stimulated by the electrical pulse over the neural axons not integral with the somas to be stimulated. The preferential soma stimulation provided by the invention achieves the advantage of locally focusing external stimulation such that it may be directed to particular soma locations for indicating location-dependent sensory information. Thus the pulse scheme of the invention may be employed in prosthetic applications directed to, for example, the retinal ganglia neural tissue.
摘要翻译： 本发明提供了一种用于优先地刺激位于躯体周围但与体细胞不整合的神经轴突的神经细胞的方法。 在本发明中，正电脉冲被施加到由待刺激的一个或多个神经细胞组成的神经组织区域和神经轴突，并且由于躯体的生理学，它们优先地被神经元上的电脉冲刺激 轴突不与要刺激的躯体成分。 本发明提供的优选的瘤细胞刺激实现了局部聚焦外部刺激的优点，使得其可以被引导到特定的肿瘤位置以指示位置相关的感觉信息。 因此，本发明的脉冲方案可用于针对例如视网膜神经节神经组织的假体应用。
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公开(公告)号：US5800530A
公开(公告)日：1998-09-01
申请号：US516711
申请日：1995-08-18
申请人： Joseph Rizzo, III
发明人： Joseph Rizzo, III
CPC分类号： A61F2/1635 , A61F2/1613 , A61F9/08 , G02B3/14 , A61N1/36046
摘要： Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.
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公开(公告)号：US5554187A
公开(公告)日：1996-09-10
申请号：US517157
申请日：1995-08-18
申请人： Joseph Rizzo, III
发明人： Joseph Rizzo, III
CPC分类号： A61F2/16 , A61F2/1613 , A61F9/0017 , A61K9/0051 , A61L27/34 , A61L27/54 , A61F2002/009 , A61F2250/0067 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/41 , A61L2300/602
摘要： Medication dispensing intra-ocular lens system for implantation into an eye. An implantable intra-ocular lens includes a carrier medium disposed on a surface of the lens. A biologically active material is embedded in the carrier medium for controlled release into the eye. Contemplated biologically active materials include antibiotics, anti-inflammatory agents and cell growth inhibitors. The controlled release of biologically active materials within the eye is more effective than conventional topical applications of the same substances.
摘要翻译： 药物分配眼内透镜系统用于植入眼睛。 可植入眼内透镜包括设置在透镜表面上的载体介质。 将生物活性物质嵌入载体介质中以控制释放到眼睛中。 考虑的生物活性材料包括抗生素，抗炎剂和细胞生长抑制剂。 生物活性物质在眼内的受控释放比常规局部应用的相同物质更有效。
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公开(公告)号：US5597381A
公开(公告)日：1997-01-28
申请号：US72321
申请日：1993-06-03
申请人： Joseph Rizzo, III
发明人： Joseph Rizzo, III
CPC分类号： A61F2/14 , A61F9/00736 , A61F9/00781
摘要： A method for epi-retinal implantation of an object into a subject is disclosed. The method includes rendering the normally transparent cortical vitreous visible and separating at least a portion of a cortical vitreous of the subject away from an adherent retinal surface to form an epi-retinal space between the retina and the separated cortical vitreous material. An object to be implanted may be introduced into the epi-retinal space and the object engaged with a surface of the retina. In preferred embodiments, the object may then be adhered to the surface of the retina. A method for implantation of a neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated is also described. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 公开了将物体视网膜植入物体的方法。 该方法包括使正常透明的皮质玻璃体可见并将受试者的皮质玻璃体的至少一部分远离粘附的视网膜表面以在视网膜和分离的皮层玻璃体材料之间形成视网膜间隙。 可以将待植入的物体引入视网膜内空间，并且物体与视网膜的表面接合。 在优选实施例中，物体可以然后粘附到视网膜的表面。 还描述了用于植入用于与神经组织接触的神经接触结构的方法，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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