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公开(公告)号：US5575813A
公开(公告)日：1996-11-19
申请号：US394719
申请日：1995-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5476494A
公开(公告)日：1995-12-19
申请号：US234725
申请日：1994-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5411540A
公开(公告)日：1995-05-02
申请号：US72320
申请日：1993-06-03
CPC分类号： A61N1/0543 , A61N1/0551
摘要： The invention provides a method for preferentially stimulating neural somas over neural axons located around the somas but not integral with the somas. In the invention, a positive electrical pulse is applied to a region of neural tissue consisting of one or more neural somas to be stimulated and neural axons, and due to the physiology of the somas, they are preferentially stimulated by the electrical pulse over the neural axons not integral with the somas to be stimulated. The preferential soma stimulation provided by the invention achieves the advantage of locally focusing external stimulation such that it may be directed to particular soma locations for indicating location-dependent sensory information. Thus the pulse scheme of the invention may be employed in prosthetic applications directed to, for example, the retinal ganglia neural tissue.
摘要翻译： 本发明提供了一种用于优先地刺激位于躯体周围但与体细胞不整合的神经轴突的神经细胞的方法。 在本发明中，正电脉冲被施加到由待刺激的一个或多个神经细胞组成的神经组织区域和神经轴突，并且由于躯体的生理学，它们优先地被神经元上的电脉冲刺激 轴突不与要刺激的躯体成分。 本发明提供的优选的瘤细胞刺激实现了局部聚焦外部刺激的优点，使得其可以被引导到特定的肿瘤位置以指示位置相关的感觉信息。 因此，本发明的脉冲方案可用于针对例如视网膜神经节神经组织的假体应用。
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公开(公告)号：US06643552B2
公开(公告)日：2003-11-04
申请号：US10158510
申请日：2002-05-30
申请人： David J. Edell , Brian Farrell
发明人： David J. Edell , Brian Farrell
IPC分类号： A61N105
CPC分类号： A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/0553 , A61N1/0558
摘要： An implantable medical device (IMD) is disclosed that is formed on a substrate composed of liquid crystal polymer (LCP). In one embodiment, the IMD can be an interconnection module for interconnecting an electrode array to an equipment module. The interconnecting module includes conductors disposed on the LCP substrate and coupled to the electrode array, and wherein the conductors are encapsulated using a silicone or LCP encapsulant. In another embodiment, the IMD is an electrode array and interconnect module disposed on an integral LCP substrate. An equipment module can be coupled to the interconnect module. Alternatively, a hybrid electronic circuit can be coupled to the interconnect module for signal processing and conditioning signals received from the electrode array or for providing stimulus signals to the electrode array. In this embodiment, all of the conductors and at least a portion of the electrodes in the electrode array are encapsulated using a silicone or LCP encapsulant. In another embodiment, the IMD is an electrode array, an interconnecting module, and a hybrid circuit that are disposed on an LCP substrate. The interconnecting module is used to provide signal paths to and from the electrodes in the electrode array to the hybrid circuit. In this embodiment, all of the conductors, the hybrid electronic circuit and at least a portion of the electrodes in the electrode array are encapsulated using a silicone or LCP encapsulant.
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公开(公告)号：US20090201172A1
公开(公告)日：2009-08-13
申请号：US11920580
申请日：2006-05-16
申请人： David J. Edell
发明人： David J. Edell
CPC分类号： A61B5/0002 , A61B5/0488 , A61B2560/0209 , A61B2562/02
摘要： A low power miniaturized telemeter (25, 40-42) provides data from a monitored subject at internal or external locations. A charge integration and pulse stream encoding (30) in the telemeter (25, 40-42) contributes to reduced power consumption. A transmitter (29) in the telemeter (25, 40-42) may be omnidirectional to permit operation without physical obstruction or limitations to movement. A receiver (22) collects transmitted information and may have an adaptive threshold pulse detector to permit further reductions in power usage. The telemeter (25, 40-42) can multiplex monitored parameters on a time division basis to permit trans-mission of multiple data channels. Individual telemeters may have unique transmission frequencies to permit multiple telemeters to be used concurrently without interference. A self-contained power source in the telemeter (25, 40-42) permits long term operation at low power without the need of replacement. The telemeter (25, 40-42) can be packaged to accommodate a number of applications, such as by permitting adjustable density.
摘要翻译： 低功耗小型化遥测仪（25,40-42）可在内部或外部位置提供受监控对象的数据。 遥测仪（25,40-42）中的电荷积分和脉冲流编码（30）有助于降低功耗。 遥测仪（25,40-42）中的发射器（29）可以是全向的，以允许在没有物理障碍或运动限制的情况下进行操作。 接收器（22）收集所发送的信息，并且可以具有自适应阈值脉冲检测器以允许进一步减少功率使用。 遥测仪（25,40-42）可以在时间基础上复用监视的参数，以允许多个数据通道的传输。 单个电报可能具有唯一的传输频率，以允许同时使用多个遥测器而不受干扰。 遥测仪中的独立电源（25,40-42）允许在低功率下长期运行，无需更换。 遥测仪（25,40-42）可以包装以适应许多应用，例如通过允许可调节的密度。
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公开(公告)号：US5888591A
公开(公告)日：1999-03-30
申请号：US643721
申请日：1996-05-06
IPC分类号： B05D7/24 , C08F2/46 , C23C16/46 , C23C16/515 , H01L21/312 , H01L23/532
CPC分类号： C23C16/463 , B05D1/62 , C23C16/46 , C23C16/515 , H01L21/3127 , H01L23/5329 , H01L2924/0002 , Y10T428/21 , Y10T428/2933 , Y10T428/2938 , Y10T428/3154 , Y10T428/31544
摘要： Provided are methods for forming a fluorocarbon polymer thin film on the surface of a structure. In one method, a monomer gas is exposed to a source of heat having a temperature sufficient to pyrolyze the monomer gas and produce a source of reactive CF.sub.2 species in the vicinity of the structure surface. The structure surface is maintained substantially at a temperature lower than that of the heat source to induce deposition and polymerization of the CF.sub.2 species on the structure surface. In another method for forming a fluorocarbon polymer thin film, the structure is exposed to a plasma environment in which a monomer gas is ionized to produce reactive CF.sub.2 species. The plasma environment is produced by application to the monomer gas of plasma excitation power characterized by an excitation duty cycle having alternating intervals in which excitation power is applied and in which no excitation power is applied to the monomer gas. The monomer gas employed in the methods preferably includes hexafluoropropylene oxide. The monomer gas pyrolysis and plasma excitation methods can be carried out individually, sequentially, or simultaneously. Flexible fluorocarbon polymer thin films can thusly be produced on wires, twisted wires, neural probes, tubing, complex microstructures, substrates, microfabricated circuits, and other structures. The thin films have a compositional CF.sub.2 fraction of at least about 50%, a dielectric constant of less than about 1.95, and a crosslinking density of less than about 35%.
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公开(公告)号：US5116464A
公开(公告)日：1992-05-26
申请号：US624514
申请日：1990-12-07
IPC分类号： H01L21/306 , H01L21/308
CPC分类号： H01L21/3081 , H01L21/30608
摘要： An aqueous solution of cesium hydroxide serves as a highly selective anisotropic etch for semiconductor crystals including silicon. The cesium hydroxide also has a high etch selectivity for tantalum with respect to semiconductor crystals.
摘要翻译： 氢氧化铯的水溶液用作包括硅的半导体晶体的高选择性各向异性蚀刻。 相对于半导体晶体，氢氧化铯对于钽也具有高蚀刻选择性。
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公开(公告)号：US06680642B2
公开(公告)日：2004-01-20
申请号：US10154045
申请日：2002-05-23
申请人： David J. Edell , Sean V. Sexton , Ying-Ping Liu
发明人： David J. Edell , Sean V. Sexton , Ying-Ping Liu
IPC分类号： G05F110
CPC分类号： G05F1/10
摘要： A precision current source is disclosed that includes a voltage setting circuit that precisely sets the voltage across a range setting resistor to set the current flowing in a load resistance connected in series with the range setting resistor. The voltage setting circuit precisely sets the voltage across the range setting resistor as a function of an input reference voltage. The voltage setting circuit includes an instrumentation amplifier that determines the voltage across the range setting resistor and the difference between this voltage and the reference voltage is used drive a drive voltage amplifier. The drive voltage amplifier output adjusts to minimize the difference between the reference voltage and the voltage across the range setting resistor. Other embodiments include the use of a DC blocking capacitor to allow only AC coupling and various nulling. circuits to remove any charge buildup on a DC blocking capacitor.
摘要翻译： 公开了一种精密电流源，其包括电压设定电路，其精确地设定跨越范围设定电阻器的电压，以设定与与量程设定电阻器串联连接的负载电阻中流动的电流。 电压设置电路根据输入参考电压精确地设置范围设置电阻两端的电压。 电压设定电路包括一个仪表放大器，用于确定范围设定电阻器两端的电压，并且该电压与参考电压之差用于驱动驱动电压放大器。 驱动电压放大器输出调整为最小化参考电压和范围设置电阻两端的电压之间的差异。 其他实施例包括使用隔直流电容器仅允许AC耦合和各种零位。 电路去除直流阻塞电容器上的任何电荷积累。
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公开(公告)号：US6156435A
公开(公告)日：2000-12-05
申请号：US280377
申请日：1999-03-29
IPC分类号： B05D7/24 , C08F2/46 , C23C16/46 , C23C16/515 , H01L21/312 , H01L23/532 , B32B27/00
CPC分类号： C23C16/463 , B05D1/62 , C23C16/46 , C23C16/515 , H01L21/3127 , H01L23/5329 , H01L2924/0002 , Y10T428/21 , Y10T428/2933 , Y10T428/2938 , Y10T428/3154 , Y10T428/31544
摘要： Provided are methods for forming a fluorocarbon polymer thin film on the surface of a structure. In one method, a monomer gas is exposed to a source of heat having a temperature sufficient to pyrolyze the monomer gas and produce a source of reactive CF.sub.2 species in the vicinity of the structure surface. The structure surface is maintained substantially at a temperature lower than that of the heat source to induce deposition and polymerization of the CF.sub.2 species on the structure surface. In another method for forming a fluorocarbon polymer thin film, the structure is exposed to a plasma environment in which a monomer gas is ionized to produce reactive CF.sub.2 species. The plasma environment is produced by application to the monomer gas of plasma excitation power characterized by an excitation duty cycle having alternating intervals in which excitation power is applied and in which no excitation power is applied to the monomer gas. The monomer gas employed in the methods preferably includes hexafluoropropylene oxide. The monomer gas pyrolysis and plasma excitation methods can be carried out individually, sequentially, or simultaneously. Flexible fluorocarbon polymer thin films can thusly be produced on wires, twisted wires, neural probes, tubing, complex microstructures, substrates, microfabricated circuits, and other structures. The thin films have a compositional CF.sub.2 fraction of at least about 50%, a dielectric constant of less than about 1.95, and a crosslinking density of less than about 35%.
摘要翻译： 提供了在结构的表面上形成氟碳聚合物薄膜的方法。 在一种方法中，将单体气体暴露于具有足以热解单体气体并在结构表面附近产生反应性CF 2物质源的热源。 结构表面基本保持在比热源低的温度下，以引起CF2物质在结构表面上的沉积和聚合。 在形成氟碳聚合物薄膜的另一种方法中，该结构暴露于其中单体气体被离子化以产生反应性CF 2物质的等离子体环境中。 等离子体环境通过应用于等离子体激发功率的单体气体产生，其特征在于具有施加激发功率的交替间隔的激发占空比，并且其中没有激发功率施加到单体气体。 在该方法中使用的单体气体优选包括六氟环氧丙烷。 单体气体热解和等离子体激发方法可以单独，顺序或同时进行。 柔性氟碳聚合物薄膜因此可以在电线，绞线，神经探针，管道，复合微结构，基板，微结构电路和其他结构上生产。 薄膜具有至少约50％的组成CF 2分数，小于约1.95的介电常数和小于约35％的交联密度。
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公开(公告)号：US06153269A
公开(公告)日：2000-11-28
申请号：US280196
申请日：1999-03-29
IPC分类号： B05D7/24 , C08F2/46 , C23C16/46 , C23C16/515 , H01L21/312 , H01L23/532 , C08J7/18
CPC分类号： C23C16/463 , B05D1/62 , C23C16/46 , C23C16/515 , H01L21/3127 , H01L23/5329 , H01L2924/0002 , Y10T428/21 , Y10T428/2933 , Y10T428/2938 , Y10T428/3154 , Y10T428/31544
摘要： Provided are methods for forming a fluorocarbon polymer thin film on the surface of a structure. In one method, a monomer gas is exposed to a source of heat having a temperature sufficient to pyrolyze the monomer gas and produce a source of reactive CF.sub.2 species in the vicinity of the structure surface. The structure surface is maintained substantially at a temperature lower than that of the heat source to induce deposition and polymerization of the CF.sub.2 species on the structure surface. In another method for forming a fluorocarbon polymer thin film, the structure is exposed to a plasma environment in which a monomer gas is ionized to produce reactive CF.sub.2 species. The plasma environment is produced by application to the monomer gas of plasma excitation power characterized by an excitation duty cycle having alternating intervals in which excitation power is applied and in which no excitation power is applied to the monomer gas. The monomer gas employed in the methods preferably includes hexafluoropropylene oxide. The monomer gas pyrolysis and plasma excitation methods can be carried out individually, sequentially, or simultaneously. Flexible fluorocarbon polymer thin films can thusly be produced on wires, twisted wires, neural probes, tubing, complex microstructures, substrates, microfabricated circuits, and other structures. The thin films have a compositional CF.sub.2 fraction of at least about 50%, a dielectric constant of less than about 1.95, and a crosslinking density of less than about 35%.
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