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1.发明申请公开(公告)号：US20070198071A1
公开(公告)日：2007-08-23
申请号：US11359092
申请日：2006-02-22
申请人： Joseph Ting , Samuel Tolkoff , Timothy Robinson , Richard Wisdom
发明人： Joseph Ting , Samuel Tolkoff , Timothy Robinson , Richard Wisdom
CPC分类号： A61F7/00 , A61F7/007 , A61F7/10 , A61F2007/0056 , A61F2007/0075 , A61F2007/0076 , A61F2007/0086 , A61F2007/0087 , A61F2007/029
摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.
摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。
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2.发明申请公开(公告)号：US20130158636A1
公开(公告)日：2013-06-20
申请号：US13616497
申请日：2012-09-14
IPC分类号： A61F7/00
CPC分类号： A61F7/00 , A61F7/007 , A61F7/10 , A61F2007/0056 , A61F2007/0075 , A61F2007/0076 , A61F2007/0086 , A61F2007/0087 , A61F2007/029
摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.
摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。
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3.发明授权公开(公告)号：US07854754B2
公开(公告)日：2010-12-21
申请号：US11359092
申请日：2006-02-22
IPC分类号： A61F7/00
CPC分类号： A61F7/00 , A61F7/007 , A61F7/10 , A61F2007/0056 , A61F2007/0075 , A61F2007/0076 , A61F2007/0086 , A61F2007/0087 , A61F2007/029
摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.
摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。
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4.发明授权公开(公告)号：US08337539B2
公开(公告)日：2012-12-25
申请号：US12942852
申请日：2010-11-09
IPC分类号： A61F7/00
CPC分类号： A61F7/00 , A61F7/007 , A61F7/10 , A61F2007/0056 , A61F2007/0075 , A61F2007/0076 , A61F2007/0086 , A61F2007/0087 , A61F2007/029
摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.
摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。
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公开(公告)号：US20110066216A1
公开(公告)日：2011-03-17
申请号：US12942852
申请日：2010-11-09
IPC分类号： A61F7/00
CPC分类号： A61F7/00 , A61F7/007 , A61F7/10 , A61F2007/0056 , A61F2007/0075 , A61F2007/0076 , A61F2007/0086 , A61F2007/0087 , A61F2007/029
摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.
摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。
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公开(公告)号：US08876881B2
公开(公告)日：2014-11-04
申请号：US11876764
申请日：2007-10-22
申请人： Jeffery Sheldon , Richard Booth , Gary Boseck , Richard Wisdom , Ken Bueche , Bruce Dannecker
发明人： Jeffery Sheldon , Richard Booth , Gary Boseck , Richard Wisdom , Ken Bueche , Bruce Dannecker
CPC分类号： A61F2/966 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2/954 , A61F2/962 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665 , A61F2220/005 , B23K26/21 , B23K2101/32 , B23K2103/14 , D10B2509/06
摘要： Devices and methods for stent advancement, including methods for instructing another or others how to advance a stent into an anatomical structure or into a testing/demonstration synthetic structure, such as a polymer tube. The advancement may be achieved by at least two periods of stent engagement that drive a stent distally from a sheath separated by a period of non-engagement.
摘要翻译： 用于支架前进的装置和方法，包括用于指导另一个或其他如何将支架推进解剖结构或测试/示范合成结构（诸如聚合物管）的方法。 该进展可以通过至少两个支架接合周期来实现，其中支架从远离非鞘膜分离的护套向远侧驱动。
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7.发明申请Method for Producing Single Enantiomer Epoxides by the Adh Reduction of a-Leaving Group-Substituted Ketones and Cyclization 审中-公开通过减少取代的取代酮和环化生成单一对映异构体环氧化物的方法公开(公告)号：US20080206826A1
公开(公告)日：2008-08-28
申请号：US11917777
申请日：2006-06-07
申请人： Andreas Meudt , Richard Wisdom , Claudius Boehm
发明人： Andreas Meudt , Richard Wisdom , Claudius Boehm
IPC分类号： C12P17/02
CPC分类号： C07D301/26 , C07D303/08
摘要： The invention relates to a method for producing single enantiomer epoxides by reducing α-leaving group-substituted ketones with (R)- or (S)-selective alcohol dehydrogenases in the presence of a cofactor and optionally a suitable system for regenerating the oxidised cofactor, to produce the corresponding single enantiomer alcohols and subsequently, by means of cyclisation induced by a base, the corresponding single enantiomer epoxides (EQUATION 1) wherein LG may stand for F, Cl, Br, I, OSO2Ar, OSO2CH3, OSO2R or OP(O)OR2, and R1, R2 and R3, independently of one another, stand for hydrogen, a branched or unbranched, optionally substituted C1-C20-alkyl radical, symbolize an optionally randomly substituted C3-C1-10-cycloalkyl or alkenyl radical or a randomly substituted carbo- or heterocyclic aryl radical, or correspond to a radical from the group CO2R, CONR2, COSR, CS2R, C(NH)NR2, CN, CHaI3, ArO, ArS, RO, RS, CHO, OH, NHR, NR2, Cl, F, Br, I or SiR3.
摘要翻译： 本发明涉及通过在辅助因子和任选的用于再生氧化辅因子的合适系统的存在下，用（R） - 或（S） - 选择性醇脱氢酶还原α-离去基团取代的酮来生产单一对映异构体环氧化物的方法， 以产生相应的单一对映异构体醇，随后通过由碱诱导的环化，相应的单一对映异构体环氧化物（方程式1）其中LG可代表F，Cl，Br，I，OSO 2 Ar，OSO 2，CH 3，OSO 2 R或OP（O）OR 2，和R
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公开(公告)号：US08975396B2
公开(公告)日：2015-03-10
申请号：US13701580
申请日：2011-04-14
申请人： Richard Wisdom , Joerg Jung , Andreas Meudt
发明人： Richard Wisdom , Joerg Jung , Andreas Meudt
IPC分类号： C07D223/28
CPC分类号： C07D223/28 , C07B2200/07
摘要： The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.
摘要翻译： 本发明涉及一种酮底物的不对称转移氢化方法，以生产具有大于85％的ee的手性仲醇，其中使用含有钌或铑的富含对映体的手性催化剂与氢供体一起使用，其中 使用阴离子交换树脂作为碱。
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公开(公告)号：US20130123490A1
公开(公告)日：2013-05-16
申请号：US13701580
申请日：2011-04-14
申请人： Richard Wisdom , Joeng Jung , Andress Meudt
发明人： Richard Wisdom , Joeng Jung , Andress Meudt
IPC分类号： C07D223/28
CPC分类号： C07D223/28 , C07B2200/07
摘要： The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.
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公开(公告)号：US08598386B2
公开(公告)日：2013-12-03
申请号：US13274718
申请日：2011-10-17
申请人： Richard Wisdom , Joerg Jung , Andreas Meudt
发明人： Richard Wisdom , Joerg Jung , Andreas Meudt
IPC分类号： C07C231/02 , C07C231/12 , C07C231/14 , C07C269/06
CPC分类号： C07C231/12 , C07B2200/07 , C07C231/14 , C07C231/18 , C07C269/06 , C07C237/22 , C07C271/22
摘要： The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20° C.
摘要翻译： 本发明涉及通过（R）-2-乙酰氨基-2-N-苄基-3-羟基 - 丙酰胺的甲基化制备（R）-2-乙酰氨基-N-苄基-3-甲氧基丙酰胺（lacosamide）的方法 （V），其中甲基化在低于20℃的温度下进行。
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