公开(公告)号：US20110098805A1

公开(公告)日：2011-04-28

申请号：US12870567

申请日：2010-08-27

申请人： Joshua Dwork ,  Patrick E. Macaulay ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Richard Spork ,  Don Huy Tran ,  Nathan B. Wiemeyer

发明人： Joshua Dwork ,  Patrick E. Macaulay ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Richard Spork ,  Don Huy Tran ,  Nathan B. Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412

摘要： Delivery devices and methods for percutaneously delivering a prosthetic valve to the heart of a patient. These prosthetic valves may be configured to provide complimentary features that promote optimal placement of the prosthetic valve in a native heart valve, such as the aortic valve, mitral valve, pulmonic valve, and/or tricuspid valve. The delivery device includes a release sheath assembly housed within an outer delivery sheath. A release sheath component of the assembly captures a portion of the prosthetic valve to the delivery device, and effectuates complete release of the prosthetic valve with retraction of the outer sheath.

摘要翻译： 用于经皮递送假体瓣膜至患者心脏的输送装置和方法。 这些假体瓣膜可被构造成提供促进人造瓣膜在天然心脏瓣膜（例如主动脉瓣，二尖瓣，肺静脉瓣和/或三尖瓣）中的最佳放置的互补特征。 输送装置包括容纳在外部输送护套内的释放护套组件。 组件的释放护套部件将一部分人工瓣膜捕获到输送装置，并通过外护套的缩回来实现人造瓣膜的完全释放。

公开(公告)号：US08414645B2

公开(公告)日：2013-04-09

申请号：US12870567

申请日：2010-08-27

申请人： Joshua Dwork ,  Patrick E. Macaulay ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Richard Spork ,  Don Huy Tran ,  Nathan B. Wiemeyer

发明人： Joshua Dwork ,  Patrick E. Macaulay ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Richard Spork ,  Don Huy Tran ,  Nathan B. Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412

摘要： Delivery devices and methods for percutaneously delivering a prosthetic valve to the heart of a patient. These prosthetic valves may be configured to provide complimentary features that promote optimal placement of the prosthetic valve in a native heart valve, such as the aortic valve, mitral valve, pulmonic valve, and/or tricuspid valve. The delivery device includes a release sheath assembly housed within an outer delivery sheath. A release sheath component of the assembly captures a portion of the prosthetic valve to the delivery device, and effectuates complete release of the prosthetic valve with retraction of the outer sheath.

摘要翻译： 用于经皮递送假体瓣膜至患者心脏的输送装置和方法。 这些假体瓣膜可被构造成提供促进人造瓣膜在天然心脏瓣膜（例如主动脉瓣，二尖瓣，肺静脉瓣和/或三尖瓣）中的最佳放置的互补特征。 输送装置包括容纳在外部输送护套内的释放护套组件。 组件的释放护套部件将一部分人工瓣膜捕获到输送装置，并通过外护套的缩回来实现人造瓣膜的完全释放。

公开(公告)号：US20110238168A1

公开(公告)日：2011-09-29

申请号：US13071274

申请日：2011-03-24

申请人： Gianfranco M. Pellegrini ,  Mike Krivoruchko ,  Finn O. Rinne ,  Matthew J. Rust

发明人： Gianfranco M. Pellegrini ,  Mike Krivoruchko ,  Finn O. Rinne ,  Matthew J. Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0036 ,  A61F2250/0039

摘要： A prosthetic valve including a wire frame having a generally tubular body portion, an interior area, a longitudinal axis, a first end comprising a plurality of crowns, and a second end comprising a greater number of crowns than the first end. The wire frame includes a plurality of adjacent rows of modified diamond-shaped structures extending between the first and second ends. The prosthetic valve further includes a valve structure that includes a plurality of leaflets and that is attached within the interior area of the wire frame.

摘要翻译： 一种假体阀，包括具有大致管状体部分的线框架，内部区域，纵向轴线，包括多个冠部的第一端部，以及包括比第一端部更多数量的牙冠的第二端部。 线框架包括在第一和第二端之间延伸的多个相邻行的改进的菱形结构。 假体瓣膜还包括阀结构，其包括多个传单并且附接在线框架的内部区域内。

公开(公告)号：US09480557B2

公开(公告)日：2016-11-01

申请号：US13071274

申请日：2011-03-24

申请人： Gianfranco M. Pellegrini ,  Mike Krivoruchko ,  Finn O. Rinne ,  Matthew J. Rust

发明人： Gianfranco M. Pellegrini ,  Mike Krivoruchko ,  Finn O. Rinne ,  Matthew J. Rust

IPC分类号： A61F2/82 ,  A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0036 ,  A61F2250/0039

摘要： A prosthetic valve including a wire frame having a generally tubular body portion, an interior area, a longitudinal axis, a first end comprising a plurality of crowns, and a second end comprising a greater number of crowns than the first end. The wire frame includes a plurality of adjacent rows of modified diamond-shaped structures extending between the first and second ends. The prosthetic valve further includes a valve structure that includes a plurality of leaflets and that is attached within the interior area of the wire frame.

摘要翻译： 一种假体阀，包括具有大致管状体部分的线框架，内部区域，纵向轴线，包括多个冠部的第一端部，以及包括比第一端部更多数量的牙冠的第二端部。 线框架包括在第一和第二端之间延伸的多个相邻行的改进的菱形结构。 假体瓣膜还包括阀结构，其包括多个传单并且附接在线框架的内部区域内。

公开(公告)号：US09320597B2

公开(公告)日：2016-04-26

申请号：US12750490

申请日：2010-03-30

申请人： Padraig J. Savage ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Matthew J. Rust

发明人： Padraig J. Savage ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Matthew J. Rust

IPC分类号： A61F2/24 ,  A61F2/95

CPC分类号： A61F2/2436 ,  A61F2/2427 ,  A61F2002/9534 ,  A61F2210/0014

摘要： A delivery system for percutaneously deploying a stented prosthetic heart valve. The system includes a delivery capsule and a recapture assembly. The capsule is configured to compressively retain the prosthesis. The recapture assembly includes a frame and sleeve attached to the frame. The recapture assembly is transitionable from a compressed arrangement to an expanded arrangement with a distally increasing diameter.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的输送系统。 该系统包括递送胶囊和再捕获组件。 胶囊被构造成压缩地保持假体。 重新捕获组件包括附接到框架的框架和套筒。 重新捕获组件可从压缩布置转变成具有向远端增加的直径的扩展布置。

公开(公告)号：US20120018525A1

公开(公告)日：2012-01-26

申请号：US13034569

申请日：2011-02-24

申请人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

发明人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

IPC分类号： B05B7/24

CPC分类号： A61M11/02 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M35/003 ,  B05B7/0012 ,  B05B7/0869

摘要： Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

摘要翻译： 具体方面提供了用于在宽范围的MMAD尺寸分布上产生颗粒的新型雾化器，从而消除了在产生所需颗粒尺寸时对冲击挡板的要求。 在特定方面，雾化装置与配置和定位以提供粒度过滤的远程颗粒过滤器部件通信。 在另外的方面，雾化装置与适合于赋予分散室内和离开分散室的颗粒所需的颗粒流动图案的颗粒分散室连通。 在另外的方面，雾化装置与鼻，眼，口或“附近”适配器连通。 新颖的装置提供雾化液体（例如经鼻腔，嗅觉区域和口腔）的靶向（例如鼻，眼，口服，局部附近），全身和/或局部递送。 另外的示例性方面涉及香料，香料，精油或药妆剂等的雾化和输送。

公开(公告)号：US08733342B2

公开(公告)日：2014-05-27

申请号：US13034569

申请日：2011-02-24

申请人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

发明人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

IPC分类号： A61M11/00

CPC分类号： A61M11/02 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M35/003 ,  B05B7/0012 ,  B05B7/0869

摘要： Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

摘要翻译： 具体方面提供了用于在宽范围的MMAD尺寸分布上产生颗粒的新型雾化器，从而消除了在产生所需颗粒尺寸时对冲击挡板的要求。 在特定方面，雾化装置与配置和定位以提供粒度过滤的远程颗粒过滤器部件通信。 在另外的方面，雾化装置与适合于赋予分散室内和离开分散室的颗粒所需的颗粒流动图案的颗粒分散室连通。 在另外的方面，雾化装置与鼻，眼，口或“附近”适配器连通。 新颖的装置提供雾化液体（例如经鼻腔，嗅觉区域和口腔）的靶向（例如鼻，眼，口服，局部附近），全身和/或局部递送。 另外的示例性方面涉及香料，香料，精油或药妆剂等的雾化和输送。

公开(公告)号：US07905229B2

公开(公告)日：2011-03-15

申请号：US11848225

申请日：2007-08-30

申请人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

发明人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

IPC分类号： A61M11/00 ,  B05B1/26

CPC分类号： A61M11/02 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M35/003 ,  B05B7/0012 ,  B05B7/0869

摘要： Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

摘要翻译： 具体方面提供了用于在宽范围的MMAD尺寸分布上产生颗粒的新型雾化器，从而消除了在产生所需颗粒尺寸时对冲击挡板的要求。 在特定方面，雾化装置与配置和定位以提供粒度过滤的远程颗粒过滤器部件通信。 在另外的方面，雾化装置与适合于赋予分散室内和离开分散室的颗粒所需的颗粒流动图案的颗粒分散室连通。 在另外的方面，雾化装置与鼻，眼，口或“附近”适配器连通。 新颖的装置提供雾化液体（例如经鼻腔，嗅觉区域和口腔）的靶向（例如鼻，眼，口服，局部附近），全身和/或局部递送。 另外的示例性方面涉及香料，香料，精油或药妆剂等的雾化和输送。

公开(公告)号：US20080054099A1

公开(公告)日：2008-03-06

申请号：US11848225

申请日：2007-08-30

申请人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

发明人： Marc Giroux ,  William A. DeGroodt ,  Joseph R. Pearce ,  Robert W. Kamp ,  Finn O. Rinne ,  Paul C. Leung

IPC分类号： B05B7/32

CPC分类号： A61M11/02 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M35/003 ,  B05B7/0012 ,  B05B7/0869

摘要： Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

摘要翻译： 具体方面提供了用于在宽范围的MMAD尺寸分布上产生颗粒的新型雾化器，从而消除了在产生所需颗粒尺寸时对冲击挡板的要求。 在特定方面，雾化装置与配置和定位以提供粒度过滤的远程颗粒过滤器部件通信。 在另外的方面，雾化装置与适合于赋予分散室内和离开分散室的颗粒所需的颗粒流动图案的颗粒分散室连通。 在另外的方面，雾化装置与鼻，眼，口或“附近”适配器连通。 新颖的装置提供雾化液体（例如经鼻腔，嗅觉区域和口腔）的靶向（例如鼻，眼，口服，局部附近），全身和/或局部递送。 另外的示例性方面涉及香料，香料，精油或药妆剂等的雾化和输送。