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公开(公告)号:US08785605B2
公开(公告)日:2014-07-22
申请号:US13075241
申请日:2011-03-30
申请人: Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
发明人: Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
IPC分类号: C07K16/24 , A61K9/19 , A61K39/395
CPC分类号: C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要翻译: 本发明涉及结合人IL-25的指定表位的靶结合成员(例如抗体)。 本发明还涉及包含一个或多个人源化抗体VL结构域序列并结合IL-25的靶结合成员(例如抗体)。 本发明还涉及包含结合IL-25的靶结合成员(例如,抗体),产生此类靶结合成员的方法,以及这些靶结合成员用于治疗或预防疾病和病症(例如,哮喘, 炎性肠病)。
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公开(公告)号:US20110318353A1
公开(公告)日:2011-12-29
申请号:US13075241
申请日:2011-03-30
申请人: Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
发明人: Juan Carlos Almagro , Patrick Branigan , Colleen Kane , William Strohl , Susann Taudte , Mark Tornetta , John Wheeler
IPC分类号: A61K39/395 , C12N15/13 , C12N15/63 , A61P29/00 , C12N1/21 , C12P21/00 , C12P21/02 , A61P11/06 , C07K16/24 , C12N5/10
CPC分类号: C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要翻译: 本发明涉及结合人IL-25的指定表位的靶结合成员(例如抗体)。 本发明还涉及包含一个或多个人源化抗体VL结构域序列并结合IL-25的靶结合成员(例如,抗体)。 本发明还涉及包含结合IL-25的靶结合成员(例如,抗体),产生此类靶结合成员的方法,以及这些靶结合成员用于治疗或预防疾病和病症(例如,哮喘, 炎性肠病)。
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3.Anti-Respiratory Syncytial Virus Antibodies, Antigens and Uses Thereof 审中-公开
标题翻译: 抗呼吸道合胞病毒抗体,抗原及其用途公开(公告)号:US20110027294A1
公开(公告)日:2011-02-03
申请号:US12900924
申请日:2010-10-08
申请人: Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Chalapathi Koka
发明人: Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Chalapathi Koka
IPC分类号: A61K39/155 , C07K16/10 , A61K39/42 , C07H21/04 , C07K7/08 , A61P31/14 , C12N15/63 , C12P21/02 , C12N5/10 , C12N5/20
CPC分类号: C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K47/60 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/18522 , C12N2760/18534
摘要: Anti-Respiratory Syncytial Virus (RSV) monoclonal antibodies, RSV F protein antigens and their uses are disclosed.
摘要翻译: 公开了抗呼吸道合胞病毒(RSV)单克隆抗体,RSV F蛋白抗原及其用途。
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4.Anti-respiratory syncytial virus antibodies, antigens and uses thereof 审中-公开
标题翻译: 抗呼吸道合胞病毒抗体,抗原及其用途公开(公告)号:US20060159695A1
公开(公告)日:2006-07-20
申请号:US11261356
申请日:2005-10-28
申请人: Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Koka
发明人: Alfred Delvecchio , Ping Tsui , Patrick Branigan , Leslee Conrad , Nicole Day , Changbao Liu , Raymond Sweet , Sheng-Jiun Wu , Jose Melero , Jinquan Luo , Gabriela Canziani , Mark Tornetta , Gopalan Raghunathan , Venkata Koka
CPC分类号: C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K47/60 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/18522 , C12N2760/18534
摘要: Anti-Respiratory Syncytial Virus (RSV) monoclonal antibodies, RSV F protein antigens and their uses are disclosed.
摘要翻译: 公开了抗呼吸道合胞病毒(RSV)单克隆抗体,RSV F蛋白抗原及其用途。
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公开(公告)号:US08574582B2
公开(公告)日:2013-11-05
申请号:US12606575
申请日:2009-10-27
申请人: Patrick Branigan , Jason Ekert
发明人: Patrick Branigan , Jason Ekert
IPC分类号: A61K39/395 , A61K38/02 , A61P37/00 , A61P17/00
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/73 , G01N33/5044 , Y02A50/57
摘要: Methods for mediating fibrotic response by modulating IL-25 signaling in fibrocytes are disclosed.
摘要翻译: 公开了通过调节纤维细胞中IL-25信号转导来调节纤维化反应的方法。
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公开(公告)号:US20100111968A1
公开(公告)日:2010-05-06
申请号:US12606575
申请日:2009-10-27
申请人: Patrick Branigan , Jason Ekert
发明人: Patrick Branigan , Jason Ekert
IPC分类号: A61K39/395 , A61K38/02 , A61K31/7088 , A61P43/00 , A61P11/00 , A61P35/00 , A61P17/02 , A61P37/00 , C12Q1/02
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/73 , G01N33/5044 , Y02A50/57
摘要: Methods for mediating fibrotic response by modulating IL-25 signaling in fibrocytes are disclosed.
摘要翻译: 公开了通过调节纤维细胞中IL-25信号转导来调节纤维化反应的方法。
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公开(公告)号:US20060246061A1
公开(公告)日:2006-11-02
申请号:US11477036
申请日:2006-06-28
申请人: M. MBow , Patrick Branigan , Jill Giles-Komar , Linda Snyder , George Heavner
发明人: M. MBow , Patrick Branigan , Jill Giles-Komar , Linda Snyder , George Heavner
IPC分类号: A61K39/395 , C12P21/04
CPC分类号: C07K16/24 , A61K31/00 , A61K39/3955 , A61K45/06 , A61K2039/53 , A61K2039/57 , C07K16/00 , A61K2300/00
摘要: Methods for generating monoclonal antibodies in Th1-biased rodents are disclosed. The monoclonal antibodies are useful as therapeutic agents, diagnostic agents or research reagents.
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公开(公告)号:US20050261213A1
公开(公告)日:2005-11-24
申请号:US10401386
申请日:2003-03-28
申请人: Patrick Branigan , Theresa Goletz , David Knight , Stephen McCarthy , Bernard Scallon , Linda Snyder
发明人: Patrick Branigan , Theresa Goletz , David Knight , Stephen McCarthy , Bernard Scallon , Linda Snyder
CPC分类号: A61K39/0011 , A61K2039/53 , A61K2039/55522 , A61K2300/00
摘要: Polynucleotide compositions encoding a tumor antigen antigenic determinant and optionally including a nucleic acid adjuvant are disclosed. The compositions are useful for prophylaxis or treatment of cancer.
摘要翻译: 公开了编码肿瘤抗原抗原决定簇并任选包含核酸佐剂的多核苷酸组合物。 该组合物可用于预防或治疗癌症。
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