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公开(公告)号：US20130266669A1
公开(公告)日：2013-10-10
申请号：US13266570
申请日：2010-12-22
申请人： Juan Jiang , Jeffrey Melzer , Wilson Kurt Whitekettle , Guixi Zhang , Qing Zhao
发明人： Juan Jiang , Jeffrey Melzer , Wilson Kurt Whitekettle , Guixi Zhang , Qing Zhao
IPC分类号： A01N65/00
CPC分类号： A01N65/00 , A01N61/00 , C02F1/441 , C02F1/50 , C02F1/54 , C02F2103/023 , C02F2303/20 , A01N25/10
摘要： A method has been found for the inhibition of microbial biofilm on surfaces in contact with systems, such as aqueous systems. In accordance with the method, an effective amount of a modified tannin biofilm control agent is fed to the system water. The modified tannin biofilm control agent comprises a reaction product of an amine, an aldehyde and tannin and provides a good environmental profile.
摘要翻译： 已经发现在与系统接触的表面上抑制微生物生物膜的方法，例如水系统。 根据该方法，将有效量的改性单宁生物膜控制剂加入系统水中。 修饰的单宁生物膜控制剂包括胺，醛和单宁的反应产物，并提供良好的环境特性。
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公开(公告)号：US08784659B2
公开(公告)日：2014-07-22
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20110052656A1
公开(公告)日：2011-03-03
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： A01N25/26 , A61K31/04 , A01N43/78 , A01N33/02 , A01N47/00 , A01N37/52 , A01N43/66 , A01N57/34 , A01N35/00 , A01N37/44 , A01N43/88 , A01N43/80 , A01N59/20 , A01N59/16 , A01N59/08 , A01N59/24 , A01N39/00 , A01N59/26 , A01P1/00
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US07824557B2
公开(公告)日：2010-11-02
申请号：US11835722
申请日：2007-08-08
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/20 , C02F2305/14 , Y10S210/916 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物活性的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20120114728A1
公开(公告)日：2012-05-10
申请号：US13257211
申请日：2010-02-12
IPC分类号： A01N25/26 , A01N37/34 , A01N33/20 , A01N57/20 , A01P1/00 , A01N43/80 , A01N33/12 , B82Y99/00
CPC分类号： A61K31/425 , A01N25/28 , A01N43/80
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存 坦克 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。 此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。 在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少 降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20090039035A1
公开(公告)日：2009-02-12
申请号：US11835722
申请日：2007-08-08
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/20 , C02F2305/14 , Y10S210/916 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物活性的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US07785478B2
公开(公告)日：2010-08-31
申请号：US11835717
申请日：2007-08-08
IPC分类号： C02F1/50
CPC分类号： A01N25/28 , Y10S514/963 , A01N33/12 , A01N47/44 , A01N57/20
摘要： A method for controlling protozoa trophozites and cysts wherein biocides or control agents are encapsulated within microcapsules or manufactured into the core of liposomes, thereafter the biocide containing microcapsules or liposomes are then introduced into an aqueous system.
摘要翻译： 一种用于控制原生动物滋养细胞和囊肿的方法，其中将杀生物剂或控制剂包封在微胶囊内或制成脂质体核心，然后将含有微胶囊或脂质体的杀生物剂引入含水体系中。
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公开(公告)号：US20100239627A1
公开(公告)日：2010-09-23
申请号：US12408059
申请日：2009-03-20
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存 坦克 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。 此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。 在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少 降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20100239650A1
公开(公告)日：2010-09-23
申请号：US12407953
申请日：2009-03-20
IPC分类号： A61K9/127 , A61K31/425
CPC分类号： A61K31/425 , A01N25/28 , A01N43/80
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存 坦克 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。 此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。 在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少 降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20090039034A1
公开(公告)日：2009-02-12
申请号：US11835717
申请日：2007-08-08
IPC分类号： C02F1/50
CPC分类号： A01N25/28 , Y10S514/963 , A01N33/12 , A01N47/44 , A01N57/20
摘要： A method for controlling protozoa trophozites and cysts wherein biocides or control agents are encapsulated within microcapsules or manufactured into the core of liposomes, thereafter the biocide containing microcapsules or liposomes are then introduced into an aqueous system.
摘要翻译： 一种用于控制原生动物滋养细胞和囊肿的方法，其中将杀生物剂或控制剂包封在微胶囊内或制成脂质体核心，然后将含有微胶囊或脂质体的杀生物剂引入含水体系中。
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