-
公开(公告)号:US20100216866A1
公开(公告)日:2010-08-26
申请号:US12728139
申请日:2010-03-19
IPC分类号: A61K31/713 , C07H21/02 , A61P3/06 , A61P9/10 , A61P7/02
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US07723317B2
公开(公告)日:2010-05-25
申请号:US12400744
申请日:2009-03-09
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US07528118B2
公开(公告)日:2009-05-05
申请号:US11235385
申请日:2005-09-26
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US08592571B2
公开(公告)日:2013-11-26
申请号:US13450886
申请日:2012-04-19
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US20120252872A1
公开(公告)日:2012-10-04
申请号:US13450886
申请日:2012-04-19
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US08188061B2
公开(公告)日:2012-05-29
申请号:US12728139
申请日:2010-03-19
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US20090312397A1
公开(公告)日:2009-12-17
申请号:US12400744
申请日:2009-03-09
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
摘要翻译: 本发明涉及用于调节载脂蛋白B的表达的组合物和方法,更具体地涉及通过化学修饰的寡核苷酸下载载脂蛋白B的方法。
-
公开(公告)号:US20060105976A1
公开(公告)日:2006-05-18
申请号:US11235385
申请日:2005-09-26
CPC分类号: C12N15/113 , A61K31/7105 , A61K31/718 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
-
公开(公告)号:US07928217B2
公开(公告)日:2011-04-19
申请号:US11139089
申请日:2005-05-27
申请人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
发明人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
CPC分类号: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
摘要翻译: 本发明涉及在细胞和生物流体中具有改善的稳定性的修饰的双链寡核糖核酸(dsRNA),以及制备和鉴定具有改善的稳定性的dsRNA的方法,以及使用dsRNA抑制靶基因的表达或功能。
-
10.
公开(公告)号:US07902168B2
公开(公告)日:2011-03-08
申请号:US12487605
申请日:2009-06-18
申请人: Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
发明人: Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
CPC分类号: C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521
摘要: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
摘要翻译: 本发明涉及用于抑制Nav1.8基因(Nav1.8基因)表达的双链核糖核酸(dsRNA),其包含具有长度小于25个核苷酸的核苷酸序列的反义链,其基本上 与Nav1.8基因的至少一部分互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由使用该药物组合物的Nav1.8基因表达引起的疾病的方法; 以及抑制细胞中Nav1.8基因表达的方法。
-
-
-
-
-
-
-
-
-