-
公开(公告)号：US08131362B2
公开(公告)日：2012-03-06
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
-
公开(公告)号：US20090306734A1
公开(公告)日：2009-12-10
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
-
公开(公告)号：US07587238B2
公开(公告)日：2009-09-08
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
-
4.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
-
5.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07260431B2
公开(公告)日：2007-08-21
申请号：US10850341
申请日：2004-05-20
IPC分类号： A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
-
6.发明申请COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权可重构心脏器械组合重组控制治疗与抗再感染治疗公开(公告)号：US20110015692A1
公开(公告)日：2011-01-20
申请号：US12891674
申请日：2010-09-27
IPC分类号： A61N1/365
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
-
7.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US08483828B2
公开(公告)日：2013-07-09
申请号：US12891674
申请日：2010-09-27
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
-
公开(公告)号：US20060206154A1
公开(公告)日：2006-09-14
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce KenKnight , Imad Libbus
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
-
9.发明申请公开(公告)号：US20060206153A1
公开(公告)日：2006-09-14
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
发明人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
-
10.发明授权Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权用于选择治疗慢性心脏功能障碍的颈部迷走神经电刺激治疗方案的计算机实现系统和方法公开(公告)号：US08630709B2
公开(公告)日：2014-01-14
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译： 提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。 外部编程器包括存储在存储器中的多个治疗简档。 治疗概况包括不同组的刺激参数，其协作地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。 编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。 最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。 可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极治疗性地刺激颈部迷走神经。
-
-
-
-
-
-
-
-
-
搜索结果
346 条记录 (耗时 0.027 秒)