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    UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES
    1.
    发明申请
    UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES 有权
    紫外线过滤器组合包含苄基胆碱酯

    公开(公告)号：US20120128611A1

    公开(公告)日：2012-05-24

    申请号：US13381965

    申请日：2010-06-29

    申请人： Julie Grumelard ,  Thomas Ehlis ,  Paul Adriaan Van Der Schaaf ,  Markus Hansch ,  Myriam Sohn

    发明人： Julie Grumelard ,  Thomas Ehlis ,  Paul Adriaan Van Der Schaaf ,  Markus Hansch ,  Myriam Sohn

    IPC分类号： A61K8/37 ,  A61K8/49 ,  A61K8/58 ,  A61Q17/04

    CPC分类号： A61Q17/04 ,  A61K8/37

    摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.

    摘要翻译： 公开了使用UV过滤器组合，其包含（a）选自式（1）的亚苄基丙二酸酯的第一UV过滤器，其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，那么R是叔丁基。 丁基; 式（II）; 式（III）; 式（1a）的基团; 或式（1b）的基团; 其中R2和R3彼此独立地是氢; 或甲基; R4是甲基; 乙基; 或正丙基​​; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，那么R是异丙基; 和（b）选自（b1）双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤器; （b2）丁基甲氧基二苯甲酰甲烷; （b3）丁酰己二酸二乙基己酯; （b4）乙基己基三嗪酮; （b5）二乙基氨基羟基苯甲酰己基苯甲酸酯; （b6）甲氧基肉桂酸乙基己酯; （b7）水杨酸乙基己酯; （b8）均质酸; （b9） （b10）微米亚甲基双苯并三唑基四甲基丁基苯酚; （b11）苯基苯并咪唑磺酸; （b12）二氧化钛; （b13）微粉化的三联苯三嗪; 和（b14）微粉化（2- {4- [2-（4-二乙基氨基-2-羟基 - 苯甲酰基） - 苯甲酰基] - 哌嗪-1-羰基} - 苯基） - （4-二乙基氨基-2-羟基 - 苯基） 甲酮 （b15）苯甲酸，4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 ，4-二基]二亚氨基]双 - 二丁酯，其中UV滤光器组合包含至少2个组分（b1） - （b14）的UV滤光剂; 用于保护人和动物的头发和皮肤免受紫外线辐射。

    UV filter combinations comprising benzylidene malonates
    2.
    发明授权
    UV filter combinations comprising benzylidene malonates 有权

    公开(公告)号：US09764169B2

    公开(公告)日：2017-09-19

    申请号：US13381965

    申请日：2010-06-29

    申请人： Julie Grumelard ,  Thomas Ehlis ,  Markus Hansch ,  Myriam Sohn

    发明人： Julie Grumelard ,  Thomas Ehlis ,  Markus Hansch ,  Myriam Sohn

    IPC分类号： A61Q17/04 ,  A61K8/37

    CPC分类号： A61Q17/04 ,  A61K8/37

    摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;(b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.

    CRYSTAL MODIFICATIONS OF TRANSMISSION DYES
    4.
    发明申请
    CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 有权
    传染性染色体的晶体修饰

    公开(公告)号：US20100144753A1

    公开(公告)日：2010-06-10

    申请号：US12597930

    申请日：2008-04-28

    申请人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    发明人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    IPC分类号： A61K31/4965

    CPC分类号： C07D295/192 ,  A61K8/04 ,  A61K8/494 ,  A61K31/495 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

    摘要翻译： 公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰 在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。 新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

    Crystal modifications of transmission dyes
    5.
    发明授权
    Crystal modifications of transmission dyes 有权
    透射染料的水晶修饰

    公开(公告)号：US08557820B2

    公开(公告)日：2013-10-15

    申请号：US12597930

    申请日：2008-04-28

    申请人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    发明人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    IPC分类号： A61K31/497 ,  A61K8/00 ,  C07D241/04 ,  C07D295/00 ,  A61Q17/04

    CPC分类号： C07D295/192 ,  A61K8/04 ,  A61K8/494 ,  A61K31/495 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

    摘要翻译： 公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰 在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。 新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

    GRINDING AIDES FOR MICRONIZED ORGANIC UV ABSORBERS
    6.
    发明申请
    GRINDING AIDES FOR MICRONIZED ORGANIC UV ABSORBERS 审中-公开
    微波有机紫外线吸收剂研磨助剂

    公开(公告)号：US20100303746A1

    公开(公告)日：2010-12-02

    申请号：US12744495

    申请日：2008-11-20

    申请人： Sebastien Mongiat ,  Julie Grumelard ,  Thomas Ehlis

    发明人： Sebastien Mongiat ,  Julie Grumelard ,  Thomas Ehlis

    IPC分类号： A61K8/49 ,  A61Q17/04

    CPC分类号： A61Q17/04 ,  A61K8/494 ,  A61K2800/412

    摘要： A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b1) carboxylic acids and their salts; (b2) fatty acid esters (b3) alkyl phosphates or phosphoric acid esters; (b4) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b5) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b6) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C4-C28 fatty acids; (b7) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b8) esters of polyol and mono-, di- or tri-glycerides; (b9) esters of fatty acids and saccharose; (b10) sorbitan mono- and di-esters of saturated and/or unsaturated C6-C22 fatty acids and ethylene oxide groups; and (b11) surfactants which are mainly acting as detergent or cleansing agents.

    摘要翻译： 一种制备组合物的方法，包括（a）微粉化的不溶性有机UV吸收剂，该方法包括在研磨装置中，在选自以下组的研磨助剂的存在下研磨粗颗粒形式的不溶性有机UV吸收剂（ b1）羧酸及其盐; （b2）脂肪酸酯（b3）磷酸烷基酯或磷酸酯; （b4）乙氧基化羧酸或聚乙二醇（PEG）酯; （b5）脂肪醇的脂肪醇聚乙二醇（PEG）醚; （b6）饱和或不饱和C4-C28脂肪酸的聚乙烯/聚丙二醇醚; （b7）乙氧基化烷基酚或乙氧基化烷基苯基醚; （b8）多元醇和甘油单酯，甘油二酯或甘油酯的酯; （b9）脂肪酸和蔗糖的酯; （b10）饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和（b11）主要作为洗涤剂或清洁剂的表面活性剂。

    BENZYLIDENE MALONATES
    7.
    发明申请
    BENZYLIDENE MALONATES 审中-公开
    苯并噻唑啉酮

    公开(公告)号：US20120128745A1

    公开(公告)日：2012-05-24

    申请号：US13322628

    申请日：2010-05-19

    申请人： Markus Hansch ,  Thomas Ehlis ,  Olof Wallquist ,  Barbara Wagner ,  Bernd Herzog ,  Jochen Giesinger

    发明人： Markus Hansch ,  Thomas Ehlis ,  Olof Wallquist ,  Barbara Wagner ,  Bernd Herzog ,  Jochen Giesinger

    IPC分类号： A61K8/02 ,  C07C69/734 ,  A61K8/41 ,  A61K8/49 ,  A61K8/37 ,  A61Q17/04

    CPC分类号： A61K8/37 ,  A61Q17/04 ,  C07C69/73

    摘要： Disclosed is the use of benzylidene malonates of formula (1) wherein R1 is methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; a radical of formula (1a) or a radical of formula (1b) wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; for the protection of human and animal hair and skin against UV radiation.

    摘要翻译： 公开了使用式（1）的亚苄基丙二酸酯，其中R 1是甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基，那么R是叔丁基。 丁基; 式（1a）的基团或式（1b）的基团，其中R2和R3彼此独立地为氢; 或甲基; R4是甲基; 乙基; 或正丙基​​; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基，那么R是异丙基; 用于保护人和动物的头发和皮肤免受紫外线辐射。

    DIMERIC BENZYLIDENE MALONATES
    9.
    发明申请
    DIMERIC BENZYLIDENE MALONATES 审中-公开
    二甲苯胆碱

    公开(公告)号：US20110038815A1

    公开(公告)日：2011-02-17

    申请号：US12867777

    申请日：2009-03-04

    申请人： Markus Hansch ,  Thomas Ehlis ,  Barbara Wagner

    发明人： Markus Hansch ,  Thomas Ehlis ,  Barbara Wagner

    IPC分类号： A61K8/37 ,  C07C67/31 ,  A61Q17/04

    CPC分类号： A61Q17/04 ,  A61K8/37 ,  A61K8/585 ,  C07C67/03 ,  C07C67/31 ,  C07C67/343 ,  C07C69/734 ,  C07C2601/14 ,  C07F7/0889 ,  C07C69/732

    摘要： Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is —C1-C20alkylene-, —CH2CH(OH)CH2—, —C5-C20cycloalkylene, —C2-C20alkenylene-, —C5-C10arylene-, or —C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from —O, —S— or —NH—; for the protection of human and animal hair and skin against UV radiation.

    摘要翻译： 公开了式（1）的亚苄基丙二酸酯的用途，其中R 1和R 2彼此独立地为氢; 哦; C 1 -C 12烷基; C1-C12烷氧基; C 1 -C 12烷基氨基; C1-C12二烷基氨基; 选自羧酸盐，磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7，R 4为COOR 8; COR9; CONR8R9; CN; 或SO2R10; R 5，R 6，R 7，R 8，R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代或取代的-C 1 -C 20亚烷基 - ， - CH 2 CH（OH）CH 2 - ， - C 5 -C 20亚环烷基，-C 2 -C 20亚烯基，-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - （C 1 -C 10亚烷基） 直链或支链，任选被一个或多于一个选自-O，-S-或-NH-的杂原子中断; 用于保护人和动物的头发和皮肤免受紫外线辐射。