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    CRYSTAL MODIFICATIONS OF TRANSMISSION DYES
    1.
    发明申请
    CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 有权
    传染性染色体的晶体修饰

    公开(公告)号：US20100144753A1

    公开(公告)日：2010-06-10

    申请号：US12597930

    申请日：2008-04-28

    申请人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    发明人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    IPC分类号： A61K31/4965

    CPC分类号： C07D295/192 ,  A61K8/04 ,  A61K8/494 ,  A61K31/495 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

    摘要翻译： 公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰 在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。 新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

    Crystal modifications of transmission dyes
    2.
    发明授权
    Crystal modifications of transmission dyes 有权
    透射染料的水晶修饰

    公开(公告)号：US08557820B2

    公开(公告)日：2013-10-15

    申请号：US12597930

    申请日：2008-04-28

    申请人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    发明人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

    IPC分类号： A61K31/497 ,  A61K8/00 ,  C07D241/04 ,  C07D295/00 ,  A61Q17/04

    CPC分类号： C07D295/192 ,  A61K8/04 ,  A61K8/494 ,  A61K31/495 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

    摘要翻译： 公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰 在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。 新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

    Hydroxybenzophenone Derivatives
    4.
    发明申请
    Hydroxybenzophenone Derivatives 有权
    羟基二苯甲酮衍生物

    公开(公告)号：US20090220439A1

    公开(公告)日：2009-09-03

    申请号：US12223686

    申请日：2007-02-06

    申请人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

    发明人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

    IPC分类号： A61K8/58 ,  C07F7/10 ,  A61Q17/04

    CPC分类号： A61Q17/04 ,  A61K8/585 ,  C07F7/0838

    摘要： Disclosed are hydroxyphenylbenzophenone derivatives of formula (1), wherein R1 and R2 independently from each other are hydrogen; C1-C20alkenyl; C3-C10cycloalkyl; or R1 and R2 together with the linking nitrogen atom form a 5- 6-membered heterocyclic ring; R3, R4 and R5 independently from each other are C1-C4alkyl; C1-C4alkoxy; or a radical of formula (1a) R6 is C1-C6alkyl; and A is a straight-chain or branched C3-C6alkylene, which is optionally interrupted by one or more *—O—*, or *—O—(CO)—* groups; and m is 0; or a number from 1 to 5. The compounds are useful as cosmetic UV filters with outstanding solubility properties in cosmetic oils.

    摘要翻译： 公开了式（1）的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是氢; C1-C20烯基; C 3 -C 10环烷基; 或R 1和R 2与连接氮原子一起形成5-6元杂环; R 3，R 4和R 5彼此独立地为C 1 -C 4烷基; C1-C4烷氧基; 或式（1a）的基团，R 6为C 1 -C 6烷基; 并且A是直链或支链C 3 -C 6亚烷基，其任选地被一个或多个* -O- *或* -O-（CO）*基团间隔; m为0; 或1至5的数字。该化合物可用作化妆品油中具有优异溶解性的化妆品UV过滤器。

    Hydroxybenzophenone derivatives
    5.
    发明授权
    Hydroxybenzophenone derivatives 有权
    羟基二苯甲酮衍生物

    公开(公告)号：US07999128B2

    公开(公告)日：2011-08-16

    申请号：US12223686

    申请日：2007-02-06

    申请人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

    发明人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

    IPC分类号： C07F7/04

    CPC分类号： A61Q17/04 ,  A61K8/585 ,  C07F7/0838

    摘要： Disclosed are hydroxyphenylbenzophenone derivatives of formula (1), wherein R1 and R2 independently from each other are hydrogen; C1-C20alkenyl; C3-C10cycloalkyl; or R1 and R2 together with the linking nitrogen atom form a 5- 6-membered heterocyclic ring; R3, R4 and R5 independently from each other are C1-C4alkyl; C1-C4alkoxy; or a radical of formula (1a) R6 is C1-C6alkyl; and A is a straight-chain or branched C3-C6alkylene, which is optionally interrupted by one or more *—O—*, or *—O—(CO)—* groups; and m is 0; or a number from 1 to 5. The compounds are useful as cosmetic UV filters with outstanding solubility properties in cosmetic oils.

    摘要翻译： 公开了式（1）的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是氢; C1-C20烯基; C 3 -C 10环烷基; 或R 1和R 2与连接氮原子一起形成5-6元杂环; R 3，R 4和R 5彼此独立地为C 1 -C 4烷基; C1-C4烷氧基; 或式（1a）的基团，R 6为C 1 -C 6烷基; 并且A是直链或支链C 3 -C 6亚烷基，其任选地被一个或多个* -O- *或* -O-（CO）*基团间隔; m为0; 或1至5的数字。该化合物可用作化妆品油中具有优异溶解性的化妆品UV滤光片。

    Amino substituted hydroxyphenyl benzophenone derivatives
    6.
    发明授权
    Amino substituted hydroxyphenyl benzophenone derivatives 有权
    氨基取代羟苯基二苯甲酮衍生物

    公开(公告)号：US07374749B2

    公开(公告)日：2008-05-20

    申请号：US10537940

    申请日：2003-12-03

    申请人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Müller

    发明人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Müller

    IPC分类号： A61K8/44 ,  A61K8/49 ,  C07D277/66 ,  C07D313/12 ,  C07C233/73 ,  C07C233/69 ,  C07C233/78 ,  C07C229/52

    CPC分类号： C07D295/192 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4973 ,  A61Q17/04 ,  C07C229/52 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D313/12

    摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.

    摘要翻译： 描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是; C 1 -C 20烷基; C 1 -C 20烷基; C 2 -C 20 - 烯基; C 3 -C 10环烷基; C 3 -C 10环烯基; 或R 1和R 2与连接氮原子一起形成5-或6-元杂环; n 1是1至4的数; 当n 1 = 1时，R 3 3是饱和或不饱和杂环基; 羟基-C 1 -C 5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基，氨基羰基或C 1 -C 5烷基羧基; 当n 1是2时，R 3是任选被羰基或羧基取代的亚烷基 - 亚环烷基 - 或亚烯基; R 3与A一起形成式（Ia）的二价基团，其中n 2是1至3的数; 当n 1为3时，R 3为烷三基; 当n 1为4时，R 3为烷基乙酰基; A为-O- 或-N（R 5） - ; 并且R 5是氢; C 1 -C 5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。

    Self Tanning Composition
    8.
    发明申请
    Self Tanning Composition 审中-公开
    自晒黑组合物

    公开(公告)号：US20090196894A1

    公开(公告)日：2009-08-06

    申请号：US12227769

    申请日：2007-05-21

    申请人： Thomas Ehlis ,  Stefan Müller ,  Sebastien Mongiat

    发明人： Thomas Ehlis ,  Stefan Müller ,  Sebastien Mongiat

    IPC分类号： A61K9/14 ,  A61K8/49

    CPC分类号： A61Q19/04 ,  A61K8/044 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/60 ,  A61K2800/31 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/10 ,  A61Q17/04 ,  B82Y5/00

    摘要： Disclosed is a method for the colouration of skin or a keratinic fibre, characterized in that the skin or keratinic fibre is contacted with a formulation containing a dispersion of solid particles of a tanning substance selected from a compound of the formula (I) wherein i is 0 or 1 and each of R1, R2, R3, R4, R5, R6, R7, R8 independently of each other is selected from group consisting of hydrogen, OH, C1-C6alkyl, C1-C6hydroxyalkyl and C2-C6al-kenyl; in an organic liquid of low polarity or non-polar organic liquid.

    摘要翻译： 公开了一种使皮肤或角质纤维着色的方法，其特征在于使皮肤或角质纤维与含有鞣制物质的固体颗粒分散体的制剂接触，所述鞣制物质的分散体选自式（I）的化合物，其中i是 R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8彼此独立地选自氢，OH，C 1 -C 6烷基，C 1 -C 6羟烷基和C 2 -C 6α-烯基; 在低极性的有机液体或非极性有机液体中。

    Symmetrical triazine derivatives
    10.
    发明授权
    Symmetrical triazine derivatives 有权
    对称三嗪衍生物

    公开(公告)号：US07311897B2

    公开(公告)日：2007-12-25

    申请号：US10804676

    申请日：2004-03-19

    申请人： Thomas Ehlis ,  Stefan Müller ,  Pascal Hayoz

    发明人： Thomas Ehlis ,  Stefan Müller ,  Pascal Hayoz

    IPC分类号： A61Q17/04 ,  A61Q19/00 ,  A61K8/00

    CPC分类号： C07D251/24 ,  A61K8/4966 ,  A61Q17/04

    摘要： Disclosed is the use of the compounds of formula wherein A is a radical of formula R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R2, R3 and R4 independently from each other are hydrogen; or a radical of formula wherein, in formula (1a), at least one of the radicals R2, R3 and R4 are a radical of formula (1c); R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; —COOM; C1-C18-alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The compounds of formula (1) are high effective UV absorbers for cosmetic formulations aund can be—depending on their physical properties be used in micronized or soluble form.

    摘要翻译： 公开了下式化合物的用途，其中A是式R 1和R 5的基团彼此独立地是氢; C 1 -C 18烷基; 或C 6 -C 12 - 芳基; R 2，R 3和R 4彼此独立地是氢; 或式（1a）的基团，其中在式（1a）中，基团R 2，R 3和R 4中的至少一个为 式（1c）的基团; R 6，R 7，R 8，R 9和R 10独立地是 彼此是氢; 羟基; 卤素; C 1 -C 18烷基; C 1 -C 18烷氧基; C 6 -C 12芳基; 联苯基 C 6 -C 12芳氧基; C 1 -C 18烷硫基; 羧基; -COOM; C 1 -C 18 - 烷基羧基; 氨基羰基; 或单或二-C 1 -C 18烷基氨基; C 1 -C 10酰基氨基; -COOH; M是碱金属离子; x为1或2; y为2〜10的数; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。 式（1）的化合物是用于化妆品制剂的高效UV吸收剂，可以取决于它们以微粉化或可溶形式使用的物理性质。