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公开(公告)号:US08449882B2
公开(公告)日:2013-05-28
申请号:US12713041
申请日:2010-02-25
申请人: Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
发明人: Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
IPC分类号: A61K39/395
CPC分类号: C07K16/28 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要: Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要翻译: 要解决的问题旨在提供具有抑制细胞恶性转化和/或肿瘤细胞生长等的活性的抗体。溶液本发明提供一种抗体,其识别由杂交瘤SH348-1产生的抗体识别的表位 (FERM BP-10836)或杂交瘤SH357-1(FERM BP-10837),由杂交瘤SH348-1或杂交瘤SH357-1产生的抗体,通过将由杂交瘤SH348-1产生的抗体人源化而获得的抗体或 杂交瘤SH357-1是包含抗体作为活性成分的药剂等
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公开(公告)号:US20100183618A1
公开(公告)日:2010-07-22
申请号:US12713041
申请日:2010-02-25
申请人: Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
发明人: Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
CPC分类号: C07K16/28 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要: Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要翻译: 要解决的问题旨在提供具有抑制细胞恶性转化和/或肿瘤细胞生长等的活性的抗体。溶液本发明提供一种抗体,其识别由杂交瘤SH348-1产生的抗体识别的表位 (FERM BP-10836)或杂交瘤SH357-1(FERM BP-10837),由杂交瘤SH348-1或杂交瘤SH357-1产生的抗体,通过将由杂交瘤SH348-1产生的抗体人源化而获得的抗体或 杂交瘤SH357-1是包含抗体作为活性成分的药剂等
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公开(公告)号:US07592140B2
公开(公告)日:2009-09-22
申请号:US11078951
申请日:2005-03-11
申请人: Kazuishi Kubota , Kaori Nakahara , Ayako Hara , Yohei Ozeki , Yasuteru Iijima
发明人: Kazuishi Kubota , Kaori Nakahara , Ayako Hara , Yohei Ozeki , Yasuteru Iijima
CPC分类号: C12Q1/44 , A61K38/00 , C12N9/22 , G01N2500/00
摘要: Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recombinant plasmid DNAs, processes for screening for 2′,5′-oligoadenylate phosphodiesterase activity inhibitor substances, and processes for screening for 2′,5′-oligoadenylate phosphodiesterase expression regulation inhibitor substances. The polypeptides, polynucleotides and host cells are useful for searching for therapeutic agents for viral infections and tumors.
摘要翻译: 具有2',5'-寡腺苷酸磷酸二酯酶活性的多肽,针对多肽的抗体,编码多肽的多核苷酸,插入多核苷酸的重组质粒DNA,由重组质粒DNA转化的宿主细胞,筛选2', 5'-寡腺苷酸磷酸二酯酶活性抑制剂物质,以及筛选2',5'-寡腺苷酸磷酸二酯酶表达调节抑制物质的方法。 多肽,多核苷酸和宿主细胞可用于寻找病毒感染和肿瘤的治疗剂。
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公开(公告)号:US20050272119A1
公开(公告)日:2005-12-08
申请号:US11078951
申请日:2005-03-11
申请人: Kazuishi Kubota , Kaori Nakahara , Ayako Hara , Yohei Ozeki , Yasuteru Iijima
发明人: Kazuishi Kubota , Kaori Nakahara , Ayako Hara , Yohei Ozeki , Yasuteru Iijima
IPC分类号: A61K38/00 , A61P31/12 , A61P35/00 , C07K16/40 , C12N1/21 , C12N9/22 , C12Q1/44 , C12N9/16 , C07H21/04
CPC分类号: C12Q1/44 , A61K38/00 , C12N9/22 , G01N2500/00
摘要: Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recombinant plasmid DNAs, processes for screening for 2′,5′-oligoadenylate phosphodiesterase activity inhibitor substances, and processes for screening for 2′,5′-oligoadenylate phosphodiesterase expression regulation inhibitor substances. The polypeptides, polynucleotides and host cells are useful for searching for therapeutic agents for viral infections and tumors.
摘要翻译: 具有2',5'-寡腺苷酸磷酸二酯酶活性的多肽,针对多肽的抗体,编码多肽的多核苷酸,插入多核苷酸的重组质粒DNA,由重组质粒DNA转化的宿主细胞,筛选2', 5'-寡腺苷酸磷酸二酯酶活性抑制剂物质,以及筛选2',5'-寡腺苷酸磷酸二酯酶表达调节抑制物质的方法。 多肽,多核苷酸和宿主细胞可用于寻找病毒感染和肿瘤的治疗剂。
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