摘要:
Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要:
Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要:
The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptor-expressing cells through apoptosis.[Object]An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer.[Means for Resolution]A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.
摘要:
The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptor-expressing cells through apoptosis.[Object]An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer.[Means for Resolution]A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.
摘要:
An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.
摘要:
An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.
摘要:
Provided is a pharmaceutical composition for treating and/or preventing abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.
摘要:
A stability control apparatus, includes: a grip detector that changes an output based on a grip force applied in a direction hindering a slippage of a wheel, acting on a contact face between the wheel supported by a wheel supporting rolling bearing unit and the road surface, the wheel supporting rolling bearing unit for supporting freely rotatably the wheel to a vehicle body; and a controller that performs a control for keeping a running stability of the vehicle in response to an input of a detection signal of the grip detector.
摘要:
A sensor unit is supported on a stationary ring which does not rotate even when it is in use, and the rotation of the rotary ring can be detected by a rotation detecting sensor held within the sensor unit. Within the sensor unit, besides the rotation detecting sensor, there are disposed other sensors such as a temperature sensor and a vibration sensor, thereby being able to detect the rotation speed and the rotation number of the wheel supported on the rotary ring, and the other car driving conditions.
摘要:
A wheel rotation detecting device including a sensor unit that is supported on a stationary ring which does not rotate even when the wheel is in use, and the rotation of the wheel that is attached to a rotary ring can be detected by a rotation detecting sensor held within the sensor unit. Within the sensor unit, in addition to a rotation detecting sensor, there are disposed other sensors such as a temperature sensor and a vibration sensor, thereby allowing detection of the rotation speed and the rotation number of the wheel supported on the rotary ring, as well as detection of other car driving conditions.