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    ANTI-ADHESION POLYMER COMPOSITION CAPABLE OF SUPPORTING GROWTH FACTOR
    1.
    发明申请
    ANTI-ADHESION POLYMER COMPOSITION CAPABLE OF SUPPORTING GROWTH FACTOR 有权
    抗粘合聚合物组合物可支持生长因子

    公开(公告)号：US20150010490A1

    公开(公告)日：2015-01-08

    申请号：US14374988

    申请日：2012-03-08

    申请人： Jung Ju Kim ,  Jung Won So ,  Hyun Seung Ryu ,  Jun Hyuk Seo

    发明人： Jung Ju Kim ,  Jung Won So ,  Hyun Seung Ryu ,  Jun Hyuk Seo

    IPC分类号： A61L24/04 ,  A61L24/00 ,  C08L71/02

    CPC分类号： A61L24/046 ,  A61B2090/0816 ,  A61K47/10 ,  A61K47/30 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/043 ,  A61L31/041 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2400/04 ,  A61L2400/06 ,  C08L71/02 ,  C08L2203/02 ,  C08L89/06 ,  C08L5/08

    摘要： The present invention relates to an anti-adhesion polymer composition capable of supporting growth factor, which effectively exhibits anti-adhesion function and, at the same time, has an excellent adhesive property so as to be able to easily and continuously adhere to a wound site, has antibacterial and hemostatic properties, and is composed of an injectable formulation suitable for use in minimally invasive surgery, laparoscopic surgery or the like. The anti-adhesion polymer composition capable of supporting growth factor comprises: 24-50 wt % of a polyethyleneglycol-polypropyleneglycol-polyethyleneglycol (PEG-PPG-PEG) block copolymer having a polyethyleneglycol (PEG) content of 65-85 wt % and a molecular weight of 6,000-20,000 Da; 0.03-5 wt % of gelatin; 0.03-5 wt % of chitosan; and distilled water.

    摘要翻译： 本发明涉及一种能够有效显示抗粘连功能的支持生长因子的抗粘连聚合物组合物，同时具有优异的粘合性能，从而能够容易地并且连续地附着于伤口部位 具有抗菌和止血特性，并且由适用于微创手术，腹腔镜手术等的可注射制剂组成。 能够支持生长因子的抗粘连聚合物组合物包括：具有聚乙二醇（PEG）含量为65-85重量％的聚乙二醇 - 聚丙二醇 - 聚乙二醇（PEG-PPG-PEG）嵌段共聚物的24-50重量％和分子量 重量6,000-20,000 Da; 0.03-5重量％的明胶; 0.03-5重量％的壳聚糖; 和蒸馏水。

    Transdermal preparations containing hydrophoic non-steroidal anti-inflammatory drugs
    4.
    发明授权
    Transdermal preparations containing hydrophoic non-steroidal anti-inflammatory drugs 有权
    含有疏水性非甾体抗炎药的透皮制剂

    公开(公告)号：US08728514B2

    公开(公告)日：2014-05-20

    申请号：US12084014

    申请日：2006-10-23

    申请人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

    发明人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7061 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196

    摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

    摘要翻译： 公开了含有疏水性药物的透皮制剂。 作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低 即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。 在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。 亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

    Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate
    6.
    发明申请
    Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate 审中-公开
    制备包含醋酸蔗糖异丁酸盐的缓释微粒的方法

    公开(公告)号：US20080286375A1

    公开(公告)日：2008-11-20

    申请号：US12093872

    申请日：2002-11-15

    申请人： Eun Seong Lee ,  Hyeok Lee ,  Jung Ju Kim

    发明人： Eun Seong Lee ,  Hyeok Lee ,  Jung Ju Kim

    IPC分类号： A61K9/14 ,  A61K38/16 ,  A61K38/47 ,  A61K38/28 ,  A61K38/14 ,  A61K38/21 ,  A61K39/395 ,  A61K38/20 ,  A61K38/48 ,  A61K38/44 ,  A61K39/12 ,  A61K38/30 ,  A61K38/27 ,  A61K38/18 ,  A61P43/00

    CPC分类号： A61K9/1647 ,  A61K9/19 ,  A61K47/14

    摘要： A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method including the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate (SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.

    摘要翻译： 可以简单地通过包括以下步骤的方法制备能够长时间连续释放蛋白质药物而没有药物初始爆发释放的持续释放微粒：a）将蛋白质药物溶解在水溶液中以获得 水相; b）将蔗糖乙酸异丁酸酯（SAIB）和可生物降解的聚合物溶于有机溶剂中以获得油相; c）将步骤a）中获得的水相加入到步骤b）中获得的油相中以形成初级乳液; 和d）将初级乳液加入到外部水性连续相中以形成二次乳液并回收在二次乳液中形成的固体产物。

    TRANSDERMAL ABSORPTION PREPARATION
    8.
    发明申请
    TRANSDERMAL ABSORPTION PREPARATION 审中-公开
    超吸收制剂

    公开(公告)号：US20130165875A1

    公开(公告)日：2013-06-27

    申请号：US13642960

    申请日：2011-04-21

    申请人： Young Kweon Choi ,  Jung Ju Kim ,  Seong Su Kim ,  Jung Sik Lee ,  Seong Min Park

    发明人： Young Kweon Choi ,  Jung Ju Kim ,  Seong Su Kim ,  Jung Sik Lee ,  Seong Min Park

    IPC分类号： A61M35/00

    CPC分类号： A61K9/7061 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/4045

    摘要： The present, invention relates to a transdermal absorption preparation. The transdermal absorption preparation of the present invention comprises a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, rubber, an adhesion-imparting resin, an antioxidant, and a transdermal absorption promoter. Also, the present invention provides a transdermal absorption preparation comprising a drug-containing adhesive layer, a drug-protective layer, and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, acrylic rubber, an anti-crystallisation agent, and a transdermal absorption promoter. When the transdermal absorption preparation of the present invention is used for the treatment of Parkinson's disease or restless leg syndrome, no side effect due to an increase in the initial drug concentration in blood occurs and the skin penetration effect of the drug is excellent.

    摘要翻译： 本发明涉及一种透皮吸收制剂。 本发明的透皮吸收制剂包含含药物的粘合剂层，药物保护层和剥离层，其中含药物的粘合剂层含有罗哌尼罗或其盐，橡胶，赋形树脂，抗氧化剂 ，和透皮吸收促进剂。 另外，本发明提供了含有药物的粘合剂层，药物保护层和剥离层的透皮吸收制剂，其中含药物的粘合剂层含有罗哌尼罗或其盐，丙烯酸橡胶，抗结晶 试剂和透皮吸收促进剂。 当本发明的经皮吸收制剂用于治疗帕金森病或不宁腿综合征时，由于血液中初始药物浓度的增加而引起副作用，药物的皮肤渗透作用优异。

    Transdermal Preparations Containing Hydrophoic Non-Steroidal Anti-Inflammatory Drugs
    9.
    发明申请
    Transdermal Preparations Containing Hydrophoic Non-Steroidal Anti-Inflammatory Drugs 有权
    含有疏水性非甾体抗炎药的透皮制剂

    公开(公告)号：US20090252782A1

    公开(公告)日：2009-10-08

    申请号：US12084014

    申请日：2006-10-23

    申请人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

    发明人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7061 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196

    摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

    摘要翻译： 公开了含有疏水性药物的透皮制剂。 作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低 即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。 在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。 亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

    Sustained-Released Pellet Formulation of Alpha1-Receptor Antagonist and Process For the Preparation Thereof
    10.
    发明申请
    Sustained-Released Pellet Formulation of Alpha1-Receptor Antagonist and Process For the Preparation Thereof 审中-公开
    α1受体拮抗剂的持续释放丸剂制剂及其制备方法

    公开(公告)号：US20080226738A1

    公开(公告)日：2008-09-18

    申请号：US12064174

    申请日：2006-08-11

    申请人： Kwang Hyun Shin ,  Young Hee Shin ,  Sung Ah Bin ,  Jung Ju Kim

    发明人： Kwang Hyun Shin ,  Young Hee Shin ,  Sung Ah Bin ,  Jung Ju Kim

    IPC分类号： A61K9/52 ,  A61P35/00 ,  A61P43/00 ,  A61P13/08

    CPC分类号： A61K9/5026 ,  A61K9/1652 ,  A61K31/18 ,  A61K31/505

    摘要： A sustained-release pellet formulation comprising: a pellet core comprising an α1-receptor antagonist, a pellet-forming substance and a pharmaceutically acceptable excipient and a coating layer comprising an enteric coating substance and a water-insoluble polymer, which is coated on said pellet core maintains a therapeutically effective drug level in the blood for a sufficient time without an initial burst and sustains the release of the drug even in the small intestine due to the water-insoluble polymer in the coating layer

    摘要翻译： 一种持续释放丸剂制剂，其包括：包含α1-受体拮抗剂，颗粒形成物质和药学上可接受的赋形剂的丸粒核心和包含肠溶衣物质和水不溶性聚合物的涂层，其涂覆在所述丸粒 核心在血液中维持治疗有效的药物水平足够的时间而没有初始爆发，并且由于涂层中的水不溶性聚合物，甚至在小肠中也能维持药物的释放