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1.发明申请公开(公告)号：US20110263726A1
公开(公告)日：2011-10-27
申请号：US13087798
申请日：2011-04-15
申请人： Juntao Liu , Siqin Li , Linna Zhang , Lei Li , Jun Kuai
发明人： Juntao Liu , Siqin Li , Linna Zhang , Lei Li , Jun Kuai
IPC分类号： C07C27/00
摘要： A process for selective oxidative dehydrogenation of a hydrogen-containing CO mixed gas, comprising contacting a hydrogen-containing CO mixed gas raw material with at least one catalyst entity having an increased activity gradient disposed in a reactor under at least one reaction condition chosen from a reaction temperature ranging from 100 to 300° C., a volume space velocity ranging from 100 to 10000 h−1, and a reaction pressure ranging from −0.08 to 5.0 MPa, wherein the molar ratio of oxygen to hydrogen in the raw material ranges from 0.5:1 to 5:1.
摘要翻译： 一种用于含氢CO混合气体的选择性氧化脱氢的方法，包括使含氢CO混合气体原料与设置在反应器中的活化梯度增加的至少一个催化剂实体在至少一个反应条件下接触，所述反应条件选自 反应温度为100〜300℃，体积空间速度为100〜10000h -1，反应压力为-0.08〜5.0MPa，原料中氧与氢的摩尔比为 0.5：1至5：1。
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2.发明授权公开(公告)号：US08574522B2
公开(公告)日：2013-11-05
申请号：US13087798
申请日：2011-04-15
申请人： Juntao Liu , Siqin Li , Linna Zhang , Lei Li , Jun Kuai
发明人： Juntao Liu , Siqin Li , Linna Zhang , Lei Li , Jun Kuai
摘要： A process for selective oxidative dehydrogenation of a hydrogen-containing CO mixed gas, comprising contacting a hydrogen-containing CO mixed gas raw material with at least one catalyst entity having an increased activity gradient disposed in a reactor under at least one reaction condition chosen from a reaction temperature ranging from 100 to 300° C., a volume space velocity ranging from 100 to 10000 h−1, and a reaction pressure ranging from −0.08 to 5.0 MPa, wherein the molar ratio of oxygen to hydrogen in the raw material ranges from 0.5:1 to 5:1.
摘要翻译： 一种用于含氢CO混合气体的选择性氧化脱氢的方法，包括使含氢CO混合气体原料与设置在反应器中的活化梯度增加的至少一个催化剂实体在至少一个反应条件下接触，所述反应条件选自 反应温度为100〜300℃，体积空间速度为100〜10000h -1，反应压力为-0.08〜5.0MPa，原料中氧与氢的摩尔比为 0.5：1至5：1。
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3.发明授权Method for selective hydrogenation of phenylacetylene using composite bed in the presence of styrene 有权在苯乙烯存在下使用复合床选择性氢化苯乙炔的方法公开(公告)号：US08916736B2
公开(公告)日：2014-12-23
申请号：US13140645
申请日：2009-12-17
申请人： Siqin Li , Juntao Liu , Zhiyan Zhu , Junhua Zhu , Jun Kuai
发明人： Siqin Li , Juntao Liu , Zhiyan Zhu , Junhua Zhu , Jun Kuai
摘要： The present invention discloses a process for the selective hydrogenation of phenylacetylene in the presence of styrene conducted in a combined bed, which process comprises under hydrogenation reaction conditions, passing a hydrocarbon fraction feedstock containing phenylacetylene and styrene through a combined bed reactor containing a catalyst A and a catalyst B to contact the feedstock with the catalyst A and the catalyst B in turn, wherein the catalyst A is a nickel-based catalyst, the catalyst B is at least one selected from the group consisting of palladium-based catalysts and copper-based catalysts, and a weight ratio of the catalyst A loaded to the catalyst B loaded is from 0.5:1 to 5:1.
摘要翻译： 本发明公开了在合并床中进行苯乙烯选择性氢化的方法，该方法包括在氢化反应条件下，将含有苯基乙炔和苯乙烯的烃馏分原料通过含有催化剂A和 依次将原料与催化剂A和催化剂B接触的催化剂B，其中催化剂A是镍基催化剂，催化剂B是选自钯基催化剂和铜基催化剂中的至少一种 催化剂，负载催化剂B的催化剂A的重量比为0.5:1〜5:1。
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4.发明申请METHOD FOR SELECTIVE HYDROGENATION OF PHENYLACETYLENE USING COMPOSITE BED IN THE PRESENCE OF STYRENE 有权苯乙烯存在下使用复合床选择性加氢苯乙烯的方法公开(公告)号：US20110319684A1
公开(公告)日：2011-12-29
申请号：US13140645
申请日：2009-12-17
申请人： Siqin Li , Juntao Jiu , Zhiyan Zhu , Junhua Zhu , Jun Kuai
发明人： Siqin Li , Juntao Jiu , Zhiyan Zhu , Junhua Zhu , Jun Kuai
IPC分类号： C07C5/11
摘要： The present invention discloses a process for the selective hydrogenation of phenylacetylene in the presence of styrene conducted in a combined bed, which process comprises under hydrogenation reaction conditions, passing a hydrocarbon fraction feedstock containing phenylacetylene and styrene through a combined bed reactor containing a catalyst A and a catalyst B to contact the feedstock with the catalyst A and the catalyst B in turn, wherein the catalyst A is a nickel-based catalyst, the catalyst B is at least one selected from the group consisting of palladium-based catalysts and copper-based catalysts, and a weight ratio of the catalyst A loaded to the catalyst B loaded is from 0.5:1 to 5:1.
摘要翻译： 本发明公开了在合并床中进行苯乙烯选择性氢化的方法，该方法包括在氢化反应条件下，将含有苯基乙炔和苯乙烯的烃馏分原料通过含有催化剂A和 依次将原料与催化剂A和催化剂B接触的催化剂B，其中催化剂A是镍基催化剂，催化剂B是选自钯基催化剂和铜基催化剂中的至少一种 催化剂，负载催化剂B的催化剂A的重量比为0.5:1〜5:1。
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5.发明申请METHOD FOR PRODUCING ETHYLENE GLYCOL FROM OXALATE THROUGH THE FLUIDIZED BED CATALYTIC REACTION 有权通过流化床催化反应从氧化铝生产乙烯甘油的方法公开(公告)号：US20130331617A1
公开(公告)日：2013-12-12
申请号：US14000876
申请日：2012-02-24
申请人： Weimin Yang , Juntao Liu , Wanmin Wang , Jun Kuai
发明人： Weimin Yang , Juntao Liu , Wanmin Wang , Jun Kuai
IPC分类号： C07C29/149
CPC分类号： C07C29/149 , B01J23/83 , B01J23/84 , B01J23/8437 , B01J23/888 , B01J29/48 , Y02P20/52 , C07C31/202
摘要： A process for producing ethylene glycol includes contacting an oxalate with a fluidized bed catalyst under the following conditions: a reaction temperature of from about 170 to about 270° C., a weight space velocity of oxalate of from about 0.2 to about 7 hours−1, a hydrogen/ester molar ratio of about 20˜200:1, a reaction pressure of from about 1.5 to about 10 MPa, and a reaction temperature difference T of from about 1 to about 15° C. The fluidized bed catalyst includes: a) from about 5 to about 80 parts by weight of copper and the oxide thereof, b) from about 10 to about 90 parts by weight of at least one carrier selected from silica, molecular sieve or alumina, c) from about 0.01 to about 30 parts by weight of bismuth and tungsten metallic elements or the oxides thereof, or cerium and niobium metallic elements or the oxides thereof.
摘要翻译： 制备乙二醇的方法包括在以下条件下使草酸盐与流化床催化剂接触：反应温度为约170至约270℃，草酸的重量空间速度为约0.2至约7小时-1 氢/酯摩尔比为约20〜200:1，反应压力为约1.5〜10MPa，反应温度差T为约1〜约15℃。流化床催化剂包括： ）约5至约80重量份的铜及其氧化物，b）约10至约90重量份的至少一种选自二氧化硅，分子筛或氧化铝的载体，c）约0.01至约30 铋和钨金属元素或其氧化物或铈和铌金属元素或其氧化物的重量份。
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公开(公告)号：US20130197265A1
公开(公告)日：2013-08-01
申请号：US13641457
申请日：2011-04-13
申请人： Juntao Liu , Fengxia Sun , Jun Kuai
发明人： Juntao Liu , Fengxia Sun , Jun Kuai
IPC分类号： C07C67/18
CPC分类号： C07C67/18 , B01J21/04 , B01J21/063 , B01J23/6562 , B01J23/8926 , B01J23/894 , B01J23/8946 , B01J23/8973 , C07C67/36 , C07C69/38
摘要： The present invention relates to a process of producing oxalate by CO gas phase method for chiefly solving the technical problem of the low utilization efficiency of nitrogen oxides or nitrous acid esters in the prior art. The present invention solves the problem in a better way by using the following steps including: a gas phase stream V containing NO and methanol and oxygen enter a supergravity rotating bed reactor II and are subjected to the oxidative esterification reaction to produce an effluent VI containing methyl nitrite; a methyl nitrite effluent VII obtained from separating said effluent VI together with a CO gas II enter a coupling reactor II and is contacted with a catalyst II to react to form a dimethyl oxalate effluent VIII and a gas phase effluent IX containing NO; the resultant dimethyl oxalate effluent VIII is separated to obtain a dimethyl oxalate product I; optionally, the gas phase effluent IX containing NO is returned to the step above so as to be mixed with the gas phase stream V containing NO for being recycled. Therefore, the process is applicable to the industrial production of oxalate by CO gas phase method.
摘要翻译： 本发明涉及一种通过CO气相法生产草酸盐的方法，主要解决现有技术中氮氧化物或亚硝酸酯利用率低的技术问题。 本发明通过使用以下步骤更好地解决了该问题，包括：含有NO和甲醇和氧的气相流V进入超重力旋转床反应器II，并进行氧化酯化反应以产生含有甲基 亚硝酸盐 通过将CO 2气体II与所述流出物VI分离而获得的亚硝酸甲酯流出物VII进入偶联反应器II，并与催化剂II接触以进行反应以形成草酸二乙酯流出物VIII和含有NO的气相流出物IX; 将得到的草酸二甲酯流出物VIII分离得到草酸二甲酯产物I; 任选地，将含有NO的气相流出物IX返回到上述步骤，以与含有NO的气相物流V混合以进行再循环。 因此，该方法适用于CO气相法工业生产草酸盐。
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7.发明授权Method for producing ethylene glycol from oxalate through the fluidized bed catalytic reaction 有权通过流化床催化反应从草酸生产乙二醇的方法公开(公告)号：US09102583B2
公开(公告)日：2015-08-11
申请号：US14000876
申请日：2012-02-24
申请人： Weimin Yang , Juntao Liu , Wanmin Wang , Jun Kuai
发明人： Weimin Yang , Juntao Liu , Wanmin Wang , Jun Kuai
IPC分类号： C07C27/04 , C07C29/149 , B01J23/83 , B01J23/84 , B01J23/843 , B01J23/888 , B01J29/48
CPC分类号： C07C29/149 , B01J23/83 , B01J23/84 , B01J23/8437 , B01J23/888 , B01J29/48 , Y02P20/52 , C07C31/202
摘要： A process for producing ethylene glycol includes contacting an oxalate with a fluidized bed catalyst under the following conditions: a reaction temperature of from about 170 to about 270° C., a weight space velocity of oxalate of from about 0.2 to about 7 hours−1, a hydrogen/ester molar ratio of about 20˜200:1, a reaction pressure of from about 1.5 to about 10 MPa, and a reaction temperature difference T of from about 1 to about 15° C. The fluidized bed catalyst includes: a) from about 5 to about 80 parts by weight of copper and the oxide thereof, b) from about 10 to about 90 parts by weight of at least one carrier selected from silica, molecular sieve or alumina, c) from about 0.01 to about 30 parts by weight of bismuth and tungsten metallic elements or the oxides thereof, or cerium and niobium metallic elements or the oxides thereof.
摘要翻译： 制备乙二醇的方法包括在以下条件下使草酸盐与流化床催化剂接触：反应温度为约170至约270℃，草酸的重量空间速度为约0.2至约7小时-1 氢/酯摩尔比为约20〜200:1，反应压力为约1.5〜约10MPa，反应温度差T为约1〜约15℃。流化床催化剂包括： ）约5至约80重量份的铜及其氧化物，b）约10至约90重量份的至少一种选自二氧化硅，分子筛或氧化铝的载体，c）约0.01至约30 铋和钨金属元素或其氧化物或铈和铌金属元素或其氧化物的重量份。
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公开(公告)号：US08871968B2
公开(公告)日：2014-10-28
申请号：US13641457
申请日：2011-04-13
申请人： Juntao Liu , Fengxia Sun , Jun Kuai
发明人： Juntao Liu , Fengxia Sun , Jun Kuai
CPC分类号： C07C67/18 , B01J21/04 , B01J21/063 , B01J23/6562 , B01J23/8926 , B01J23/894 , B01J23/8946 , B01J23/8973 , C07C67/36 , C07C69/38
摘要： The present invention relates to a process of producing oxalate by CO gas phase method for chiefly solving the technical problem of the low utilization efficiency of nitrogen oxides or nitrous acid esters in the prior art. The present invention solves the problem in a better way by using the following steps including: a gas phase stream V containing NO and methanol and oxygen enter a supergravity rotating bed reactor II and are subjected to the oxidative esterification reaction to produce an effluent VI containing methyl nitrite; a methyl nitrite effluent VII obtained from separating said effluent VI together with a CO gas II enter a coupling reactor II and is contacted with a catalyst II to react to form a dimethyl oxalate effluent VIII and a gas phase effluent IX containing NO; the resultant dimethyl oxalate effluent VIII is separated to obtain a dimethyl oxalate product I; optionally, the gas phase effluent IX containing NO is returned to the step above so as to be mixed with the gas phase stream V containing NO for being recycled. Therefore, the process is applicable to the industrial production of oxalate by CO gas phase method.
摘要翻译： 本发明涉及一种通过CO气相法生产草酸盐的方法，主要解决现有技术中氮氧化物或亚硝酸酯利用率低的技术问题。 本发明通过使用以下步骤更好地解决了该问题，包括：含有NO和甲醇和氧的气相流V进入超重力旋转床反应器II，并进行氧化酯化反应以产生含有甲基 亚硝酸盐 通过将CO 2气体II与所述流出物VI分离而获得的亚硝酸甲酯流出物VII进入偶联反应器II，并与催化剂II接触以进行反应以形成草酸二乙酯流出物VIII和含有NO的气相流出物IX; 将得到的草酸二甲酯流出物VIII分离得到草酸二甲酯产物I; 任选地，将含有NO的气相流出物IX返回到上述步骤，以与含有NO的气相物流V混合以进行再循环。 因此，该方法适用于CO气相法工业生产草酸盐。
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公开(公告)号：US20080248460A1
公开(公告)日：2008-10-09
申请号：US11825385
申请日：2007-07-06
申请人： Jun Kuai , Joseph L. Wooters , Elliott Nickbarg , Yongchang Qiu , Lih-Ling Lin
发明人： Jun Kuai , Joseph L. Wooters , Elliott Nickbarg , Yongchang Qiu , Lih-Ling Lin
IPC分类号： C12Q1/70 , C12Q1/02 , C12Q1/68 , G01N33/573
CPC分类号： G01N33/6863 , C07K14/7151 , G01N33/57492 , G01N2333/525 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LTβR) modulators, which activate or inhibit LTβR signaling. LTβR modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LTβR complex proteins that act as LTβR activating or inhibiting agents. This invention also relates to the use of soluble molecules, directed against either the LTβR, its ligands, LIGHT and LTβ1α2, or its intracellular binding partners, that function to regulate LTβR signaling. A novel screening method for selecting soluble receptors, antibodies and other agents that modulate LTβR signaling is provided.
摘要翻译： 本发明涉及包含激活或抑制LTbetaR信号传导的淋巴毒素-β受体（LTbetaR）调节剂的组合物和方法。 LTbetaR调节剂可用于治疗淋巴细胞介导的免疫疾病和癌症，更具体地，用于调节线粒体介导的细胞凋亡。 本发明涉及用作LTbetaR活化或抑制剂的LTbetaR复合蛋白的可溶形式。 本发明还涉及用于调节LTbetaR信号传导的功能的LTbetaR，其配体LIGHT和LTbeta1alpha2或其胞内结合配偶体的可溶性分子的用途。 提供了一种新的筛选方法，用于选择调节LTbetaR信号传导的可溶性受体，抗体和其他试剂。
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公开(公告)号：US20060078944A1
公开(公告)日：2006-04-13
申请号：US10523328
申请日：2003-08-01
申请人： Jun Kuai , Lih-Ling Lin , Joseph Wooters , Elliott Nickbarg
发明人： Jun Kuai , Lih-Ling Lin , Joseph Wooters , Elliott Nickbarg
IPC分类号： G01N33/53 , C12P21/02 , C12N9/12 , C07K14/535 , C07K14/715
CPC分类号： C40B30/04 , A61K38/00 , C07K14/525 , C07K14/7151 , C07K19/00 , C07K2319/00
摘要： The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-α) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-κB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity of the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-α related diseases.
摘要翻译： 本发明尤其涉及包括肿瘤坏死因子α（TNF-α）和/或肿瘤坏死因子α受体（TNFR）的蛋白质复合物。 优选地，复合物包含至少一种选自以下的多肽：NF-κB激活激酶（NAK），RasGAP3，TRCP1和TRCP2。 本发明进一步提供鉴定用于调节复合物的稳定性和活性的化合物的测定。 还提供了调节凋亡和炎症以及治疗TNF-α相关疾病的方法。
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