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    Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins
    2.
    发明授权
    Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins 有权
    由具有高亲和性ELR-CXC趋化因子受体蛋白的细胞诱导的疾病的拮抗剂

    公开(公告)号：US08536116B2

    公开(公告)日：2013-09-17

    申请号：US13494587

    申请日：2012-06-12

    申请人： Jya-Wei Cheng ,  Kuo-Chun Huang ,  Hsi-Tsung Cheng ,  Hui-Yuan Yu

    发明人： Jya-Wei Cheng ,  Kuo-Chun Huang ,  Hsi-Tsung Cheng ,  Hui-Yuan Yu

    IPC分类号： A61K38/00

    CPC分类号： C07K14/521 ,  A61K38/19 ,  Y02A50/411

    摘要： Enclosed is an antagonist, which includes a peptide chain represented by an amino acid sequence. The amino acid sequence has a short sequence, C-X1X2X3X4X5-N, which is situated before and neighbored to the third cysteine (Cys, C) of the N-terminus, wherein X1 is an amino acid with aromatic ring, hydrophobic property or long chain, and X2, X3, X4 and X5 are glutamine (G), serine (S), alanine (A) and proline (P) respectively. In one embodiment, X1 is phenylalanine (F). The present antagonists can be used to inhibit or treat with the diseases caused by the activated cells expressing CXCR1 and/or CXCR2 receptor, for example, the acute or chronic inflammatory reaction induced with polymorphonuclear neutrophils (PMNs) expressing CXCR1 and/or CXCR2 receptor, and angiogenesis accompanied by tumor growth inhibition.

    摘要翻译： 封闭的是拮抗剂，其包括由氨基酸序列表示的肽链。 氨基酸序列具有短序列C-X1X2X3X4X5-N，其位于N-末端的第三半胱氨酸（Cys，C）之前并邻近，其中X1是具有芳环的氨基酸，疏水性或长 链，X2，X3，X4和X5分别是谷氨酰胺（G），丝氨酸（S），丙氨酸（A）和脯氨酸（P）。 在一个实施方案中，X 1是苯丙氨酸（F）。 本发明的拮抗剂可用于抑制或治疗由表达CXCR1和/或CXCR2受体的活化细胞引起的疾病，例如由表达CXCR1和/或CXCR2受体的多形核嗜中性粒细胞（PMN）诱导的急性或慢性炎症反应， 和伴有肿瘤生长抑制的血管发生。

    HIGH SALT-RESISTANCE ANTIBACTERIAL PEPTIDE AND METHOD FOR PRODUCING THE SAME
    3.
    发明申请
    HIGH SALT-RESISTANCE ANTIBACTERIAL PEPTIDE AND METHOD FOR PRODUCING THE SAME 有权
    高耐盐性抗菌肽及其生产方法

    公开(公告)号：US20130109834A1

    公开(公告)日：2013-05-02

    申请号：US13471688

    申请日：2012-05-15

    申请人： Jya-Wei CHENG ,  Hui-Yuan Yu ,  Hsi-Tsung Cheng ,  Kuo-Chun Huang

    发明人： Jya-Wei CHENG ,  Hui-Yuan Yu ,  Hsi-Tsung Cheng ,  Kuo-Chun Huang

    IPC分类号： C07K7/08

    CPC分类号： C07K7/08

    摘要： The present invention is related to a high salt-resistance antibacterial peptide by increasing width of side chain of amino acids and/or increasing length of side chain of amino acids in the antibacterial peptide; and a method for increasing salt-resistance of antibacterial peptide by increasing width of side chain and/or increasing length of side chain in the antibacterial peptide.

    摘要翻译： 本发明通过增加抗菌肽中氨基酸侧链的宽度和/或增加氨基酸侧链的长度而涉及高耐盐性抗菌肽; 以及通过增加抗菌肽侧链宽度和/或增加侧链长度来提高抗菌肽耐盐性的方法。

    Low hemolytic antimicrobial peptide, pharmaceutical composition and use thereof
    5.
    发明授权
    Low hemolytic antimicrobial peptide, pharmaceutical composition and use thereof 有权
    低溶血性抗菌肽，药物组合物及其用途

    公开(公告)号：US09090655B2

    公开(公告)日：2015-07-28

    申请号：US13074864

    申请日：2011-03-29

    申请人： Jya-Wei Cheng ,  Kuo-Chun Huang ,  His-Tsu Cheng ,  Hui-Yuan Yu

    发明人： Jya-Wei Cheng ,  Kuo-Chun Huang ,  His-Tsu Cheng ,  Hui-Yuan Yu

    IPC分类号： A61K38/12 ,  C07K7/08 ,  C07K7/64 ,  A61P33/02 ,  A61K38/08 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07K7/06 ,  A61K38/10 ,  C07K14/47 ,  A61K38/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/4723

    摘要： Disclosed is an antimicrobial peptide having an amino acid sequence of formula presented as (P1)M(nA1X1X2)N(P2)X, wherein P1 is selected from the group consisting of basic amino acids including Arg and Lys; A1 is selected from the group consisting of aromatic amino acids including Trp, Phe and Ala; X1 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; X2 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; P2 is selected from the group consisting of basic amino acids including Arg and Lys; and the numbers of M and X are respectively 0˜2; when N>2, A1 is Ala and the Ala residues are less than N−2.

    摘要翻译： 公开了具有式（P1）M（nA1X1X2）N（P2）X所示的式的氨基酸序列的抗微生物肽，其中P1选自包括Arg和Lys的碱性氨基酸; A1选自包括Trp，Phe和Ala的芳族氨基酸; X1选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; X2选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; P2选自包括Arg和Lys的碱性氨基酸; M和X的数目分别为0〜2; 当N> 2时，A1是Ala，Ala残基小于N-2。