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    Low hemolytic antimicrobial peptide, pharmaceutical composition and use thereof
    1.
    发明授权
    Low hemolytic antimicrobial peptide, pharmaceutical composition and use thereof 有权
    低溶血性抗菌肽，药物组合物及其用途

    公开(公告)号：US09090655B2

    公开(公告)日：2015-07-28

    申请号：US13074864

    申请日：2011-03-29

    Applicant: Jya-Wei Cheng ,  Kuo-Chun Huang ,  His-Tsu Cheng ,  Hui-Yuan Yu

    Inventor： Jya-Wei Cheng ,  Kuo-Chun Huang ,  His-Tsu Cheng ,  Hui-Yuan Yu

    IPC: A61K38/12 ,  C07K7/08 ,  C07K7/64 ,  A61P33/02 ,  A61K38/08 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07K7/06 ,  A61K38/10 ,  C07K14/47 ,  A61K38/00

    CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/4723

    Abstract: Disclosed is an antimicrobial peptide having an amino acid sequence of formula presented as (P1)M(nA1X1X2)N(P2)X, wherein P1 is selected from the group consisting of basic amino acids including Arg and Lys; A1 is selected from the group consisting of aromatic amino acids including Trp, Phe and Ala; X1 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; X2 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; P2 is selected from the group consisting of basic amino acids including Arg and Lys; and the numbers of M and X are respectively 0˜2; when N>2, A1 is Ala and the Ala residues are less than N−2.

    Abstract translation: 公开了具有式（P1）M（nA1X1X2）N（P2）X所示的式的氨基酸序列的抗微生物肽，其中P1选自包括Arg和Lys的碱性氨基酸; A1选自包括Trp，Phe和Ala的芳族氨基酸; X1选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; X2选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; P2选自包括Arg和Lys的碱性氨基酸; M和X的数目分别为0〜2; 当N> 2时，A1是Ala，Ala残基小于N-2。

    RETICLE HAVING A PROTECTION LAYER
    4.
    发明申请
    RETICLE HAVING A PROTECTION LAYER 审中-公开
    有保护层的物品

    公开(公告)号：US20070072090A1

    公开(公告)日：2007-03-29

    申请号：US11162913

    申请日：2005-09-28

    Applicant: Sheng-Yueh Chang ,  Te-Hung Wu ,  Kuo-Chun Huang

    Inventor： Sheng-Yueh Chang ,  Te-Hung Wu ,  Kuo-Chun Huang

    IPC: G03F1/14 ,  A47G1/12 ,  G03F1/00

    CPC classification number: G03F1/48 ,  G03F7/70983

    Abstract: A reticle includes a reticle body having a first surface, a pattern disposed on the first surface of the reticle body, and at least a protection layer disposed on the first surface of the reticle body. The protection layer is in contact with the first surface of the reticle body.

    Abstract translation: 标线片包括具有第一表面的刻线体，设置在标线本体的第一表面上的图案，以及至少设置在标线本体的第一表面上的保护层。 保护层与标线本体的第一表面接触。

    Method for improving illumination uniformity in exposure process, and exposure apparatus
    5.
    发明申请
    Method for improving illumination uniformity in exposure process, and exposure apparatus 审中-公开
    用于提高曝光处理中的照明均匀性的方法和曝光装置

    公开(公告)号：US20070024835A1

    公开(公告)日：2007-02-01

    申请号：US11195269

    申请日：2005-08-01

    Applicant: Kuo-Chun Huang ,  Benjamin Lin ,  Te-Hung Wu

    Inventor： Kuo-Chun Huang ,  Benjamin Lin ,  Te-Hung Wu

    IPC: G03B27/54

    CPC classification number: G03F7/70291 ,  G03F7/70191 ,  G03F7/70283 ,  G03F7/70308

    Abstract: A method for improving illumination uniformity in an exposure process is described, wherein a light source, a reticle and a projection system are used to expose a substrate in the exposure process. A realtime adjustable gray filter like a gray LCD panel is placed in the light path between the light source and the exposed substrate to compensate the illumination nonuniformity on the substrate in real time.

    Abstract translation: 描述了一种用于改善曝光过程中的照明均匀性的方法，其中在曝光过程中使用光源，掩模版和投影系统来曝光基板。 像灰色LCD面板这样的实时可调灰度滤光片被放置在光源和曝光的基板之间的光路中，以实时补偿基板上的照明不均匀性。

    METHOD FOR REDUCING CRITICAL DIMENSION
    6.
    发明申请
    METHOD FOR REDUCING CRITICAL DIMENSION 审中-公开
    降低关键尺寸的方法

    公开(公告)号：US20060257749A1

    公开(公告)日：2006-11-16

    申请号：US10908513

    申请日：2005-05-16

    Applicant: Sheng-Yueh Chang ,  Te-Hung Wu ,  Kuo-Chun Huang

    Inventor： Sheng-Yueh Chang ,  Te-Hung Wu ,  Kuo-Chun Huang

    IPC: G03F1/00 ,  G03C5/00

    CPC classification number: G03F7/2022 ,  G03F7/38

    Abstract: A method for reducing critical dimension is provided. An exposure process and a develop process are performed on a photoresist layer. An optical trim exposure process is performed between the exposure process and the development process or before the exposure process. The optical trim expsoure process is performed to expose the photoresit layer by using a fully open mask of which the transmission rate is greater than zero. Because of the performance of the optical trim exposure process, the critical dimension of the photoresist layer can be reduced without substantially changing the characteristics of the photoresist layer.

    Abstract translation: 提供了一种降低临界尺寸的方法。 在光致抗蚀剂层上进行曝光处理和显影处理。 在曝光处理和显影处理之间或曝光处理之前进行光学修整曝光处理。 通过使用传输速率大于零的完全打开的掩模来执行光学修整曝光处理以曝光光致掩膜层。 由于光学微调曝光工艺的性能，可以减少光致抗蚀剂层的临界尺寸而基本上不改变光致抗蚀剂层的特性。

    Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins
    7.
    发明授权
    Antagonists for diseases induced by cells with high-affinity ELR-CXC chemokine receptor proteins 有权
    由具有高亲和性ELR-CXC趋化因子受体蛋白的细胞诱导的疾病的拮抗剂

    公开(公告)号：US08536116B2

    公开(公告)日：2013-09-17

    申请号：US13494587

    申请日：2012-06-12

    Applicant: Jya-Wei Cheng ,  Kuo-Chun Huang ,  Hsi-Tsung Cheng ,  Hui-Yuan Yu

    Inventor： Jya-Wei Cheng ,  Kuo-Chun Huang ,  Hsi-Tsung Cheng ,  Hui-Yuan Yu

    IPC: A61K38/00

    CPC classification number: C07K14/521 ,  A61K38/19 ,  Y02A50/411

    Abstract: Enclosed is an antagonist, which includes a peptide chain represented by an amino acid sequence. The amino acid sequence has a short sequence, C-X1X2X3X4X5-N, which is situated before and neighbored to the third cysteine (Cys, C) of the N-terminus, wherein X1 is an amino acid with aromatic ring, hydrophobic property or long chain, and X2, X3, X4 and X5 are glutamine (G), serine (S), alanine (A) and proline (P) respectively. In one embodiment, X1 is phenylalanine (F). The present antagonists can be used to inhibit or treat with the diseases caused by the activated cells expressing CXCR1 and/or CXCR2 receptor, for example, the acute or chronic inflammatory reaction induced with polymorphonuclear neutrophils (PMNs) expressing CXCR1 and/or CXCR2 receptor, and angiogenesis accompanied by tumor growth inhibition.

    Abstract translation: 封闭的是拮抗剂，其包括由氨基酸序列表示的肽链。 氨基酸序列具有短序列C-X1X2X3X4X5-N，其位于N-末端的第三半胱氨酸（Cys，C）之前并邻近，其中X1是具有芳环的氨基酸，疏水性或长 链，X2，X3，X4和X5分别是谷氨酰胺（G），丝氨酸（S），丙氨酸（A）和脯氨酸（P）。 在一个实施方案中，X 1是苯丙氨酸（F）。 本发明的拮抗剂可用于抑制或治疗由表达CXCR1和/或CXCR2受体的活化细胞引起的疾病，例如由表达CXCR1和/或CXCR2受体的多形核嗜中性粒细胞（PMN）诱导的急性或慢性炎症反应， 和伴有肿瘤生长抑制的血管发生。

    AUDIO PROCESSING SYSTEM AND ADJUSTING METHOD FOR AUDIO SIGNAL BUFFER
    8.
    发明申请
    AUDIO PROCESSING SYSTEM AND ADJUSTING METHOD FOR AUDIO SIGNAL BUFFER 审中-公开
    音频处理系统和音频信号缓冲器的调整方法

    公开(公告)号：US20130108083A1

    公开(公告)日：2013-05-02

    申请号：US13616992

    申请日：2012-09-14

    Applicant: Kai-Ju Cheng ,  Ying-Jie Wang ,  Kuo-Chun Huang ,  Chih-Wei Tuan

    Inventor： Kai-Ju Cheng ,  Ying-Jie Wang ,  Kuo-Chun Huang ,  Chih-Wei Tuan

    IPC: H04R3/00

    CPC classification number: G11B20/10527 ,  G11B2020/10564 ,  G11B2020/10814 ,  H04N7/15 ,  H04R3/04 ,  H04R2410/00 ,  H04R2420/09

    Abstract: An audio processing system is provided. The audio processing system has a sound receiving device configured to receive sounds and output an audio signal; a controller, electrically connected to the sound receiving unit, configured to write the audio signal to an audio signal buffer with a first frequency; and an audio processing unit, electrically connected to the controller, configured to read the audio signal from the audio signal buffer with a second frequency to perform audio processing, wherein the controller further dynamically adjusts the second frequency, so that the second frequency approaches the first frequency according to a convergence curve.

    Abstract translation: 提供音频处理系统。 音频处理系统具有被配置为接收声音并输出音频信号的声音接收装置; 电连接到声音接收单元的控制器，被配置为将音频信号写入具有第一频率的音频信号缓冲器; 以及音频处理单元，电连接到所述控制器，被配置为以第二频率从所述音频信号缓冲器读取音频信号以执行音频处理，其中所述控制器进一步动态地调整所述第二频率，使得所述第二频率接近所述第一频率 频率根据收敛曲线。

    LOW HEMOLYTIC ANTIMICROBIAL PEPTIDE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    10.
    发明申请
    LOW HEMOLYTIC ANTIMICROBIAL PEPTIDE, PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权
    低毒性抗微生物肽，药物组合物及其用途

    公开(公告)号：US20110294724A1

    公开(公告)日：2011-12-01

    申请号：US13074864

    申请日：2011-03-29

    Applicant: Jya-Wei CHENG ,  Kuo-Chun HUANG ,  His-Tsu CHENG ,  Hui-Yuan YU

    Inventor： Jya-Wei CHENG ,  Kuo-Chun HUANG ,  His-Tsu CHENG ,  Hui-Yuan YU

    IPC: A61K38/12 ,  C07K7/08 ,  C07K7/64 ,  A61P33/02 ,  A61K38/08 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07K7/06 ,  A61K38/10

    CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/4723

    Abstract: Disclosed is an antimicrobial peptide having an amino acid sequence of formula presented as (P1)M(nA1X1X2)N(P2)X, wherein P1 is selected from the group consisting of basic amino acids including Arg and Lys; A1 is selected from the group consisting of aromatic amino acids including Trp, Phe and Ala; X1 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; X2 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; P2 is selected from the group consisting of basic amino acids including Arg and Lys; and the numbers of M and X are respectively 0˜2; when N>2, A1 is Ala and the Ala residues are less than N−2.

    Abstract translation: 公开了具有式（P1）M（nA1X1X2）N（P2）X所示的式的氨基酸序列的抗微生物肽，其中P1选自包括Arg和Lys的碱性氨基酸; A1选自包括Trp，Phe和Ala的芳族氨基酸; X1选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; X2选自碱性氨基酸或非极性氨基酸，包括Arg，Lys，Val，Leu，Ala和Ile; P2选自包括Arg和Lys的碱性氨基酸; M和X的数目分别为0〜2; 当N> 2时，A1是Ala，Ala残基小于N-2。

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