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1.发明授权Drug comprising as the active ingredient proliferative vector containing survivin promoter 有权包含含有存活蛋白启动子的活性成分增殖载体的药物公开(公告)号：US08142770B2
公开(公告)日：2012-03-27
申请号：US11569625
申请日：2005-05-23
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2710/10343 , C12N2830/00
摘要： It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active ingredient, a proliferative vector which contains a Survivin promoter proliferating depending on the expression of Survivin. This drug may be used in order to treat tumor. In this drug, use may be made of an adenovirus as the vector. In the adenovirus of this drug, an endogenous promoter of an E1A domain may be substituted with a Survivin promoter.
摘要翻译： 旨在提供用于基因治疗中的药物，其特异性靶向异常细胞如肿瘤细胞并且破坏其用于愈合。 即，作为活性成分的药物，其含有存活蛋白启动子的增殖载体，其依赖于存活蛋白的表达而增殖。 可以使用这种药物来治疗肿瘤。 在这种药物中，可以使用腺病毒作为载体。 在该药物的腺病毒中，E1A结构域的内源启动子可以用存活蛋白启动子取代。
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2.发明授权Drug comprising as the active ingredient proliferative vector containing survivin promoter 有权包含含有存活蛋白启动子的活性成分增殖载体的药物公开(公告)号：US08709812B2
公开(公告)日：2014-04-29
申请号：US13426048
申请日：2012-03-21
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2710/10343 , C12N2830/00
摘要： It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active ingredient, a proliferative vector which contains a Survivin promoter proliferating depending on the expression of Survivin. The drug may be used in order to treat tumor. In this drug, use may be made of an adenovirus as the vector. In the adenovirus of this drug, an endogenous promoter of an E1A domain may be substituted with a Survivin promoter.
摘要翻译： 旨在提供用于基因治疗中的药物，其特异性靶向异常细胞如肿瘤细胞并且破坏其用于愈合。 即，作为活性成分的药物，其含有存活蛋白启动子的增殖载体，其依赖于存活蛋白的表达而增殖。 可以使用该药物来治疗肿瘤。 在这种药物中，可以使用腺病毒作为载体。 在该药物的腺病毒中，E1A结构域的内源启动子可以用存活蛋白启动子取代。
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3.发明申请Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter 有权包含作为含有存活蛋白启动子的活性成分增殖载体的药物公开(公告)号：US20120230954A1
公开(公告)日：2012-09-13
申请号：US13426048
申请日：2012-03-21
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2710/10343 , C12N2830/00
摘要： It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active ingredient, a proliferative vector which contains a Survivin promoter proliferating depending on the expression of Survivin. The drug may be used in order to treat tumor. In this drug, use may be made of an adenovirus as the vector. In the adenovirus of this drug, an endogenous promoter of an E1A domain may be substituted with a Survivin promoter.
摘要翻译： 旨在提供用于基因治疗中的药物，其特异性靶向异常细胞如肿瘤细胞并且破坏其用于愈合。 即，作为活性成分的药物，其含有存活蛋白启动子的增殖载体，其依赖于存活蛋白的表达而增殖。 可以使用该药物来治疗肿瘤。 在这种药物中，可以使用腺病毒作为载体。 在该药物的腺病毒中，E1A结构域的内源启动子可以用存活蛋白启动子取代。
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4.发明申请Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter 有权包含作为含有存活蛋白启动子的活性成分增殖载体的药物公开(公告)号：US20090181907A1
公开(公告)日：2009-07-16
申请号：US11569625
申请日：2005-05-23
IPC分类号： A61K48/00 , C12N15/86 , A61K31/7052 , A61P35/00
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2710/10343 , C12N2830/00
摘要： It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active ingredient, a proliferative vector which contains a Survivin promoter proliferating depending on the expression of Survivin. This drug may be used in order to treat tumor. In this drug, use may be made of an adenovirus as the vector. In the adenovirus of this drug, an endogenous promoter of an E1A domain may be substituted with a Survivin promoter.
摘要翻译： 旨在提供用于基因治疗中的药物，其特异性靶向异常细胞如肿瘤细胞并且破坏其用于愈合。 即，作为活性成分的药物，其含有存活蛋白启动子的增殖载体，其依赖于存活蛋白的表达而增殖。 可以使用这种药物来治疗肿瘤。 在这种药物中，可以使用腺病毒作为载体。 在该药物的腺病毒中，E1A结构域的内源启动子可以用存活蛋白启动子取代。
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