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公开(公告)号：US10308609B2
公开(公告)日：2019-06-04
申请号：US14855102
申请日：2015-09-15
发明人： Kevin Duane Bunker , Chuangxing Guo , Mark Charles Grier , Chad Daniel Hopkins , Joseph Robert Pinchman , Deborah Helen Slee , Qinhua Huang , Mehmet Kahraman
IPC分类号： C07D213/89 , A61K31/164 , C07C233/14 , A61K31/27 , C07C233/05 , C07C271/14 , A61K31/13 , C07C211/38 , C07C233/58 , A61K31/444 , A61K45/06 , C07C317/30 , C07C215/42 , C07C233/06 , C07C233/09 , C07C233/13 , C07C233/23 , A61K31/145 , A61K31/16
摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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公开(公告)号：US20180042871A1
公开(公告)日：2018-02-15
申请号：US15633480
申请日：2017-06-26
发明人： Kevin Duane Bunker
IPC分类号： A61K31/16 , C07C217/52 , A61K45/06 , A61K31/24 , A61K31/221 , A61K9/00 , C07C233/63 , A61K31/133 , A61K31/14 , C07C211/62 , C07C233/41 , C07C233/52 , A61K31/13 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/235 , C07C233/23 , C07C235/74 , C07C233/06
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
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公开(公告)号：US20160355462A1
公开(公告)日：2016-12-08
申请号：US15239446
申请日：2016-08-17
发明人： Kevin Duane Bunker
IPC分类号： C07C233/06 , A61K31/16 , A61K31/221 , A61K9/00 , A61K31/24 , A61K31/216 , A61K45/06 , C07C233/23 , C07C217/52
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包含与胺连接的双环戊烷部分，化合物与阿片样镇痛药物的组合，以及通过施用化合物治疗疼痛或发热的方法。
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公开(公告)号：US09447025B2
公开(公告)日：2016-09-20
申请号：US14199567
申请日：2014-03-06
发明人： Kevin Duane Bunker
IPC分类号： C07C235/74 , C07C235/26 , C07C233/10 , C07C217/52 , A61K31/235 , A61K31/16 , A61K31/215 , C07C233/52 , A61K45/06 , C07C233/06 , C07C233/23 , A61K31/13 , A61K31/14 , A61K31/216 , A61K31/22 , C07C211/62 , C07C233/41
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
摘要翻译： 用于治疗疼痛或发热的止痛化合物，其包含与胺连接的双环戊烷部分，化合物与阿片样镇痛药物的组合，以及通过施用化合物治疗疼痛或发热的方法。
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公开(公告)号：US10513509B2
公开(公告)日：2019-12-24
申请号：US15603789
申请日：2017-05-24
发明人： Kevin Duane Bunker , Peter Qinhua Huang , Sunny Abraham , Joseph Robert Pinchman , Chad Daniel Hopkins , Deborah Helen Slee
IPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , A61K31/506 , A61P35/00
摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US10189780B2
公开(公告)日：2019-01-29
申请号：US15103038
申请日：2014-12-10
发明人： Kevin Duane Bunker
IPC分类号： C07C331/06 , C07C255/47 , C07C255/62 , C07C265/10 , C07C207/02 , C07C247/14 , C07C251/42 , C07C17/10 , B01J27/128 , B01J31/04 , B01J31/22 , B01J31/28 , C07C17/013 , C07C23/24 , C07C29/50 , C07C35/24 , C07C201/00 , C07C209/42 , C07C211/38 , C07C249/12 , C07C251/48 , C07C253/30 , C07C255/64 , C07C263/16
摘要： Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.
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公开(公告)号：US20180201614A1
公开(公告)日：2018-07-19
申请号：US15572744
申请日：2016-05-10
发明人： Kevin Duane Bunker , Sunny Abraham , Chad Daniel Hopkins , Joseph Robert Pinchman , Peter Qinhua Huang , Deborah Helen Slee
IPC分类号： C07D473/30 , C07D471/04 , C07D487/04 , A61P35/00
CPC分类号： C07D473/30 , A61P35/00 , C07D471/04 , C07D487/04
摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US09693975B2
公开(公告)日：2017-07-04
申请号：US15239446
申请日：2016-08-17
发明人： Kevin Duane Bunker
IPC分类号： C07C217/52 , C07C235/74 , C07C233/06 , C07C233/23 , C07C211/62 , C07C233/41 , C07C233/52 , C07C233/63 , A61K31/16 , A61K45/06 , A61K31/13 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/235 , A61K9/00 , A61K31/133 , A61K31/22 , A61K31/221 , A61K31/24
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0019 , A61K31/13 , A61K31/133 , A61K31/14 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/221 , A61K31/235 , A61K31/24 , A61K45/06 , C07C211/62 , C07C217/52 , C07C233/06 , C07C233/23 , C07C233/41 , C07C233/52 , C07C233/63 , C07C235/74 , C07C2602/38
摘要： Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
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公开(公告)号：US20160311766A1
公开(公告)日：2016-10-27
申请号：US15103038
申请日：2014-12-10
发明人： Kevin Duane Bunker
IPC分类号： C07C331/06 , C07C255/47 , C07C255/64 , C07C249/12 , C07C251/48 , C07C209/42 , C07C247/14 , C07C211/38 , C07C17/013 , C07C23/24 , C07C29/50 , C07C35/24 , C07C263/16 , C07C265/10 , C07C201/00 , C07C207/02 , B01J31/22 , B01J31/28 , B01J31/04 , B01J27/128 , C07C253/30
CPC分类号： C07C331/06 , B01J27/128 , B01J31/04 , B01J31/2217 , B01J31/28 , B01J2231/482 , B01J2531/007 , B01J2531/845 , C07C17/013 , C07C17/10 , C07C23/24 , C07C29/50 , C07C35/24 , C07C201/00 , C07C207/02 , C07C209/42 , C07C211/38 , C07C247/14 , C07C249/12 , C07C251/42 , C07C251/48 , C07C253/30 , C07C255/47 , C07C255/62 , C07C255/64 , C07C263/16 , C07C265/10 , C07C2602/38
摘要： Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.
摘要翻译： 本文公开了通式（I）的化合物，以及使用第VII族或第IX族过渡金属化合物合成取代的双环[1.1.1]戊烷的方法。
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公开(公告)号：US20160075654A1
公开(公告)日：2016-03-17
申请号：US14855102
申请日：2015-09-15
发明人： Kevin Duane Bunker , Chuangxing Guo , Mark Charles Grier , Chad Daniel Hopkins , Joseph Robert Pinchman , Deborah Helen Slee , Qinhua Huang , Mehmet Kahraman
IPC分类号： C07D213/89 , C07C233/05 , C07C233/14 , A61K31/27 , A61K45/06 , A61K31/13 , C07C211/38 , C07C233/58 , A61K31/444 , A61K31/164 , C07C271/14
CPC分类号： C07D213/89 , A61K31/13 , A61K31/145 , A61K31/16 , A61K31/164 , A61K31/27 , A61K31/444 , A61K45/06 , C07C211/38 , C07C215/42 , C07C233/05 , C07C233/06 , C07C233/09 , C07C233/13 , C07C233/14 , C07C233/23 , C07C317/30 , C07C2601/02 , C07C2602/38 , C07C2603/62 , A61K2300/00
摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
摘要翻译： 本文公开了式（I）和（II）的化合物，合成式（I）和（II）化合物的方法，以及使用式（I）和（II）化合物作为止痛剂的方法。
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