Abstract:
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, Ra is an alkyl group and X is a suitable leaving group. A compound has the formula: wherein Rf is a fluorous group, n is an integer between 0 and 6, m is 1, 2 or 3, Ra is an alkyl group and X is a leaving group.
Abstract:
1 Compounds of formula (I) in which where X is CH or N; Y is O; S, SnullO or NR5; Z is OR2, SR2, N(R3)R4; or Y and Z together form 5- to 7-membered ring which contains, 2 or 3 hetero atoms O and/or N and which is unsubstituted or substituted by C1-C4 alkyl, halo-C1-C4alkyl, halogen, nullO or cyclopropyl; V is a direct bond or C1-C6alkylene, which is unsubstituted or substituted by C1-C3alkyl, C2-C3alkylidene or C3-C6cycloalkyldiene, U is O, S, NR7, SO or SO2; W is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R1 is cyclopropyl; C1C6alkyl or halo-C1-C6alkyl; R2 and R3 independently of one another are C1-C6alkyl or halo-C1-C6alkyl, R4 and R5 independently of one another are hydrogen. C1-C6alkyl or C1-C6alkoxy: R7 is hydrogen, C1-C6alkyl, benzyl, C1-C6alkylcarbonyl, halo-C1-C6alkylcarbonyl, halo-C2-C6alkenylcarbonyl; R21 and R22 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy or C1C8alkylthio, R23, R24, R25, R26 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy; are pesticidally active. They can be used for pest control, in particular as fungicides, acaricides and insecticides in crop protection.
Abstract:
Compounds of the formula I in which: where: X is CH or N; Y is O; S, S═O or NR5; Z is OR2, SR2, N(R3)R4; or Y and Z together form 5- to 7-membered ring which contains, 2 or 3 hetero atoms O and/or N and which is unsubstituted or substituted by C1-C4alkyl, halo-C1-C4alkyl, halogen, ═O or cyclopropyl; V is a direct bond or C1-C6alkylene, which is unsubstituted or substituted by C1-C3alkyl, C2-C3alkylidene or C3-C6cycloalkylidene; U is O, S, NR7, SO or SO2; W is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R1 is cyclopropyl, C1C6alkyl or halo-C1-C6alkyl; R2 and R3 independently of one another are C1-C6alkyl or halo-C1-C6alkyl; R4 and R5 independently of one another are hydrogen, C1-C6alkyl or C1-C6alkoxy; R7 is hydrogen, C1-C6alkyl, benzyl, C1-C6alkylcarbonyl, halo-C1-C6alkylcarbonyl, halo-C2-C6alkenylcarbonyl; R21 and R22 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy or C1-C8alkylthio; R23, R24, R25, R26 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy; are pesticidally active. They can be used for pest control, in particular as fungicides, acaricides and insecticides in crop protection.
Abstract translation:式Iin的化合物,其中:其中:X为CH或N; Y为O; S,S = O或NR5; Z是OR2,SR2,N(R3)R4; 或Y和Z一起形成5-至7-元环,其含有2或3个杂原子O和/或N,并且其未被取代或被C 1 -C 4烷基,卤代-C 1 -C 4烷基,卤素,O或环丙基取代; V C 1 -C 3亚烷基或C 3 -C 6亚烷基; U是O,S,NR 7,SO或SO 2; W是取代或未取代的芳基或取代或未取代的杂芳基 R 1和R 2各自独立地为C 1 -C 6烷基或卤代-C 1 -C 6烷基; R 4和R 5彼此独立地为氢,C 1 -C 6烷基或C 1 -C 6烷氧基; R 7为 R 2和R 22彼此独立地是氢,卤素,C 1 -C 8烷基或C 1 -C 8烷氧基或C 1 -C 8烷硫基; R 23是氢,C 1 -C 6烷基,苄基,C 1 -C 6烷基羰基,卤代C 1 -C 6烷基羰基 R 24,R 25,R 26彼此独立地是氢,卤素,C 1 -C 8烷基或C 1 -C 8烷氧基; 具有杀虫活性,可用于防治害虫,特别是杀虫剂,杀螨剂和作物保护中的杀虫剂。
Abstract:
The invention relates to novel substituted heterocyclic compounds, to a plurality of processes for their preparation and to their use as fungicides, and to novel intermediates, to a plurality of processes for their preparation and to their use as fungicides.
Abstract:
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of mTOR pathway related diseases.
Abstract:
A carbonyl compound scavenger comprising a mineral acid salt of a benzylhydroxyamine-based compound of the formula (1) and at least one adsorbent selected from the group consisting of silica gel, alumina, cellulose and activated carbon: [wherein, R represents an alkyl group having 1 to 8 carbon atoms, haloalkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms, haloalkoxy group having 1 to 4 carbon atoms, nitro group or cyano group, and R1 and R2 represent each independently a hydrogen atom or alkyl group having 1 to 8 carbon atoms, and a hydrogen atom on a benzene ring to which a cyano group and R are connected may be substituted with an alkyl group having 1 to 8 carbon atoms, haloalkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms, haloalkoxy group having 1 to 4 carbon atoms, aryl group having 6 to 10 carbon atoms, nitro group or cyano group.].
Abstract translation:一种羰基化合物清除剂,其包含式(1)的苄基羟胺类化合物的无机酸盐和选自硅胶,氧化铝,纤维素和活性炭的至少一种吸附剂:[其中,R表示烷基 具有1至8个碳原子,具有1至4个碳原子的卤代烷基,具有1至4个碳原子的烷氧基,具有1至4个碳原子的卤代烷氧基,硝基或氰基,R 1, R 2和R 2各自独立地表示氢原子或碳原子数1〜8的烷基,氰基和R连接的苯环上的氢原子可以被烷基取代 具有1至8个碳原子,具有1至4个碳原子的卤代烷基,具有1至4个碳原子的烷氧基,具有1至4个碳原子的卤代烷氧基,具有6至10个碳原子的芳基,硝基或氰基] 。
Abstract:
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, Ra is an alkyl group and X is a suitable leaving group. A compound has the formula: wherein Rf is a fluorous group, n is an integer between 0 and 6, m is 1, 2 or 3, Ra is an alkyl group and X is a leaving group.
Abstract:
A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
Abstract translation:二苯基甲烷衍生物。 式(I)为新的(其中R 1和R 2各自为H,OH或低级烷氧基; U = -C XY或= NOW; X = H,CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3,-CONR 4 R 5,-CH 2 NHSO 2 -C 6 H 5或-C(R 8)= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H,低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O,S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13,-CH2-C(= NOR14)-CH2-COOR15,-CH (CN) - (CH 2)q -COOR 16或 - (CH 2)pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH,-SCN或衍生自5-或6-元环选择的单价gp,通过环中具有1个或更多个S的环; p = 1或2。
Abstract:
A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
Abstract translation:二苯基甲烷衍生物。 式(I)为新的(其中R 1和R 2各自为H,OH或低级烷氧基; U = -C XY或= NOW; X = H,CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3,-CONR 4 R 5,-CH 2 NHSO 2 -C 6 H 5或-C(R 8)= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H,低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O,S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13,-CH2-C(= NOR14)-CH2-COOR15,-CH (CN) - (CH 2)q -COOR 16或 - (CH 2)pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH,-SCN或衍生自5-或6-元环选择的单价gp,通过环中具有1个或更多个S的环; p = 1或2。