公开(公告)号：US12029748B2

公开(公告)日：2024-07-09

申请号：US16486220

申请日：2017-02-28

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay A. Peed ,  Paige N. Hollmaier ,  Rebecca A. Vongsa ,  David W. Koenig ,  Cheryce F. Joyner

IPC: A61K31/7068 ,  A61K31/198 ,  A61K45/06

CPC classification number: A61K31/7068 ,  A61K31/198 ,  A61K45/06

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally include a first therapeutic agent including α methyl-D glucoside and a second therapeutic agent including a nitrogen containing compound at a therapeutic amount. In some embodiments, the nitrogen containing compound can be, for example, L-Cysteine, Cytidine, D-Asparagine, Pyrimidine, D-Alanine, D-Glucosamine HCL, and N-Acetyl-D-Glucosamine.

公开(公告)号：US11166968B2

公开(公告)日：2021-11-09

申请号：US15758535

申请日：2015-09-29

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay Adrienne Peed ,  Cheryce Francina Joyner ,  Rebecca Ann Vongsa ,  David William Koenig ,  Ryan Daniel Bartell ,  Paige Nicole Hollmaier

IPC: A61K31/7004 ,  A61K31/194 ,  A61K31/7016 ,  A61K31/724 ,  A61K31/70 ,  A61P15/02 ,  A61K9/00 ,  A61K31/732 ,  A61K31/733

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally comprise a therapeutic amount of a first saccharide and a therapeutic amount of a second saccharide or an organic acid. The saccharides may be, for example, a pentose, a disaccharide, a cyclodextrin, a pectic substance or a non-digestible polysaccharide. The organic acid may be, for example, malic acid.

公开(公告)号：US20200009174A1

公开(公告)日：2020-01-09

申请号：US16486220

申请日：2017-02-28

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay A. Peed ,  Paige N. Hollmaier ,  Rebecca A. Vongsa ,  David W. Koenig ,  Cheryce F. Joyner

IPC: A61K31/7068 ,  A61K31/198

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally include a first therapeutic agent including α methyl-D glucoside and a second therapeutic agent including a nitrogen containing compound at a therapeutic amount. In some embodiments, the nitrogen containing compound can be, for example, L-Cysteine, Cytidine, D-Asparagine, Pyrimidine, D-Alanine, D-Glucosamine HCL, and N-Acetyl-D-Glucosamine.

公开(公告)号：US20220257622A1

公开(公告)日：2022-08-18

申请号：US17738286

申请日：2022-05-06

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Jingru Li ,  Lindsay Adrienne Peed ,  Cheryce Francina Joyner ,  Rebecca Ann Vongsa ,  David William Koenig ,  Ryan Daniel Bartell

IPC: A61K31/702 ,  A61K31/7016 ,  A61K31/719 ,  A61K31/7004 ,  A61K31/194 ,  A61K31/192 ,  A61K31/19 ,  A61K31/191 ,  A61P15/02 ,  A61K9/00 ,  A61K47/12

Abstract: The present invention provides compositions and formulations capable of maintaining or promoting the growth of certain strains of Lactobacilli spp. The compositions and formulations generally comprise only a single therapeutic agent selected from the group consisting of isomaltulose, maltitol, pullulan, maltotriose, 2-deoxy-D-ribose, 1-kestose and erlose. The single therapeutic agent is the sole source of carbon for bacterium when administered to a user. Despite comprising only a single therapeutic agent the compositions have been shown to promote the growth and maintenance of beneficial Lactobacilli and to effectively inhibit the growth of pathogens associated with urogenital infections. As such administration of the compositions maintain a healthy microflora balance in the urogenital area.

公开(公告)号：US20240307428A1

公开(公告)日：2024-09-19

申请号：US18673865

申请日：2024-05-24

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay A. Peed ,  Paige N. Hollmaier ,  Rebecca A. Vongsa ,  David W. Koenig ,  Cheryce F. Joyner

IPC: A61K31/7068 ,  A61K31/198 ,  A61K45/06

CPC classification number: A61K31/7068 ,  A61K31/198 ,  A61K45/06

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally include a first therapeutic agent including α methyl-D glucoside and a second therapeutic agent including a nitrogen containing compound at a therapeutic amount. In some embodiments, the nitrogen containing compound can be, for example, L-Cysteine, Cytidine, D-Asparagine, Pyrimidine, D-Alanine, D-Glucosamine HCL, and N-Acetyl-D-Glucosamine.

公开(公告)号：US20220023322A1

公开(公告)日：2022-01-27

申请号：US17496814

申请日：2021-10-08

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Jingru Li ,  Lindsay Adrienne Peed ,  Cheryce Francina Joyner ,  Rebecca Ann Vongsa ,  David William Koenig ,  Ryan Daniel Bartell ,  Paige Nicole Hollmaier

IPC: A61K31/7004 ,  A61K31/194 ,  A61K31/7016 ,  A61K31/724 ,  A61K31/70 ,  A61P15/02 ,  A61K9/00

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally comprise a therapeutic amount of a first saccharide and a therapeutic amount of a second saccharide or an organic acid. The saccharides may be, for example, a pentose, a disaccharide, a cyclodextrin, a pectic substance or a non-digestible polysaccharide. The organic acid may be, for example, malic acid.

公开(公告)号：US20180250318A1

公开(公告)日：2018-09-06

申请号：US15758535

申请日：2015-09-29

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Jingru Li ,  Lindsay Adrienne Peed ,  Cheryce Francina Joyner ,  Rebecca Ann Vongsa ,  David William Koenig ,  Ryan Daniel Bartell ,  Paige Nicole Hollmaier

IPC: A61K31/7004 ,  A61K31/7016 ,  A61K9/00 ,  A61P15/02

CPC classification number: A61K31/7004 ,  A61K9/0034 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/724 ,  A61K31/732 ,  A61K31/733 ,  A61K2300/00 ,  A61P15/02 ,  Y02A50/473

Abstract: The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally comprise a therapeutic amount of a first saccharide and a therapeutic amount of a second saccharide or an organic acid. The saccharides may be, for example, a pentose, a disaccharide, a cyclodextrin, a pectic substance or a non-digestible polysaccharide. The organic acid may be, for example, malic acid.