公开(公告)号：US09974749B2

公开(公告)日：2018-05-22

申请号：US14877916

申请日：2015-10-07

申请人： KING SAUD UNIVERSITY

发明人： Manal Ahmed Gasmelseed Awad ,  Awatif Ahmed Hendi ,  Mai Abdelrahman Elobeid Wagealla ,  Promy Virk ,  Khalid Mustafa Osman Ortashi

IPC分类号： A61P31/04 ,  A61K33/30 ,  A61P17/02 ,  A61K9/16 ,  A61K33/38 ,  A61K33/24

CPC分类号： A61K33/24 ,  A61K9/14 ,  A61K33/30 ,  A61K33/38 ,  A61L26/0066 ,  A61L2300/30 ,  A61L2300/624 ,  A61L2400/12

摘要： The method of treating diabetic wounds using biosynthesized nanoparticles includes administering an effective amount of silver and gold nanoparticles to a patient in need thereof. The silver and gold nanocomposite is prepared by ‘biosynthesis”, i.e., by providing a first aqueous solution of a noble metal salt or a noble metal oxide; providing a second solution of an aqueous plant extract, and combining the first solution and the second solution to produce a solution including nanoparticles of the noble metal. The second solution includes a plant extract obtained from Solenostemma argel, Trigonella foenum-graecum and Cinnamomum cassia. The metal salt can include silver nitrate (AgNO3) and chloroauric acid (HAuCl4). Nanoparticles of gold and nanoparticles of silver are prepared separately, and then mixed to obtain a composition containing a gold and silver nanocomposite.

公开(公告)号：US09700512B1

公开(公告)日：2017-07-11

申请号：US15151454

申请日：2016-05-10

申请人： KING SAUD UNIVERSITY

发明人： Mai Abdelrahman Elobeid Wagealla ,  Lulwah Saleh Mohammed Al-Hassan ,  Manal Ahmed Gasmelseed Awad ,  Nouf Abdullah Mureet Al-Ghamdi ,  Promy Virk ,  Awatif Ahmed Hendi

IPC分类号： A61K31/353 ,  A61K9/14

CPC分类号： A61K9/14 ,  A61K31/353

摘要： A method of preparing hesperetin nanoparticles includes dissolving hesperetin in an organic solvent to form a solution; spraying the solution in boiling water while applying ultrasonic energy to form a mixture; and stirring the mixture for at least about 15 minutes at a speed of about 200-800 rpm to obtain the hesperetin nanoparticles.

公开(公告)号：US09480656B1

公开(公告)日：2016-11-01

申请号：US14868351

申请日：2015-09-28

申请人： KING SAUD UNIVERSITY

发明人： Manal Ahmed Gasmelseed Awad ,  Awatif Ahmed Hendi ,  Promy Virk ,  Khalid Mustafa Osman Ortashi ,  Mai Abdelrahman Elobeid Wagealla

IPC分类号： A61K36/53 ,  A61K9/50

CPC分类号： A61K9/5073 ,  A61K9/14 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5089 ,  A61K9/5138 ,  A61K9/5146 ,  A61K36/53 ,  A61K2236/39

摘要： A method of preparing rosemary nanoparticles includes providing a solution including rosemary extract, spraying the rosemary extract solution into boiling water under ultrasonic conditions to produce a sonicated mixture, and freeze-drying the sonicated mixture to produce rosemary nanoparticles. The rosemary nanoparticles and encapsulated rosemary nanoparticles with polymers can have a particle size of about 69 nm to about 99 nm. The rosemary nanoparticles and encapsulated rosemary nanoparticles with polymers can be prepared without the use of metals.

摘要翻译： 制备迷迭香纳米颗粒的方法包括提供包括迷迭香提取物的溶液，在超声波条件下将迷迭香提取物溶液喷洒到沸水中以产生超声处理的混合物，并将超声处理的混合物冷冻干燥以产生迷迭香纳米颗粒。 具有聚合物的迷迭香纳米颗粒和包封的迷迭香纳米颗粒可以具有约69nm至约99nm的粒度。 具有聚合物的迷迭香纳米颗粒和包封的迷迭香纳米颗粒可以在不使用金属的情况下制备。

公开(公告)号：US09428399B1

公开(公告)日：2016-08-30

申请号：US14868358

申请日：2015-09-28

申请人： KING SAUD UNIVERSITY

发明人： Manal Ahmed Gasmelseed Awad ,  Awatif Ahmed Hendi ,  Mai Abdelrahman Elobeid Wagealla ,  Khalid Mustafa Osman Ortashi ,  Promy Virk

IPC分类号： C01G9/02 ,  A61K33/30 ,  A61K33/38 ,  A61K33/24 ,  C02F1/72 ,  B22F9/24 ,  B22F1/00 ,  C22B7/00 ,  C22B3/00 ,  C22B19/20 ,  C22B19/34 ,  C02F101/10 ,  C02F101/12

CPC分类号： C01G9/02 ,  A61K33/30 ,  A61K33/38 ,  B01J20/06 ,  B01J20/28007 ,  B01J20/28019 ,  B01J20/3085 ,  B22F1/0018 ,  B22F9/24 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/64 ,  C02F1/281 ,  C02F1/505 ,  C02F2101/10 ,  C02F2101/101 ,  C02F2101/12 ,  C02F2303/04 ,  C02F2305/08 ,  C22B11/04 ,  C22B19/20 ,  C22B19/34 ,  Y10S977/773

摘要： The synthesis of nanoparticles of metals and metal oxides using plant seeds extract involves providing a solution comprising a metal ion; providing a plant seeds extract solution that comprises a reducing agent; and combining the metal ion solution and the plant extract solution while stirring at room temperature to produce metal nanoparticles. The plant extract is obtained from Trigonella foenum-graecum seeds, and the metal ion is selected from the group consisting of silver (Ag), gold (Au) and zinc (Zn).

摘要翻译： 使用植物种子提取物合成金属和金属氧化物的纳米颗粒涉及提供包含金属离子的溶液; 提供包含还原剂的植物种子提取物溶液; 并在室温下搅拌的同时将金属离子溶液与植物提取物溶液混合，制成金属纳米粒子。 植物提取物获自三叶草（Trigonella foenum-graecum）种子，金属离子选自银（Ag），金（Au）和锌（Zn）。

公开(公告)号：US11617719B1

公开(公告)日：2023-04-04

申请号：US16988077

申请日：2020-08-07

申请人： KING SAUD UNIVERSITY

发明人： Manal Ahmed Gasmelseed Awad ,  Promy Virk ,  Mai Abdelrahman Elobeid Wagealla ,  Sarah Saleh Abdulla Alsaif ,  Awatif Ahmed Hendi ,  Khalid Mustafa Osman Ortashi ,  Rabia Qindeel

IPC分类号： A61K9/14 ,  A61K47/36 ,  A61P35/00 ,  A61K47/32 ,  A61P3/10 ,  A61K36/31

摘要： The Moringa oleifera nanoparticles may be synthesized by harvesting Moringa leaves, drying the Moringa leaves, powdering the dried Moringa leaves, suspending the powdered Moringa leaves in a solution, and spraying the solution into boiling water under ultrasonic conditions to obtain Moringa nanoparticles. The Moringa nanoparticles may be encapsulated by dissolving the Moringa nanoparticles and gum olibanum in ethanol to produce a mixture, injecting the inert organic phase of the mixture into an aqueous solution containing PVA, and homogenizing the aqueous solution. The Moringa nanoparticles may be useful in preventing the growth of cancer cells and in treating diabetes by inhibiting α-glucosidase and/or α-amylase activity.

公开(公告)号：US10363218B1

公开(公告)日：2019-07-30

申请号：US16239277

申请日：2019-01-03

申请人： KING SAUD UNIVERSITY

发明人： Promy Virk ,  Manal Ahmed Gasmelseed Awad ,  Amnah El-Enazy ,  Awatif Ahmed Hendi ,  Mai Abdelrahman Elobeid Wagealla ,  Rabia Qindeel

IPC分类号： A23L33/135 ,  A61K9/16 ,  A61P39/06 ,  A61K35/741

摘要： A method of preparing probiotic nanoparticles can include dissolving formulated probiotics in methanol, spraying the methanol solution into boiling water under ultrasonic conditions to provide a sonicated solution, and stirring the sonicated solution to obtain probiotic nanoparticles. The probiotic nanoparticles may be cluster or rod-shaped. The probiotic nanoparticles may be administered to a subject to reduce oxidative stress or to treat diseases associated with oxidative stress.

公开(公告)号：US09622984B1

公开(公告)日：2017-04-18

申请号：US15141781

申请日：2016-04-28

申请人： KING SAUD UNIVERSITY

发明人： Promy Virk ,  Nouf Abdallah Mureet Al-Ghamdi ,  Manal Ahmed Gasmelseed Awad ,  Mai Abdelrahman Elobeid Wagealla ,  Awatif Ahmed Hendi ,  Lulwah Saleh Mohammed Al Hassan

IPC分类号： A61K9/51 ,  A61K31/353

CPC分类号： A61K9/5192 ,  A23K20/111 ,  A23K50/80 ,  A61K9/14 ,  A61K31/353

摘要： A method of preparing naringenin nanoparticles comprises dissolving naringenin in an organic solvent to form a solution; adding the solution to boiling water under ultrasonic conditions to form a mixture; and stirring the mixture to obtain the naringenin nanoparticles. The organic solvent can be at least one of methanol, ethanol, dichloromethane and chloroform. Ultrasonic conditions can include applying ultrasonic energy at a frequency of 30-60 kHz and a power of 100 watts for about 20-30 minutes to the mixture.