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1.发明申请公开(公告)号：US20210318326A1
公开(公告)日：2021-10-14
申请号：US17266547
申请日：2019-04-19
Applicant: KONICA MINOLTA, INC.
Inventor： Takanori MURAYAMA
IPC: G01N33/58 , G01N33/543
Abstract: The present invention pertains to a BNP measuring method with which it is possible to measure the concentration of BNP in a specimen with higher sensitivity and higher reproducibility. A protease inhibitor is added to a specimen that contains brain natriuretic peptide to obtain a pretreatment specimen. The pretreatment specimen is provided on a metal film to which a binding substance capable of binding specifically. Either prior to or following the binding to the binding substance, the brain natriuretic peptide is labeled with a fluorescent substance. In a state where the brain natriuretic peptide labeled with the fluorescent substance is bound to the binding substance immobilized to the metal film, the metal film is irradiated with excitation light so as to cause surface plasmon resonance to occur in the metal film, and then fluorescence released from the fluorescent substance is detected.
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2.发明申请公开(公告)号：US20190039067A1
公开(公告)日：2019-02-07
申请号：US16074022
申请日：2016-02-02
Applicant: Konica Minolta, Inc.
Inventor： Youichi AOKI , Takanori MURAYAMA
Abstract: Aiming to provide a method capable of reciprocatingly delivering various liquids without bringing air into a microchannel, a detection system and a detection apparatus for implementation of this method. In order to achieve at least one of the above aims, provided is a method of inserting a pipette tip into a liquid injection portion of a detection chip including: the microchannel; the liquid injection portion connected to one end of the microchannel; and a reservoir connected to the other end of the microchannel, injecting and aspirating the liquid by the pipette tip, and reciprocatingly delivering the liquid into the microchannel. At this time, the following steps are executed in this order, the steps including: inserting the pipette tip into the liquid injection portion up to a position at which an end of the pipette tip comes below a liquid level when the liquid is injected into the liquid injection portion; injecting the liquid from the pipette tip into the liquid injection portion; generating a negative pressure in the liquid injection portion to raise the level of the liquid in the liquid injection portion; and performing either aspiration of the liquid in the liquid injection portion by the pipette tip, or injection of the liquid into the liquid injection portion by the pipette tip and aspiration of the liquid inside the liquid injection portion.
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公开(公告)号：US20160245803A1
公开(公告)日：2016-08-25
申请号：US15032261
申请日：2014-10-22
Applicant: KONICA MINOLTA, INC.
Inventor： Takanori MURAYAMA , Atsuo IWASHITA
IPC: G01N33/543 , G01N21/77 , G01N21/64
Abstract: An antigen detection method using sandwich immunoassay includes a first reaction step of preparing a sensor chip, which includes a fine flow channel in which a reaction zone having an antigen-capturing antibody immobilized thereon is arranged, a liquid discharge/suction section and a liquid-mixing section, and subsequently feeding thereto a sample liquid so as to allow the antigen-capturing antibody to capture a target; and a second reaction step of allowing a labeling liquid containing a labeling antibody to flow into the fine flow channel so as to label the target. In the antigen detection method, the labeling liquid does not reach the liquid-mixing section. According to the antigen detection method, the accuracy and the repeatability of the target measurement can be improved.
Abstract translation: 使用夹心免疫测定法的抗原检测方法包括制备传感器芯片的第一反应步骤，其包括其中布置有固定有抗原捕获抗体的反应区的细流动通道，液体排出/抽吸部分和液体 - 混合部分，然后向其中加入样品液体，以使抗原捕获抗体捕获靶标; 以及允许含有标记抗体的标记液体流入细流动通道以便标记靶的第二反应步骤。 在抗原检测方法中，标记液未到达液体混合部。 根据抗原检测方法，能够提高目标测定的精度和重复性。
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Patent Agency Ranking
公开(公告)号：US20210069716A1
公开(公告)日：2021-03-11
申请号：US16963428
申请日：2018-10-24
Applicant: Konica Minolta, Inc.
Inventor： Koji MIYAZAKI , Hideyuki FUJII , Ko OSAWA , Takanori MURAYAMA
Abstract: To provide a temperature adjustment stage that can efficiently heat a cartridge in accordance with necessity of heating each well. A temperature adjustment stage for heating a cartridge in which a plurality of wells that store a liquid are formed. The cartridge is used in an inspection system that detects an object captured by an immunoreaction, the wells include a labeled antibody well that stores a labeled antibody that labels the object, and there is provided a structure that does not heat the labeled antibody well.
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公开(公告)号：US20200256844A1
公开(公告)日：2020-08-13
申请号：US16466512
申请日：2017-12-04
Applicant: KONICA MINOLTA, INC.
Inventor： Masanao MAJIMA , Makiko OTANI , Masataka MATSUO , Takanori MURAYAMA
IPC: G01N33/487 , B01L3/00 , G01N33/49
Abstract: To provide an inspection cartridge capable of preventing a user from using a blood sample of a wrong vacuum blood collection tube when the user dispenses the blood sample from the vacuum blood collection tube to the inspection cartridge, and a blood inspection device which performs a blood inspection using the same. An inspection cartridge used for performing a blood inspection with a blood inspection device provided with an identifier for identifying an anticoagulant usable in the inspection cartridge.
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公开(公告)号：US20210025908A1
公开(公告)日：2021-01-28
申请号：US17045109
申请日：2019-03-29
Applicant: KONICA MINOLTA, INC.
Inventor： Kou OSAWA , Takanori MURAYAMA , Yuuya SHOUJI , Youichi AOKI , Hiroshi HIRAYAMA
Abstract: Temperature adjustment with a pipette tip temperature adjustment unit (7) and a drive unit (54) for raising and lowering a pipette tip (51), an environment temperature sensor (10) for sensing temperature inside an analysis apparatus (1A), a pump (53) for drawing a liquid into pipette tip (51) and discharging liquid in the pipette tip (51), and a control unit (6a) for setting, in advance, temperature control target value during sample analysis for unit (7) based on environment temperature sensed by sensor (10), and during sample analysis, drive unit (54) lowers pipette tip (51), pump (53) performs pumping wherein intake and discharge are repeated in a state in which unit (7) blows air, and unit (6a) sets, in advance, the temperature value for use during sample analysis for the pipette tip temperature adjustment unit (7) on the basis of analysis reagent information and the environment temperature sensed by e sensor (10).
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公开(公告)号：US20180292428A1
公开(公告)日：2018-10-11
申请号：US15762074
申请日：2016-10-26
Applicant: KONICA MINOLTA, INC.
Inventor： Takanori MURAYAMA , Youichi AOKI
IPC: G01N35/10 , G01N33/543
Abstract: A liquid delivery method according to the present invention performs a procedure including supplying a first liquid into a microchannel and collecting the first liquid from within the microchannel, and then, dispensing a first amount of a second liquid without hermetically sealing a pipette tip insertion hole, then, dispensing a second amount of the second liquid in a state where the pipette tip insertion hole is hermetically closed to supply the second liquid into the microchannel.
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公开(公告)号：US20170122965A1
公开(公告)日：2017-05-04
申请号：US15318538
申请日：2015-07-14
Applicant: Konica Minolta, Inc.
Inventor： Takanori MURAYAMA
IPC: G01N33/68 , G01N33/543 , G01N33/553 , G01N21/51 , G01N21/64
CPC classification number: G01N33/6887 , G01N21/05 , G01N21/51 , G01N21/553 , G01N21/6428 , G01N21/648 , G01N33/54306 , G01N33/54366 , G01N33/54373 , G01N33/553 , G01N2021/0346 , G01N2021/058 , G01N2333/4712
Abstract: In a first step, by moving a blocking liquid containing a blocking agent in a containing unit for containing a liquid, the inside of the containing unit is subjected to a blocking treatment. In a second step, by supplying a liquid containing a reaction target substance (detection target substance) into the containing unit, a reaction field which is exposed to the containing unit and to which a capturing body is fixed is caused to capture the reaction target substance. The second step is performed following the first step or simultaneously with the first step.
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