公开(公告)号：US20200271593A1

公开(公告)日：2020-08-27

申请号：US16645619

申请日：2018-06-22

Applicant: Konica Minolta, Inc.

Inventor： Tetsuya NODA ,  Masanao MAJIMA ,  Yuuya SHOUJI

IPC: G01N21/94 ,  G01N21/552 ,  G01N21/958 ,  G01N21/64

Abstract: An analysis method for detecting an amount of a substance by irradiating an analysis chip containing the substance and detecting a quantity of light output from the analysis chip. The analysis method including irradiating an incident surface of the analysis chip and another surface adjacent to the incident surface with detection light while changing a relative position of the detection light with respect to the analysis chip, detecting reflected light from the incident surface of the analysis chip, and acquiring information on a position of the analysis chip from a relationship between a quantity of the reflected light detected and the relative position. The analysis method determines if the analysis chip is abnormal when a quantity of target reflected light is equal to or lower than a predetermined light quantity.

公开(公告)号：US20200025784A1

公开(公告)日：2020-01-23

申请号：US16491381

申请日：2018-03-02

Applicant: KONICA MINOLTA, INC.

Inventor： Hiromi FUJII ,  Atsushi HOSOTANI ,  Yasuhiro MIYAKE ,  Takefumi ASOU ,  Tetsuya NODA ,  Atsuo IWASHITA ,  Yuuya SHOUJI

IPC: G01N35/10 ,  B01L3/02

Abstract: A pipette tip leading end detection device for detecting that a leading end of a pipette tip is close to a reference surface set to a reaction vessel includes a pipette nozzle, pump, nozzle driver, pressure sensor that detects a pressure generated between the pipette tip and pump, and hardware processor. The hardware processor obtains a determination value using an AD conversion value obtained from the pressure while the pipette nozzle is being lowered, and detects that the leading end of the pipette tip is close to the reference surface on the basis that the determination value is a threshold value or more. The determination value is a calculation value indicating a pressure change speed calculated from AD conversion values within a past certain time and the threshold value is a value larger than maximum noise.

公开(公告)号：US20200018775A1

公开(公告)日：2020-01-16

申请号：US16491373

申请日：2018-03-02

Applicant: KONICA MINOLTA, INC.

Inventor： Hiromi FUJII ,  Teiji TANAKA ,  Tatsuya YAMAZAKI ,  Tomoharu NAKAGAWA ,  Tetsuya NODA ,  Atsuo IWASHITA ,  Yuuya SHOUJI

IPC: G01N35/10

Abstract: Provided is a temperature control system applied to an apparatus for analyzing a sample using a pipette nozzle and a reaction container, including a pipette tip temperature controller that heats a pipette tip which is fitted on the pipette nozzle and aspirates or discharges liquid and a reaction container temperature controller that heats the reaction container. The pipette tip temperature controller heats, in a concentrated manner, at least a distal end portion of the pipette tip of the pipette nozzle located at a predetermined heating position with hot air emitted from a heat source and is configured such that a distal end is capable of arriving at the reaction container by lowering the pipette nozzle from the heating position.

公开(公告)号：US20180059130A1

公开(公告)日：2018-03-01

申请号：US15551757

申请日：2016-01-19

Applicant: Konica Minolta, Inc.

Inventor： Atsuo IWASHITA ,  Tetsuya NODA ,  Masataka MATSUO ,  Koji MIYAZAKI ,  Yuuya SHOUJI

IPC: G01N35/10 ,  B01L3/02 ,  G01N35/00

CPC classification number: G01N35/1011 ,  B01L3/0217 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2400/0487 ,  G01N35/00623 ,  G01N35/10 ,  G01N35/1016

Abstract: In a detection method, a first pressure within a pipette tip is measured when air is sucked into or expelled from the leading end of the pipette tip in a state where the leading end of the pipette tip and a reference part of a solid are separated. A second pressure within the pipette tip is measured when air is sucked into or expelled from the leading end of the pipette tip in a state where the leading end of the pipette tip and the reference part of the solid are closer than in the first step. After the first step and second step, the position of the leading end of the pipette tip in relation to the reference part is detected on the basis of the difference between the first pressure measured in the first step and the second pressure measured in the second step.

公开(公告)号：US20210025908A1

公开(公告)日：2021-01-28

申请号：US17045109

申请日：2019-03-29

Applicant: KONICA MINOLTA, INC.

Inventor： Kou OSAWA ,  Takanori MURAYAMA ,  Yuuya SHOUJI ,  Youichi AOKI ,  Hiroshi HIRAYAMA

IPC: G01N35/04 ,  B01L3/02

Abstract: Temperature adjustment with a pipette tip temperature adjustment unit (7) and a drive unit (54) for raising and lowering a pipette tip (51), an environment temperature sensor (10) for sensing temperature inside an analysis apparatus (1A), a pump (53) for drawing a liquid into pipette tip (51) and discharging liquid in the pipette tip (51), and a control unit (6a) for setting, in advance, temperature control target value during sample analysis for unit (7) based on environment temperature sensed by sensor (10), and during sample analysis, drive unit (54) lowers pipette tip (51), pump (53) performs pumping wherein intake and discharge are repeated in a state in which unit (7) blows air, and unit (6a) sets, in advance, the temperature value for use during sample analysis for the pipette tip temperature adjustment unit (7) on the basis of analysis reagent information and the environment temperature sensed by e sensor (10).

公开(公告)号：US20200269231A1

公开(公告)日：2020-08-27

申请号：US16754217

申请日：2018-10-15

Applicant: Konica Minolta, Inc.

Inventor： Youichi AOKI ,  Yuuya SHOUJI ,  Tetsuya NODA ,  Atsuo IWASHITA

IPC: B01L3/02

Abstract: Disclosed is a reaction method that includes a reaction process using a pipette tip to allow substances to cause a reaction, the method including: providing a heater for heating the pipette tip in accordance with a preset temperature; attaching the pipette tip to a pipette nozzle and heating the pipette tip by a first preset temperature; when a period of heating by the first preset temperature exceeds a preset period, switching an output of the heater from the first preset temperature to a lower second preset temperature; detecting a distal end position of the pipette tip at or after the switching; and executing the reaction process while controlling the distal end position of the pipette tip with reference to the detected distal end position, in which the temperature of the pipette tip is kept by the second preset temperature at least until operation of the pipette tip.