公开(公告)号：US20220308148A1

公开(公告)日：2022-09-29

申请号：US17617955

申请日：2020-06-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Johan Samuel Van Den Brink ,  Jochen Keupp

IPC: G01R33/561 ,  G01R33/56 ,  G01R33/563 ,  A61B5/0536 ,  A61B5/00

Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable MR signal acquisition in a single scan providing the necessary information for electric properties imaging (EPT), namely a phase map as well as tissue boundaries. The method of the invention comprises the following steps: —subjecting the object (10) to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence comprising RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; —acquiring the echo signals; —deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object (10); and —reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image. Moreover, the invention relates to a MR device for carrying out this method as well as to a computer program to be run on a MR device.

公开(公告)号：US10451692B2

公开(公告)日：2019-10-22

申请号：US14372283

申请日：2013-01-03

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christoph Leussler ,  Peter Mazurkewitz ,  Jochen Keupp

IPC: G01R33/34 ,  G01R33/36 ,  G01R33/44

Abstract: A dual- or multi-resonant RF/MR transmit and/or receive antenna (1, 2) especially in the form of a planar antenna or a volume array antenna (also called antenna array) is used for MR image generation of at least two different nuclei like e.g. 1H, 19F, 3He, 13C, 23Na or other nuclei having different Larmor frequencies. The antenna is coupled by an inductive coupling device (LI) with related transmit/receive channels (T/R). By such an inductive coupling, the tuning and matching of the antenna at the different resonant frequencies is easier than in case of a galvanic connection. The dual- or multi-resonant RF/MR transmit and/or receive antenna is used in an MR imaging apparatus.

公开(公告)号：US20150204956A1

公开(公告)日：2015-07-23

申请号：US14421861

申请日：2013-08-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Stefanie Remmele ,  Julien Senegas ,  Jochen Keupp

IPC: G01R33/50 ,  G01R33/54 ,  G01R33/385 ,  G06T15/08 ,  G01R33/56

CPC classification number: G01R33/50 ,  G01R33/385 ,  G01R33/546 ,  G01R33/56 ,  G01R33/5601 ,  G01R33/5608 ,  G06T15/08

Abstract: A magnetic resonance (MR) imaging system (600) for generating information indicative of an MR response to an oxygen breathing challenge, the MRI (600) system comprising at least one controller (610) which is configured to define a reference region (302) within a region of interest (ROI) (300 A) of reconstructed MR image information (300) including a plurality of voxels, the reference region (302) comprising a plurality of reference voxels selected from the plurality of voxels, each of the plurality of voxels having associated ΔR2* and ΔR1 values; select a cluster of voxels comprising voxels from at least the reference voxels from a multiparametric ΔR2* and ΔR1 mapping of the plurality of voxels; determine AR2* and AR\ limit points based upon at least minimum ΔR2* and ΔR1 values of voxels of the cluster of voxels; and determine outlier voxels (115) based upon a comparison of ΔR2* and ΔR1 of at least one of the plurality of voxels with respective values of the ΔR2* and ΔR1 limit points.

Abstract translation: 一种用于产生指示对氧气呼吸挑战的MR响应的信息的磁共振（MR）成像系统（600），所述MRI（600）系统包括被配置为限定参考区域（302）的至少一个控制器（610） 在包括多个体素的重建MR图像信息（300）的感兴趣区域（ROI）（300A）内，所述参考区域（302）包括从所述多个体素中选择的多个参考体素， 具有相关联的＆Dgr; R2 *和＆Dgr; R1值的体素; 从至少来自多参数的参考体素中选择包含体素的体素簇，所述多维体素的Dgr; R2 *和＆Dgr; R1映射; 基于体素簇的体素的至少最小值和Dgr; R2 *和＆Dgr; R1值;确定AR2 *和AR \限制点; 并且基于＆Dgr; R2 *和＆Dgr; R1限制点的相应值与多个体素中的至少一个的Dgr; R2 *和＆Dgr; R1的比较来确定异常体素（115）。

公开(公告)号：US12019134B2

公开(公告)日：2024-06-25

申请号：US17617955

申请日：2020-06-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Johan Samuel Van Den Brink ,  Jochen Keupp

IPC: G01R33/561 ,  A61B5/00 ,  A61B5/0536 ,  G01R33/56 ,  G01R33/563

CPC classification number: G01R33/5613 ,  A61B5/004 ,  A61B5/0536 ,  G01R33/5607 ,  G01R33/5608 ,  G01R33/5615 ,  G01R33/56341

Abstract: A method of magnet resonance (MR) imaging of an object includes MR signal acquisition in a single scan providing information for electric properties imaging (EPT), which may include a phase map as well as tissue boundaries. The method includes: subjecting the object to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence that includes RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; acquiring the echo signals; deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object; and reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image.

公开(公告)号：US20240156346A1

公开(公告)日：2024-05-16

申请号：US18282243

申请日：2022-03-11

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Jochen Keupp ,  Jan Jakob Meineke ,  Christian Stehning ,  Christophe Michael Jean Schulke ,  Mariya Invanova Doneva ,  Peter Ulrich Börnert

IPC: A61B5/00 ,  A61B5/055 ,  G16H30/00

CPC classification number: A61B5/0044 ,  A61B5/055 ,  G16H30/00

Abstract: Disclosed herein is a medical system (100, 300, 700) comprising a magnetic resonance imaging system (102) configured to acquire lines of k-space (144) data from a thoracic region (122) of a subject (118). Execution of machine executable instructions (140) causes a computational system (132) to: repeatedly (200) acquire the lines of k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands; repeatedly (202) assemble motion resolved k-space data (146) from the lines of k-space data using at least one cardiac phase and one respiratory phase of the subject as the k-space data is acquired; retrieve (204) at least a portion (148) of the motion resolved k-space data during acquisition of the k-space data; and construct (206) a preliminary three-dimensional cardiac image (150) using at least a portion of the motion resolved k-space data before acquisition of the lines of k-space data is finished. The pulse sequence commands are according to a three-dimensional free running cardiac magnetic resonance imaging protocol.

公开(公告)号：US09766313B2

公开(公告)日：2017-09-19

申请号：US14387421

申请日：2013-03-21

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Holger Eggers ,  Jochen Keupp

IPC: G01R33/48 ,  G01R33/56 ,  G01R33/24 ,  G01R33/561 ,  A61B5/055

CPC classification number: G01R33/4828 ,  A61B5/055 ,  G01R33/243 ,  G01R33/5605 ,  G01R33/5617

Abstract: The invention relates to a method of CEST or APT MR imaging of at least a portion of a body (10) placed in a main magnetic field B0 within the examination volume of a MR device. The method of the invention comprises the following steps: •a) subjecting the portion of the body (10) to a saturation RF pulse at a saturation frequency offset; •b) subjecting the portion of the body (10) to an imaging sequence comprising at least one excitation/refocusing RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body (10) as spin echo signals; •c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; •d) reconstructing a MR image and/or B0 field homogeneity corrected APT/CEST images from the acquired MR signals. Moreover, the invention relates to a MR device (1) for carrying out the method of the invention and to a computer program to be run on a MR device.

公开(公告)号：US09547061B2

公开(公告)日：2017-01-17

申请号：US14374652

申请日：2013-01-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Astrid Ruth Franz ,  Stefanie Remmele ,  Christian Stehning ,  Jochen Keupp

IPC: G06K9/00 ,  G01R33/56 ,  G06T7/00 ,  A61B5/055 ,  A61B6/00 ,  G01R33/563 ,  G06T15/08

CPC classification number: G06T7/11 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/742 ,  A61B6/037 ,  A61B6/461 ,  A61B6/481 ,  A61B6/5211 ,  G01R33/4808 ,  G01R33/5601 ,  G01R33/563 ,  G06T7/0012 ,  G06T7/174 ,  G06T7/187 ,  G06T15/08 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/20092 ,  G06T2207/20168 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: A medical imaging system (5) includes a workstation (20), a coarse segmenter (30), a fine segmenter (32), and an enclosed tissue identification module (34). The workstation (20) includes at least one input device (22) for receiving a selected location as a seed in a first contrasted tissue type and a display device (26) which displays a diagnostic image delineating a first segmented region of a first tissue type and a second segmented region of a second contrasted tissue type and identified regions which include regions fully enclosed by the first segmented region as a third tissue type. The coarse segmenter (30) grows a coarse segmented region of coarse voxels for each contrasted tissue type from the seed location based on a first growing algorithm and a growing fraction for each contrasted tissue type. The seed location for growing the second contrasted tissue type includes the first coarse segmented region and any fully enclosed coarse voxels, and each coarse voxel includes an aggregation of voxels and a maximum and a minimum of the voxel intensities. The fine segmenter (32) grows a segmented region of voxels for each contrasted tissue type from the seed location and bounded by the second coarse segmented region based on a second growing algorithm and a growing fraction for each contrasted tissue type initially set to the growing fraction for the corresponding region. The seed location for growing the second contrasted tissue type includes the first segmented region and any identified regions. The enclosed tissue identification module (34) identifies any regions of voxels fully enclosed by the first segmented region as being of the third tissue type. The coarse segmenter, the fine segmenter, and the enclosed tissue identification module are implemented by an electronic data processing device.

Abstract translation: 医疗成像系统（5）包括工作站（20），粗分割器（30），精细分割器（32）和封闭的组织识别模块（34）。 工作站（20）包括至少一个输入装置（22），用于以第一对比组织类型的种子的形式接收所选择的位置，以及显示装置（26），其显示描绘第一组织类型的第一分割区域 以及第二对比组织类型的第二分割区域和被识别的区域，其包括由第一分割区域完全包围的区域作为第三组织类型。 粗分割器（30）基于第一生长算法和每个对比组织类型的生长部分，从种子位置为每个对比组织类型生长粗体素的粗分割区域。 用于生长第二对比组织类型的种子位置包括第一粗分段区域和任何完全封闭的粗体素，并且每个粗体素包括体素的聚集和体素强度的最大和最小值。 细分割器（32）基于第二种生长算法，从种子位置生长每个对比组织类型的分形区域，并由第二粗分段区域生长，并且对于初始设置为生长部分的每个对比组织类型的生长部分 对于相应的区域。 用于生长第二对比组织类型的种子位置包括第一分割区域和任何识别的区域。 封闭的组织识别模块（34）将由第一分段区域完全包围的体素的任何区域识别为第三组织类型。 粗分割器，精细分割器和封闭组织识别模块由电子数据处理装置实现。

公开(公告)号：US20250138117A1

公开(公告)日：2025-05-01

申请号：US18690775

申请日：2022-09-07

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Bernhard Gleich ,  George Randall Duensing ,  Johannes Adrianus Overweg ,  Peter Ulrich Börnert ,  Jochen Keupp

IPC: G01R33/385 ,  G01R33/3815 ,  G01R33/383

Abstract: Disclosed herein is a mechanical gradient magnetic field generator (100, 500, 1600, 1700, 2000, 2112) comprising a field generating element (102) comprising at least one generator layer (104). Each of the at least one generator layer comprises: a stationary divider (106); a movable divider (108) configured for moving in one (110) or two (1602) displacement directions; a mechanical element (112) configured to mechanically assist movement of the movable divider in the one or two displacement directions towards an initial position (508); and a set of rotatable magnets (114) positioned between the movable divider and the stationary divider. The set of rotatable magnets are mechanically coupled to the movable divider and to the stationary divider. The mechanical coupling of the set of rotatable magnets is such that movement of the movable divider in the one or two displacement directions causes an individual rotation of each of the set of rotatable magnets.

公开(公告)号：US20230028306A1

公开(公告)日：2023-01-26

申请号：US17777713

申请日：2020-11-17

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Pieter Jan van der Zaag ,  Wilhelmus Franciscus Johannes Verhaegh ,  Jochen Keupp

IPC: G06T7/00

Abstract: The present invention relates to an apparatus (10) for diagnostic image acquisition, comprising: an input unit (20); a processing unit (30); and an output unit (40). The input unit is configured to receive a data value relating to at least one biomarker in a measurement blood sample of a patient. The processing unit is configured to determine a time to acquire a diagnostic image of the patient, wherein the determination comprises utilization of the data value. The output unit is configured to output an indication of the time to acquire the diagnostic image of the patient.

公开(公告)号：US10935617B2

公开(公告)日：2021-03-02

申请号：US16463922

申请日：2017-11-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Jochen Keupp ,  Jan Jakob Meineke ,  Karsten Sommer

IPC: G01V3/00 ,  G01R33/54 ,  G01R33/50 ,  G01R33/56 ,  G01R33/58

Abstract: The invention provides for a magnetic resonance imaging system (100) comprising a memory (134) for storing machine executable instructions (140) and pulse sequence commands (142). The pulse sequence commands are configured for controlling the magnetic resonance imaging system according to a DCE Magnetic Resonance Imaging protocol. The magnetic resonance imaging system further comprises a user interface (200) and a processor (130) for controlling the magnetic resonance imaging system. Execution of the machine executable instructions causes the processor to: control (500) the magnetic resonance imaging system using the pulse sequence commands to acquire calibration magnetic resonance data (144) two or more times for varying flip angles; reconstruct (502) each acquisition of the calibration magnetic resonance data into a calibration image (146) to create a set of variable flip angle images (148); calculate (504) a T1 mapping (150) using the set of variable flip angle images; calculate (506) a contrast agent calibration (152) for a predetermined magnetic resonance imaging contrast agent using at least partially the T1 mapping; calculate (508) an estimated calibration error (154) that is descriptive of an estimated error in the contrast agent calibration and/or the T1 mapping using a calibration accuracy model, wherein the calibration accuracy model is configured for calculating the estimated calibration error using the set of variable flip angle images; and display (510) a calibration warning message (202) on the user interface if the estimated calibration error is outside of a predetermined calibration error range.