公开(公告)号：US09757402B2

公开(公告)日：2017-09-12

申请号：US14855645

申请日：2015-09-16

申请人： KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP

发明人： Seung-Jae Lee ,  He-Jin Lee ,  Eun-Jin Bae ,  Dong Kyu Kim

IPC分类号： C12N15/00 ,  G01N33/52 ,  A61K31/7008 ,  A01K67/033 ,  A61K49/00 ,  A61K31/00 ,  G01N33/50

CPC分类号： A61K31/7008 ,  A01K67/0336 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/703 ,  A01K2267/0318 ,  A01K2267/0393 ,  A61K31/00 ,  A61K49/0008 ,  A61K49/0045 ,  G01N33/5058 ,  G01N2500/10 ,  G01N2800/28

摘要： The present disclosure relates to dual-cell model and Caenorhabditis elegans model systems for measuring neuron-to-neuron transmission of protein aggregates, and more particularly to transgenic cell and animal model systems expressing fusion proteins of N-terminus or C-terminus of fluorescent proteins with α-synuclein proteins, methods for measuring continuous cell-to-cell transmission of α-synuclein aggregates using the same, and methods for screening substances for preventing or treating neurodegenerative diseases.