公开(公告)号：US11497821B2

公开(公告)日：2022-11-15

申请号：US16897894

申请日：2020-06-10

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi

IPC: A61K51/08 ,  A61K47/54 ,  C07C13/45

Abstract: The present disclosure relates to a method for labeling a biomolecule, a fluorescent dye, or a nanoparticle compound with a radioisotope, comprising: (a) providing a cyclooctyne compound represented by the following formula (I) comprising the biomolecule, the fluorescent dye, or the nanoparticle compound which is bound to a cyclooctyne moiety of the cyclooctyne compound; and (b) reacting the cyclooctyne compound of formula (I) with a quinone compound represented by the following formula (II) to give a biomolecule, a fluorescent dye, or a nanoparticle compound labeled with the radioisotope: in formula (I), (Z is the biomolecule, the fluorescent dye, or the nanoparticle compound) in formula (II), (b is 0 or an integer from 1 to 10; L is CH2, —COO—, or —CONH—; M is the radioisotope).

公开(公告)号：US10435309B2

公开(公告)日：2019-10-08

申请号：US15493459

申请日：2017-04-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Jong Ho Jeon ,  Mi Hee Choi ,  Ha Eun Sim ,  Seong Jae Yun ,  Sang Hyun Park ,  Beom Su Jang ,  Dae Seong Choi ,  Dong Eun Lee ,  Eui Baek Byun

IPC: C02F1/28 ,  B01D15/08 ,  B01J20/02 ,  B01J20/28 ,  B01J20/24 ,  B01J20/281 ,  C02F101/12 ,  C02F101/00 ,  C02F103/00

Abstract: A process for removing iodine using gold particles includes contacting a solution including iodine, with gold particles. The iodine is adsorbed onto the gold particles and then removed. A device for removing iodine using gold particles includes gold particles in a stationary phase and is configured to contact a solution including iodine, with gold particles, to thus adsorb the iodine onto the gold particles and remove the iodine.

公开(公告)号：US20170305760A1

公开(公告)日：2017-10-26

申请号：US15493459

申请日：2017-04-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Jong Ho Jeon ,  Mi Hee Choi ,  Ha Eun Sim ,  Seong Jae Yun ,  Sang Hyun Park ,  Beom Su Jang ,  Dae Seong Choi ,  Dong Eun Lee ,  Eui Baek Byun

IPC: C02F1/28 ,  B01J20/02 ,  B01J20/281 ,  B01D15/08 ,  B01J20/28 ,  B01J20/24 ,  C02F101/12

CPC classification number: C02F1/281 ,  B01D15/08 ,  B01J20/02 ,  B01J20/24 ,  B01J20/28004 ,  B01J20/28007 ,  B01J20/28016 ,  B01J20/28033 ,  B01J20/281 ,  B01J2220/52 ,  C02F2101/006 ,  C02F2101/12 ,  C02F2103/003

Abstract: A process for removing iodine using gold particles includes contacting a solution including iodine, with gold particles. The iodine is adsorbed onto the gold particles and then removed. A device for removing iodine using gold particles includes gold particles in a stationary phase and is configured to contact a solution including iodine, with gold particles, to thus adsorb the iodine onto the gold particles and remove the iodine.

公开(公告)号：US11298431B2

公开(公告)日：2022-04-12

申请号：US16512517

申请日：2019-07-16

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi ,  Beom Su Jang ,  Eui-Baek Byun ,  Jongho Jeon ,  Dong-Eun Lee

IPC: A61K51/04 ,  G01N33/533 ,  A61K51/02 ,  G01N33/534 ,  A61K51/08 ,  A61K51/12 ,  A61K51/10

Abstract: The present disclosure relates to a method for labeling a radioisotope, a radiolabeling compound, a kit including the same, and a method for labeling a radioisotope, including: providing a diaminophenyl compound represented by Chemical Formula I below and including a biomolecule, a fluorescent dye or a nanoparticle compound bound thereto; and reacting the diaminophenyl compound and a radioisotope-labeled aldehyde compound represented by Chemical Formula II below at room temperature; and a related technology: in Chemical Formula I, A is CH2 or O; a is 0 or an integer of 1 to 10; X is CH2 or —CONH—; Y is CH2 or  and Z is the biomolecule, the fluorescent dye or the nanoparticle compound, in Chemical Formula II, b is 0 or an integer of 1 to 10; and L is CH2 or —CONH—; and Q is M, M′ and M″ in Q are radioisotopes.

公开(公告)号：US20200023085A1

公开(公告)日：2020-01-23

申请号：US16512517

申请日：2019-07-16

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi ,  Beom Su Jang ,  Eui-Baek Byun ,  Jongho Jeon ,  Dong-Eun Lee

IPC: A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  A61K51/02 ,  A61K51/12 ,  G01N33/534 ,  G01N33/533

Abstract: The present disclosure relates to a method for labeling a radioisotope, a radiolabeling compound, a kit including the same, and a method for labeling a radioisotope, including: providing a diaminophenyl compound represented by Chemical Formula I below and including a biomolecule, a fluorescent dye or a nanoparticle compound bound thereto; and reacting the diaminophenyl compound and a radioisotope-labeled aldehyde compound represented by Chemical Formula II below at room temperature; and a related technology: in Chemical Formula I, A is CH2 or O; a is 0 or an integer of 1 to 10; X is CH2 or —CONH—; Y is CH2 or and Z is the biomolecule, the fluorescent dye or the nanoparticle compound, in Chemical Formula II, b is 0 or an integer of 1 to 10; and L is CH2 or —CONH—; and Q is or M, M′ and M″ in Q are radioisotopes.