公开(公告)号：US20170305760A1

公开(公告)日：2017-10-26

申请号：US15493459

申请日：2017-04-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Jong Ho Jeon ,  Mi Hee Choi ,  Ha Eun Sim ,  Seong Jae Yun ,  Sang Hyun Park ,  Beom Su Jang ,  Dae Seong Choi ,  Dong Eun Lee ,  Eui Baek Byun

IPC: C02F1/28 ,  B01J20/02 ,  B01J20/281 ,  B01D15/08 ,  B01J20/28 ,  B01J20/24 ,  C02F101/12

CPC classification number: C02F1/281 ,  B01D15/08 ,  B01J20/02 ,  B01J20/24 ,  B01J20/28004 ,  B01J20/28007 ,  B01J20/28016 ,  B01J20/28033 ,  B01J20/281 ,  B01J2220/52 ,  C02F2101/006 ,  C02F2101/12 ,  C02F2103/003

Abstract: A process for removing iodine using gold particles includes contacting a solution including iodine, with gold particles. The iodine is adsorbed onto the gold particles and then removed. A device for removing iodine using gold particles includes gold particles in a stationary phase and is configured to contact a solution including iodine, with gold particles, to thus adsorb the iodine onto the gold particles and remove the iodine.

公开(公告)号：US20220265902A1

公开(公告)日：2022-08-25

申请号：US17680486

申请日：2022-02-25

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Muhammad Asim Raza

IPC: A61L27/52 ,  C08L5/08 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

Abstract: The present disclosure provides a hydrogel that has excellent drug delivery ability, is pH-dependent, is biocompatible, and has its own anticancer efficacy as well as biodegradability, and a method for preparing the same. Specifically, the present disclosure provides a hydrogel including carboxymethyl-chitosan (CM-CS) and a hydrophilic synthetic polymer wherein the hydrogel is crosslinked by electron beam irradiation, and a method for preparing the same.

公开(公告)号：US10435309B2

公开(公告)日：2019-10-08

申请号：US15493459

申请日：2017-04-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Jong Ho Jeon ,  Mi Hee Choi ,  Ha Eun Sim ,  Seong Jae Yun ,  Sang Hyun Park ,  Beom Su Jang ,  Dae Seong Choi ,  Dong Eun Lee ,  Eui Baek Byun

IPC: C02F1/28 ,  B01D15/08 ,  B01J20/02 ,  B01J20/28 ,  B01J20/24 ,  B01J20/281 ,  C02F101/12 ,  C02F101/00 ,  C02F103/00

Abstract: A process for removing iodine using gold particles includes contacting a solution including iodine, with gold particles. The iodine is adsorbed onto the gold particles and then removed. A device for removing iodine using gold particles includes gold particles in a stationary phase and is configured to contact a solution including iodine, with gold particles, to thus adsorb the iodine onto the gold particles and remove the iodine.

公开(公告)号：US09610306B2

公开(公告)日：2017-04-04

申请号：US15076352

申请日：2016-03-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Beom Su Jang ,  YouRee Nam

IPC: A61K35/64

CPC classification number: A61K35/64 ,  A61K35/63

Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of tissue injury caused by irradiation which comprises silkworm hemolymph as an active ingredient. Particularly, when the silkworm hemolymph of the present invention was administered to an animal model with liver damage induced by irradiation, plasma AST and liver MDA were significantly decreased, indicating that the silkworm hemolymph of the invention can be effectively used as a composition for the prevention and treatment of disease caused by the exposure on radiation including tissue injury caused by irradiation, etc.

公开(公告)号：US20160199420A1

公开(公告)日：2016-07-14

申请号：US15076352

申请日：2016-03-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Beom Su Jang ,  YouRee Nam

IPC: A61K35/64

CPC classification number: A61K35/64 ,  A61K35/63

Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of tissue injury caused by irradiation which comprises silkworm hemolymph as an active ingredient. Particularly, when the silkworm hemolymph of the present invention was administered to an animal model with liver damage induced by irradiation, plasma AST and liver MDA were significantly decreased, indicating that the silkworm hemolymph of the invention can be effectively used as a composition for the prevention and treatment of disease caused by the exposure on radiation including tissue injury caused by irradiation, etc.

Abstract translation: 本发明涉及一种用于预防和治疗由辐射引起的组织损伤的药物组合物，其包含蚕血淋淋作为活性成分。 特别地，当将本发明的蚕血淋巴给予具有由照射引起的肝损伤的动物模型时，血浆AST和肝脏MDA显着降低，表明本发明的蚕血淋淋可有效地用作预防组合物 以及由辐射引起的疾病引起的疾病的治疗，包括照射引起的组织损伤等。

公开(公告)号：US20150151011A1

公开(公告)日：2015-06-04

申请号：US14399431

申请日：2013-05-13

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Beom Su Jang ,  Sang Hyun Park ,  Joo-Sang Lee ,  Jong-Kook Rho

IPC: A61K51/08 ,  C07K7/06 ,  C07K1/13 ,  C07K5/083 ,  C07B59/00 ,  C07C227/16

CPC classification number: A61K51/082 ,  A61K51/025 ,  A61K51/0406 ,  A61K51/085 ,  A61K51/088 ,  C07B59/001 ,  C07B2200/05 ,  C07C227/16 ,  C07K1/13 ,  C07K5/0806 ,  C07K7/06

Abstract: Disclosed is a technetium-99m-labeled glycine oligomer associated with imaging probes for biomolecules of interest. The glycine oligomer can be readily synthesized in a single process using an automated peptide synthesizer. The technetium-99m tricarbonyl-labeled glycine oligomers can be useful as a radiotracer for gamma or SPECT imaging apparatus. The technetium-99m tricarbonyl-labeled glycine oligomers can be applied to various peptidyl biomolecules such as RGD peptide, somatostatin, neurotensin, etc., and exhibit rapid renal clearance without being excessively retained within the body.

Abstract translation: 公开了与感兴趣的生物分子的成像探针相关的锝-99m标记的甘氨酸低聚物。 甘氨酸低聚物可以使用自动化肽合成仪在单一过程中容易地合成。 锝-99m三羰基标记的甘氨酸低聚物可用作γ或SPECT成像装置的放射性示踪剂。 锝-99m三羰基标记的甘氨酸低聚物可以应用于各种肽基生物分子如RGD肽，生长抑素，神经降压素等，并且表现出快速的肾清除，而不会被过度保留在体内。

公开(公告)号：US11497821B2

公开(公告)日：2022-11-15

申请号：US16897894

申请日：2020-06-10

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi

IPC: A61K51/08 ,  A61K47/54 ,  C07C13/45

Abstract: The present disclosure relates to a method for labeling a biomolecule, a fluorescent dye, or a nanoparticle compound with a radioisotope, comprising: (a) providing a cyclooctyne compound represented by the following formula (I) comprising the biomolecule, the fluorescent dye, or the nanoparticle compound which is bound to a cyclooctyne moiety of the cyclooctyne compound; and (b) reacting the cyclooctyne compound of formula (I) with a quinone compound represented by the following formula (II) to give a biomolecule, a fluorescent dye, or a nanoparticle compound labeled with the radioisotope: in formula (I), (Z is the biomolecule, the fluorescent dye, or the nanoparticle compound) in formula (II), (b is 0 or an integer from 1 to 10; L is CH2, —COO—, or —CONH—; M is the radioisotope).

公开(公告)号：US11298431B2

公开(公告)日：2022-04-12

申请号：US16512517

申请日：2019-07-16

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi ,  Beom Su Jang ,  Eui-Baek Byun ,  Jongho Jeon ,  Dong-Eun Lee

IPC: A61K51/04 ,  G01N33/533 ,  A61K51/02 ,  G01N33/534 ,  A61K51/08 ,  A61K51/12 ,  A61K51/10

Abstract: The present disclosure relates to a method for labeling a radioisotope, a radiolabeling compound, a kit including the same, and a method for labeling a radioisotope, including: providing a diaminophenyl compound represented by Chemical Formula I below and including a biomolecule, a fluorescent dye or a nanoparticle compound bound thereto; and reacting the diaminophenyl compound and a radioisotope-labeled aldehyde compound represented by Chemical Formula II below at room temperature; and a related technology: in Chemical Formula I, A is CH2 or O; a is 0 or an integer of 1 to 10; X is CH2 or —CONH—; Y is CH2 or  and Z is the biomolecule, the fluorescent dye or the nanoparticle compound, in Chemical Formula II, b is 0 or an integer of 1 to 10; and L is CH2 or —CONH—; and Q is M, M′ and M″ in Q are radioisotopes.

公开(公告)号：US20200023085A1

公开(公告)日：2020-01-23

申请号：US16512517

申请日：2019-07-16

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang Hyun Park ,  Sajid Mushtaq ,  Dae Seong Choi ,  Beom Su Jang ,  Eui-Baek Byun ,  Jongho Jeon ,  Dong-Eun Lee

IPC: A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  A61K51/02 ,  A61K51/12 ,  G01N33/534 ,  G01N33/533

Abstract: The present disclosure relates to a method for labeling a radioisotope, a radiolabeling compound, a kit including the same, and a method for labeling a radioisotope, including: providing a diaminophenyl compound represented by Chemical Formula I below and including a biomolecule, a fluorescent dye or a nanoparticle compound bound thereto; and reacting the diaminophenyl compound and a radioisotope-labeled aldehyde compound represented by Chemical Formula II below at room temperature; and a related technology: in Chemical Formula I, A is CH2 or O; a is 0 or an integer of 1 to 10; X is CH2 or —CONH—; Y is CH2 or and Z is the biomolecule, the fluorescent dye or the nanoparticle compound, in Chemical Formula II, b is 0 or an integer of 1 to 10; and L is CH2 or —CONH—; and Q is or M, M′ and M″ in Q are radioisotopes.

公开(公告)号：US20140314668A1

公开(公告)日：2014-10-23

申请号：US14175940

申请日：2014-02-07

Applicant: Korea Atomic Energy Research Institute

Inventor： Beom Su Jang ,  Sang Hyun Park ,  Joo-Sang Lee ,  Jong-Kook Rho

IPC: A61K51/08

CPC classification number: A61K51/1251

Abstract: There is provided a method for preparing a 99mTc labeled gold nanoparticles-gold binding peptide, including: (a) coating gold nanoparticles with a gold binding peptide; and (b) labeling a composed 99mTc tricarbonyl precursor on the gold binding peptide coated on the gold nanoparticles. The 99mTc labeled gold nanoparticles-gold binding peptide prepared by the method according to the present invention is expected to be usefully employed for manufacturing a molecular contrast agent (imaging agent) which is traceable in organisms using imaging apparatuses such as gamma imaging and single photon emission computed tomography due to high labeling yield and good in-vivo stability.

Abstract translation: 提供了一种制备99mTc标记的金纳米粒子 - 金结合肽的方法，包括：（a）用金结合肽涂覆金纳米颗粒; 和（b）在包被在金纳米颗粒上的金结合肽上标记组成的99mTc三羰基前体。 预期通过根据本发明的方法制备的99mTc标记的金纳米粒子 - 金结合肽可用于制造在生物体中可追踪的分子造影剂（成像剂），其使用诸如γ成像和单光子发射的成像装置 计算机断层扫描由于高的标记产率和良好的体内稳定性。