公开(公告)号：US20180112183A1

公开(公告)日：2018-04-26

申请号：US15551595

申请日：2016-05-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Heon KIM ,  Kwi Deok PARK ,  Kang Won LEE ,  Thanavel RAJANGAM

IPC: C12N5/0775 ,  G01N33/50

CPC classification number: C12N5/0662 ,  C12N5/0667 ,  C12N2320/10 ,  C12N2506/13 ,  C12N2513/00 ,  C12N2533/30 ,  G01N33/50 ,  G01N33/5008 ,  G01N33/5073

Abstract: Provided are an in vitro fibrosis model, a method of preparing the in vitro model, and use of the in vitro model, the in vitro model including a cell cluster differentiated from mesenchymal cells, wherein the cell cluster exhibits pathological characteristics of fibrosis.

公开(公告)号：US20180252715A1

公开(公告)日：2018-09-06

申请号：US15560482

申请日：2016-04-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Heon KIM ,  Jong Hoon CHOI ,  Kwi Deok PARK

IPC: G01N33/574 ,  C07K14/78 ,  C12N9/64

Abstract: Provided are a three-dimensional (3D) fibroblast cluster, a method of preparing the same, an in vitro 3D skin dermis model including a fibroblast cluster cultured from a fibroblast, and a method of screening a drug by using the in vitro 3D skin dermis model.

公开(公告)号：US20160339149A1

公开(公告)日：2016-11-24

申请号：US15156068

申请日：2016-05-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwi Deok PARK ,  In Gul KIM ,  Sang Heon KIM ,  Kang Won LEE ,  Min Tai Peter HWANG

IPC: A61L27/40 ,  A61L27/16 ,  A61L27/36

CPC classification number: A61L27/3687 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/20 ,  C08L89/00 ,  C08L29/04

Abstract: Provided are a method of producing a cross-linked PVA-ECM composite, and a PVA-ECM composite produced by using the method.

Abstract translation: 提供一种生产交联PVA-ECM复合材料的方法和使用该方法制备的PVA-ECM复合材料。

公开(公告)号：US20210015974A1

公开(公告)日：2021-01-21

申请号：US16919111

申请日：2020-07-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwi Deok PARK ,  Jong Ho LEE ,  Eui Sun SONG ,  Yoon Ki JOUNG

IPC: A61L27/36 ,  A61L27/58 ,  A61L27/18 ,  A61L27/54

Abstract: Provided are a biodegradable polymeric film including an extracellular matrix, and use thereof, and particularly, a method of producing a poly(lactide-co-ε-caprolactone) film including an extracellular matrix, a film produced by the method, and an ophthalmic material including the film.

公开(公告)号：US20200071674A1

公开(公告)日：2020-03-05

申请号：US16678014

申请日：2019-11-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Heon KIM ,  Kwi Deok PARK ,  Kang Won LEE ,  Thanavel RAJANGAM

IPC: C12N5/0775 ,  G01N33/50

Abstract: Provided are an in vitro fibrosis model, a method of preparing the in vitro model, and use of the in vitro model, the in vitro model including a cell cluster differentiated from mesenchymal cells, wherein the cell cluster exhibits pathological characteristics of fibrosis.

公开(公告)号：US20170049823A1

公开(公告)日：2017-02-23

申请号：US15165292

申请日：2016-05-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Heon KIM ,  Kwi Deok PARK ,  Kang Won LEE ,  Jung Mi KANG

IPC: A61K35/34 ,  A61K35/35 ,  A61K9/00 ,  A61K38/18

CPC classification number: A61K35/34 ,  A61K9/0024 ,  A61K35/28 ,  A61K38/1891 ,  A61L27/227 ,  A61L27/3834 ,  A61K2300/00

Abstract: Provided is a pharmaceutical composition for preventing and treating ischemic disease, the composition including a cell cluster or a culture thereof; and an angiopoietin. The pharmaceutical composition is used to synergistically treat ischemic disease, compared to single administration of the effective ingredients, and the composition does not induce fibrosis in the administered area.

Abstract translation: 提供了用于预防和治疗缺血性疾病的药物组合物，所述组合物包含细胞簇或其培养物; 和血管生成素。 与单次施用有效成分相比，药物组合物用于协同治疗缺血性疾病，并且组合物在给药区域中不诱导纤维化。