公开(公告)号：US20190247850A1

公开(公告)日：2019-08-15

申请号：US16225472

申请日：2018-12-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sangyoup LEE ,  Junho Choi ,  Sehoon Kim ,  Daewoong Lee ,  Seunghan Park ,  Cherlhyun Jeong

IPC: B01L3/00

CPC classification number: B01L3/50851 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/1805

Abstract: In a compact multi molecular diagnosis system and a multi molecular diagnosis apparatus, the multi molecular diagnosis system includes a card part, a pretreatment and collector, a cleaner, a reagent unit, a heater and an optical unit. The card part moves in a rotating frame, and has a plurality of cards. The pretreatment and collector provides a collected specimen to each card of the card part. The cleaner provides a cleaning liquid to the card part, to clean the collected specimen in the card part. The reagent unit provides a plurality of diagnosis reagents to each card of the card part. The heater heats the card part absorbing the reagent, to clone a virus template. The optical unit observes the cloned virus template. The card part sequentially moves through the pretreatment and collector, the cleaner, the reagent unit, the heater and the optical unit.

公开(公告)号：US20150273084A1

公开(公告)日：2015-10-01

申请号：US14667935

申请日：2015-03-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon KIM ,  Ick Chan KWON ,  Sangyoup LEE

IPC: A61K49/00 ,  A61K9/00 ,  A61K9/107 ,  A61K41/00

CPC classification number: A61K41/0057 ,  A61K9/1075 ,  A61K9/5123 ,  A61K9/5146 ,  A61K49/003 ,  A61K49/0082

Abstract: The present invention relates to a methylene blue nanoparticle for bioimaging and photodynamic therapy, and a use thereof as a cancer therapeutic agent and a contrast agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting photo therapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating singlet oxygen and the like, and thus may be used for both bioimaging diagnosis such as optical imaging, and cancer targeting photodynamic therapy.

Abstract translation: 本发明涉及用于生物成像和光动力学治疗的亚甲基蓝纳米颗粒及其作为癌症治疗剂和造影剂的用途。 用作局部癌症靶向光疗法的本发明的亚甲基蓝纳米颗粒仅由组合物临床使用或衍生自人体的材料组成，因此其中临床进入的障碍低的纳米制备 并且商品化的可能性非常高，显示近红外荧光以及癌靶向性，产生单线态氧的能力等，因此可用于生物成像诊断例如光学成像和癌症靶向光动力疗法。