公开(公告)号：US09724334B1

公开(公告)日：2017-08-08

申请号：US15417315

申请日：2017-01-27

申请人： Kyungpook National University Industry-Academic Cooperation Foundation

发明人： Jae-Sung Bae ,  Hee Kyung Jin ,  Min Hee Park

IPC分类号： A61K31/4192 ,  C07D249/04

CPC分类号： A61K31/4192 ,  C07D249/04

摘要： A method for treating a neurodegenerative disease and depression, the method comprising administering to a subject in need thereof an effective amount of a composition comprising derivatives of 2-amino-2-(1-dodecyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol as an active ingredient.

公开(公告)号：US11899025B2

公开(公告)日：2024-02-13

申请号：US16982494

申请日：2019-03-21

申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Jae-Sung Bae ,  Hee Kyung Jin ,  Ju Youn Lee ,  Seung Hoon Han

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N33/573 ,  A61K31/164

CPC分类号： G01N33/6896 ,  A61K31/164 ,  G01N33/5008 ,  G01N33/573 ,  G01N2333/90241 ,  G01N2440/10

摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-β in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-β in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.

公开(公告)号：US11466305B2

公开(公告)日：2022-10-11

申请号：US16462899

申请日：2017-10-20

申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) ,  SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

发明人： Jae-Sung Bae ,  Hee Kyung Jin ,  Ju Youn Lee ,  Seung Hyun Kim ,  Chang-Seok Ki

IPC分类号： C12Q1/44 ,  G01N33/92

摘要： The present invention relates to a amyotrophic lateral sclerosis (ALS) diagnostic composition using acid sphingomyelinase (ASM), and a method for detecting diagnostic markers and, more specifically, to a method and a composition for detecting markers for ALS, the method comprising the steps of: (a) providing a sample of a subject; (b) measuring the ASM expression level or the enzyme activation level in the sample; (c) determining that a subject, of which the ASM expression level or the enzyme activation level is increased compared to that of a normal person, has ALS. According to the investigation of the present inventors, the activity of ASM, among lipids and enzymes related to the sphingolipid metabolism, is specifically increased in a sample of an ALS patient compared to that of a normal person. ASM can be used as a marker for diagnosing ALS, thereby enabling the development of a novel and effective diagnostic reagent.